1
Wesley Bryan Dong: Methods and apparatus for minimizing evaporation of sample materials from multiwell plates. Caliper Life Sciences, Ann C Peterson, Donald R McKenna, April 24, 2007: US07208125 (55 worldwide citation)

Methods and devices for reducing evaporation of sample materials from the wells of multiwell plates are disclosed which find particular utility when the plates are placed in a stacked configuration. An example of the methods includes providing at least a first multiwell plate which is configured to ...


2
Calvin Y H Chow, J Wallace Parce: Devices, systems and methods for time domain multiplexing of reagents. Caliper Technologies, Ann C Peterson, Donald R McKenna, October 2, 2007: US07276330 (54 worldwide citation)

Time dependent iterative reactions are carried out in microscale fluidic channels by configuring the channels such that reagents from different sources are delivered to a central reaction zone at different times during the analysis, allowing for the performance of a variety of time dependent, and/or ...


3
Anubhav Tripathi, Josh Molho: Method for measuring diffusivities of compounds using microchips. Caliper Life Sciences, Donald R McKenna, Ann C Peterson, May 2, 2006: US07039527 (45 worldwide citation)

A method for determining the molecular diffusivity of a solute in a microchannel where a solute is introduced into a first end of a microchannel and a first concentration profile is measured at first and second locations along the microchannel. A theoretical concentration profile can be calculated a ...


4
Ring Ling Chien: Method for determining diffusivity and molecular weight in a microfluidic device. Caliper Life Sciences, Donald R McKenna, Ann C Peterson, June 19, 2007: US07233865 (6 worldwide citation)

The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a sample stream comprising a sample ...


5
J Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Life Sciences, Donald R McKenna, Ann C Peterson, May 9, 2006: US07041509 (5 worldwide citation)

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and ...


6
J Wallace Parce, Theo T Nikiforov, Tammy Burd Mehta, Anne R Kopf Sill, Andrea W Chow, Michael R Knapp: Sequencing by incorporation. Caliper Life Sciences, Ann C Peterson, Donald R McKenna, March 18, 2008: US07344865 (4 worldwide citation)

Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carb ...


7
Calvin Y H Chow: Total analyte quantitation. Caliper Life Sciences, Ann C Peterson, Donald R McKenna, September 4, 2007: US07264702

Methods for determining total analyte concentrations and amounts, especially in combination with analyte separations are provided. Microfluidic devices are used to separate analyte mixtures and detect the individual analytes. Signal areas are summed for each individual analyte to quantitate the tota ...