1
Eric J Mathur: Purified thermostable pyrococcus furiosus DNA polymerase I. Stratagene, Albert P Pennie & Edmonds Halluin Esq, August 13, 1996: US05545552 (43 worldwide citation)

Purified thermostable Pyrococcus furiosus DNA polymerase that migrates on a non-denaturing polyacrylamide gel faster than phosphorylase B and Taq polymerase and more slowly than bovine serum albumin and has an estimated molecular weight of 90,000-93,000 daltons when compared with a Taq polymerase st ...


2
Jay M Short: Nucleic acid construct encoding a nuclear transport peptide operatively linked to an inducible promoter. Stratagene, Albert P Pennie & Edmonds Halluin Esq, December 31, 1996: US05589392 (22 worldwide citation)

A system for regulating expression of eukaryotic genes in cells is described. The system contains two recombinant DNA molecules, a first molecule that encodes a nucleus-targeted inducible repressor polypeptide, and a second molecule that encodes an operator-regulated reporter polypeptide. Transgenic ...


3
Darwin J Prockop, Leena Ala Kokko, Andrzej Fertala, Aleksander Sieron, Kari I Kivirikko, Amy Geddis, Taina Pihlajaniemi: Synthesis of human procollagens and collagens in recombinant DNA systems. Thomas Jefferson University, Albert P Pennie & Edmonds Halluin Esq, January 14, 1997: US05593859 (19 worldwide citation)

The invention is transfected cells, substantially all of which contain at least one human collagen gene and express fibrillar collagen molecules derived using methods for synthesizing collagen and collagen fibrils in said cell lines, and methods for treatment of disorders in humans using said collag ...


4
Orla M Conneely, Denis R Headon, Bert W O Malley, Gregory S May: Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms. Baylor College of Medicine, Albert P Pennie & Edmonds Halluin Esq, August 8, 2000: US06100054 (17 worldwide citation)

The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product.


5
Orla M Conneely, Denis R Headon, Bert W O Malley, Gregory S May: Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms. Baylor College of Medicine, Albert P Pennie & Edmonds Halluin Esq, June 16, 1998: US05766939 (15 worldwide citation)

The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product.


6
Kirk B Nielson, Eric J Mathur: Method for producing primed nucleic acid templates. Stratagene, Albert P Pennie & Edmonds Halluin Esq, July 8, 1997: US05646019 (12 worldwide citation)

The present invention relates to an improved method for producing primed nucleic acid templates. Specifically, it relates to a method, compositions and kits therefor, of increasing the specificity of primer extension reactions by hybridizing primer to template in the presence of single-stranded nucl ...


7
Kirk B Nielson, Eric J Mathur: Composition for hybridizing nucleic acids using single-stranded nucleic acid binding protein. Stratagene, Albert P Pennie & Edmonds Halluin Esq, February 25, 1997: US05605824 (12 worldwide citation)

The present invention relates to an improved composition for hybridizing polynucleotides with complementary nucleic acid sequences. Specifically, it relates to a composition for of increasing the specificity of a polynucleotide hybridization reaction in the presence of single-stranded nucleic acid b ...


8
James M Wilson, Richard C Mulligan: Modified hepatocytes and uses therefor. Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Albert P Pennie & Edmonds Halluin Esq, December 3, 1996: US05580776 (7 worldwide citation)

Genetically engineered or transduced hepatocytes which express genetic material of interest introduced or incorporated into them, as well as methods of producing, transplanting and using the genetically engineered hepatocytes. The genetic material of interest can be incorporated through use of a vec ...


9
Christopher M Starr: Utilization of additives and defined storage systems to increase the stability and performance of electrophoresis media. Glyko Incorporated, Albert P Pennie & Edmonds Halluin Esq, February 10, 1998: US05716508 (5 worldwide citation)

The present invention relates to an electrophoresis media comprising a gel and a compound capable of restricting the diffusion of water within the gel. Diffusion restricting compounds useful in the present invention include but are not limited to polyols, polymeric alcohols, polysaccharides, polyoxy ...


10
Harvey I Miller, John C Klock, Christopher M Starr: Polynucleotides encoding .alpha.2-3 neuraminidase. Glyko, Albert P Pennie & Edmonds Halluin Esq, January 7, 1997: US05591839 (4 worldwide citation)

Polynucleotide sequences encoding enzymes that possess .alpha.2-3 neuraminidase activity are provided. Of particular interest are polynucleotide sequences encoding an enzyme having .alpha.2-3 neuraminidase activity and naturally produced by the bacteria Streptococcus pneumoniae. Recombinant DNA expr ...



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