21
Glen A Carey, Michael L Malek: Incubation chamber. Chiron Diagnostics Corporation, Arthur S Morgenstern, Charles L Gagnebin III, Robert P Blackburn, October 27, 1998: US05827478 (64 worldwide citation)

Method and apparatus for transportation and processing of multiple protocol assays within an automated immunoassay analyzer instrument. The apparatus includes a cuvette ring movably coupled to a magnet ring. In one embodiment, the magnet ring and cuvette ring are provided having circular shapes. A t ...


22
Michael L Malek, Glen A Carey, Gregory A Coghlan: Luminometer. Chiron Diagnostics Corporation, Arthur S Morgenstern, Charles L Gagnebin III, Robert P Blackburn, November 17, 1998: US05837195 (57 worldwide citation)

A luminometer for determining the composition of a specimen sample includes an annular guide path for sample containing cuvettes within a light tight housing. A rotor moves spaced segments through the guide path with the cuvettes positioned between the segments. The luminometer further includes one ...


23
Richard A Martinelli, Jeffrey J Donahue, John T Unger: Amplification of midivariant DNA templates. Ciba Corning Diagnostics, Nicholas I Slepchuk Jr, Arthur S Morgenstern, Judith A Roesler, April 18, 1995: US05407798 (56 worldwide citation)

New methods are provided for the amplification of a midivariant DNA containing an inserted target specific nucleic acid sequence(s) to enable detection of the presence of a target nucleic acid sequence in a test sample. One method employs midivariant DNA as a template for the synthesis of RNA cataly ...


24
Say Jong Law: Nucleophilic polysubstituted aryl acridinium esters and uses thereof. Ciba Corning Diagnostics, Arthur S Morgenstern, Nicholas I Slepchuk Jr, August 31, 1993: US05241070 (54 worldwide citation)

This invention is directed to novel nucleophilic polysubstituted aryl acridinium esters and to novel conjugates thereof. The novel nucleophilic polysubstituted aryl acridinium esters and novel conjugates thereof are useful in biological assays, including novel assays for the determination of Vitamin ...


25
Richard A Dussault: Electrical connection system for electrochemical sensors. Ciba Corning Diagnostics, Arthur S Morgenstern, Nicholas I Slepchuk Jr, Judith A Roesler, June 6, 1995: US05421189 (53 worldwide citation)

An electrochemical/gas analyzer providing a rugged contact system for removable sensors capable of withstanding inexpert sensor insertion or removal, providing protection for high impedance input electronics against electrostatic discharge (ESD) damage, and providing automatic connection to diagnost ...


26
Richard A Martinelli, John C Arruda: Hybridization-ligation assays for the detection of specific nucleic acid sequences. Chiron Diagnostics Corporation, Arthur S Morgenstern, Robert P Blackburn, September 1, 1998: US05800994 (53 worldwide citation)

A new method has been developed for conducting a gene probe assay. The preferred technique involves (1) using a gene amplification technique (e.g., PCR) to multiply the gene sequence of interest and (2) using a hybridization--ligation detection methodology, wherein the sequences of probes hybridized ...


27
Lester Sodickson, Ronald S Scharlack: Apparatus and methods for the analytical determination of sample component concentrations that account for experimental error. Chiron Diagnostics Corporation, Arthur S Morgenstern, Gordon Moriarty, Robert P Blackburn, March 3, 1998: US05724268 (51 worldwide citation)

The present invention provides apparatus and methods for determining the concentration of sample components of a sample by an analytical technique that yields a spectrum that can be written as Y(.omega.)=P(.omega.).multidot.C. The apparatus and methods of the invention account for experimental error ...


28
Rudolf E Slovacek, Walter F Love, Thomas A Cook, Richard L Schulkind, Irene M Walczak: Multiple surface evanescent wave sensor with a reference. Ciba Corning Diagnostics, Nicholas I Slepchuk Jr, Arthur S Morgenstern, Judith A Roesler, August 23, 1994: US05340715 (50 worldwide citation)

An evanescent wave sensor and method for use in analyzing one or more media, the sensor including a waveguide having first and second wave propagating surfaces. The waveguide propagates an input signal along the waveguide between the first and second surfaces. The first surface receives a first radi ...


29
Glen A Carey, Scott C Lewis, Mary Beth Whitesel, Frank C Klingshirn: Automated analyzer having magnetic isolation device and method using the same. Chiron Diagnostics Corporation, Arthur S Morgenstern, Gordon R Moriarty, Robert P Blackburn, April 21, 1998: US05741708 (48 worldwide citation)

An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reagent containers, sample and reagent ...


30
Victoria E DeMoranville, James E Ellis: Clinical laboratory work-flow system which semi-automates validated immunoassay and electrophoresis protocols. Nicholas I Slepchuk, Arthur S Morgenstern, October 11, 1994: US05355304 (47 worldwide citation)

A multi-tasking clinical laboratory work-flow system for test sample and reagent transfer to semi-automate various laboratory assays. The system includes a controller having a menu of protocols which provide format instructions to a robotic sample transfer device. The sample transfer device includes ...