1
Kary B Mullis: Process for amplifying nucleic acid sequences. Cetus Corporation, Janet E Hasak, Albert P Halluin, July 28, 1987: US04683202 (4203 worldwide citation)

The present invention is directed to a process for amplifying any desired specific nucleic acid sequence contained in a nucleic acid or mixture thereof. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, and extending ...


2
Kary B Mullis, Henry A Erlich, Norman Arnheim, Glenn T Horn, Randall K Saiki, Stephen J Scharf: Process for amplifying, detecting, and/or-cloning nucleic acid sequences. Cetus Corporation, Janet E Hasak, Albert P Halluin, July 28, 1987: US04683195 (3575 worldwide citation)

The present invention is directed to a process for amplifying and detecting any target nucleic acid sequence contained in a nucleic acid or mixture thereof. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, extending ...


3
Kary B Mullis, Henry A Erlich, Norman Arnheim, Glenn T Horn, Randall K Saiki, Stephen J Scharf: Process for amplifying, detecting, and/or cloning nucleic acid sequences. Cetus Corporation, Kevin R Kaster, Janet E Hasak, Albert P Halluin, January 24, 1989: US04800159 (1164 worldwide citation)

The present invention is directed to a process for amplifying and detecting any target nucleic acid sequence contained in a nucleic acid or mixture thereof. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, extending ...


4
David H Gelfand, Susanne Stoffel, Frances C Lawyer, Randall K Saiki: Purified thermostable enzyme. Cetus Corporation, Janet E Hasak, Kevin R Kaster, Albert P Halluin, December 26, 1989: US04889818 (435 worldwide citation)

A purified thermostable enzyme is obtained that has unique characteristics. Preferably the enzyme is isolated from the Thermus aquaticus species and has a molecular weight of about 86,000-90,000 daltons. The thermostable enzyme may be native or recombinant and may be used in a temperature-cycling ch ...


5
Robert S Ward, Kathleen A White: Surface-modifying endgroups for biomedical polymers. The Polymer Technology Group, Albert P Halluin, Richard J Pennie & Edmonds Gallagher, December 31, 1996: US05589563 (354 worldwide citation)

The present invention relates to novel polymeric compositions of matter and their use. Said polymeric compositions of matter are surface active endgroup-containing polymers that comprise a linear base polymer having covalently bonded surface active endgroups of a nature and present in an amount such ...


6
Nandini Katre, Michael J Knauf: Solubilization of proteins for pharmaceutical compositions using polymer conjugation. Cetus Corporation, Albert P Halluin, Janet E Hasak, August 23, 1988: US04766106 (302 worldwide citation)

A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is not water-soluble or not r ...


7
Randall K Saiki, Henry A Erlich: Method for detection of polymorphic restriction sites and nucleic acid sequences. Cetus Corporation, Janet E Hasak, Albert P Halluin, July 28, 1987: US04683194 (292 worldwide citation)

In a method for detecting the presence or absence of a specific restriction site in a nucleic acid sequence an oligonucleotide probe complementary to one strand of the nucleic acid sequence spanning said restriction site is synthesized. The probe is labeled at the end nearer the restriction site. Th ...


8
Rong Chang Liang, Scott C J Tseng, Zarng Arh George Wu, HongMei Zang, Hsiao Ken Chuang: Electrophoretic display and novel process for its manufacture. SiPix Imaging, Albert P Halluin, Viola T Kung, Howrey Simon Arnold & White, September 7, 2004: US06788449 (277 worldwide citation)

This invention relates to an electrophoretic display comprising cells of well-defined shape, size and aspect ratio which cells are filled with charged pigment particles dispersed in a solvent, and novel processes for its manufacture.


9
Jorma Virtanen: Laboratory in a disk. Burstein Laboratories, Albert P Halluin, J David Howrey & Simon Smith, February 29, 2000: US06030581 (230 worldwide citation)

An apparatus is described that includes an optical disk, adapted to be read by an optical reader, comprising a first sector having substantially self-contained assay means for localizing an analyte suspected of being in a sample to at least one, predetermined location in the first sector and a secon ...


10
David F Mark, Leo S Lin, Shi da Yu Lu, Alice M Wang: Cysteine-depleted muteins of biologically active proteins. Cetus Corporation, Albert P Halluin, Jane R McLaughlin, Kate H Murashige, September 25, 1990: US04959314 (229 worldwide citation)

Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. ...