1
Pieter R Cullis, Michael J Hope, Marcel B Bally: Extrusion technique for producing unilamellar vesicles. The Liposome Company, Allen Bloom, Catherine Kurtz, Ronald G Ort, April 16, 1991: US05008050 (160 worldwide citation)

A method for reducing the lamellarity of a population of liposomes is provided which comprises repeatedly passing the liposomes under pressure through a filter which has a pore size equal to or less than about 100 nm. In certain embodiments, the method is used to convert a population of previously f ...


2
Louis Seiler Jr, Robert F Rosenbluth: Vascular graft prosthesis. Shiley Incorporated, Charles J Knuth, Peter C Richardson, Allen Bloom, November 5, 1985: US04550447 (151 worldwide citation)

A porous tube suitable for use as a vascular graft prosthesis is disclosed. It is reinforced by external ribs, integral with the tube wall. These ribs are generally transverse to the tube axis and less porous than the wall. Suitable tubing can be made from polymers exhibiting a significant degree of ...


3
Marcel B Bally, Pieter R Cullis, Michael J Hope, Thomas D Madden, Lawrence D Mayer: Encapsulation of antineoplastic agents in liposomes. The Liposome Company, Allen Bloom, Catherine L Kurtz, December 31, 1991: US05077056 (122 worldwide citation)

Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials are provided. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplast ...


4
Michael J Hope, Pieter R Cullis: Induction of asymmetry in vesicles. The Liposome Company, Allen Bloom, Catherine L Kurtz, April 20, 1993: US05204112 (105 worldwide citation)

Methods are described for controlling the transbilayer distribution of ionizable lipids and proteins in vesicles. Control of the ion gradient of the exterior bathing medium in relation to that of the interior entrapped aqueous compartment of the vesicles induces migration of ionizable lipids or prot ...


5
Andrew S Janoff, Pieter R Cullis, Marcel B Bally, Michael W Fountain, Richard S Ginsberg, Michael J Hope, Thomas D Madden, Hugh P Schieren, Regina L Jablonski: Dehydrated liposomes. The Liposome Company, Allen Bloom, Catherine L Kurtz, November 14, 1989: US04880635 (98 worldwide citation)

Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. F ...


6
Andrew S Janoff, Mircea C Popescu, Alan L Weiner, Lois E Bolcsak, Paul S Tremblay: Steroidal liposomes. The Liposome Company, Allen Bloom, Thomas M Saunders, January 26, 1988: US04721612 (92 worldwide citation)

Methods and compositions are described for the preparation of lipid vesicles, the bilayers of which comprise a salt form of an organic acid derivative of a sterol such as the tris-salt form of a sterol hemisuccinate. The method is rapid, efficient, and does not require the use of organic solvents. T ...


7
Jacques I Pankove, Chung P Wu: Method of making selective crystalline silicon regions containing entrapped hydrogen by laser treatment. RCA Corporation, Birgit E Morris, Donald S Cohen, Allen Bloom, March 30, 1982: US04322253 (85 worldwide citation)

A novel hydrogen rich single crystalline silicon material having a band gap energy greater than 1.1 eV can be fabricated by forming an amorphous region of graded crystallinity in a body of single crystalline silicon and thereafter contacting the region with atomic hydrogen followed by pulsed laser a ...


8
Pieter R Cullis, Marcel B Bally, Michael J Hope, Andrew S Janoff, Lawrence D Mayer: Multilamellar liposomes having improved trapping efficiencies. The Liposome Company, Allen Bloom, Catherine L Kurtz, December 4, 1990: US04975282 (81 worldwide citation)

A multilamellar vesicle dispersed in an aqueous phase comprising an aqueous medium, a lipid concentration of at least about 50 mg/ml and a trapping efficiency of at least about 40 percent. The vesicle can be prepared by dispersing the lipid in an aqueous phase to form a multilamellar vesicle, rapidl ...


9
Helen C Loughrey, Pieter R Cullis, Marcel B Bally, Lewis S L Choi, Kim F Wong: Preparation of targeted liposome systems of a defined size distribution. The Liposome Company, Allen Bloom, Catherine Kurtz, October 22, 1991: US05059421 (78 worldwide citation)

The present invention relates to a general method for producing sized protein-liposome conjugates exhibiting enhanced blood circulation times. The present invention also relates to the sized protein-liposome conjugate compositions produced by the method of the present invention. The protein-liposome ...


10
Mircea Popescu, Christine E Swenson, Sterling C Johnson, Robert P Lenk: Therapeutic treatment by intramammary infusion. The Liposome Company, Allen Bloom, Thomas M Saunders, Ronald G Ort, January 1, 1991: US04981692 (78 worldwide citation)

A method of treating, by intramammary infusion of liposomes, Brucella spp. infections in an animal by administration of a therapeutically effective amount of aminoglycoside in liposome form, also being a method of administering a therapeutic agent in liposome form to a proximal mammary lymph node or ...