1
Allard Jeffrey W, Cristofanilli Massimo, Terstappen Leon W M M: Circulating tumor cells (ctc’s): early assessment of time to progression survival and response to therapy in metastatic cancer patients. Immunivest Corporation, Allard Jeffrey W, Cristofanilli Massimo, Terstappen Leon W M M, ACETO Joseph, September 10, 2004: WO/2004/076643 (35 worldwide citation)

A cancer test having prognostic utility in predicting time to disease progression, overall survival, and response to therapy in patients with MBC based upon the presence and number of CTC's. The Cell Spotter® System is used to enumerate CTC's in blood. The system immunomagnetically concentrates epit ...


2
Bendele Teresa, Harbart Thomas, Howard Dave, Kagan Michael, Keene Douglas, Lapeus Dave, Mayes Jared, Paynter Douglas, Prohaska Jerry, Rutner Herman: Operator independent programmable sample preparation and analysis system. Immunivest Corporation, Bendele Teresa, Harbart Thomas, Howard Dave, Kagan Michael, Keene Douglas, Lapeus Dave, Mayes Jared, Paynter Douglas, Prohaska Jerry, Rutner Herman, ACETO Joseph, March 31, 2005: WO/2005/028663 (34 worldwide citation)

The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously ...


3
Larson Christopher J, Terstappen Leon W M M, Moreno Jose G, Pienta Kenneth J, Repollet Madeline L: Circulating tumor cells (ctc’s): apoptotic assessment in prostate cancer patients. Immunivest Corporation, Larson Christopher J, Terstappen Leon W M M, Moreno Jose G, Pienta Kenneth J, Repollet Madeline L, ACETO Joseph, April 20, 2006: WO/2006/041453 (25 worldwide citation)

A method for detecting and enumerating apoptotic cancer cells in a mixed cell population by obtaining a biological specimen, the presence of said cancer cells in said population being indicative of a diseases state, is provided. The method comprises obtaining a biological specimen from a test subjec ...


4
Doyle Gerald V, O Hara Shawn Mark, Rutner Herman: Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection. Immunivest Corporation, Doyle Gerald V, O Hara Shawn Mark, Rutner Herman, ACETO Joseph, May 26, 2006: WO/2006/054991 (24 worldwide citation)

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry, CellSpotterTM fluorescent microscopy imaging andmass spectrometric profiling. In addition to ...


5
Terstappen Leon W M M, Uhr Jonathan W: A blood test to monitor the genetic changes of progressive cancer using immunomagnetic enrichment and fluorescence in situ hybridization (fish). Immunivest Corporation, Terstappen Leon W M M, Uhr Jonathan W, Board Of Regents, ACETO Joseph, December 8, 2005: WO/2005/116264 (22 worldwide citation)

Amplification and overexpression of theHER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between the primary tumor and metastases. Therefore, patients with HER-2 negative primary tumors will rarely receive anti-HER-2 antibody therapy. A very sensitive foo ...


6
Gross Steven, Rutner Herman: Method and apparatus for pre-enrichment and recovery of cells from densified whole blood. Immunivest Corporation, Gross Steven, Rutner Herman, ACETO Joseph, June 2, 2005: WO/2005/049168 (22 worldwide citation)

The present invention describes reagents, methods and apparatus for pre-processing of blood samples to obtain blood fractions containing substantially all target cells in reduced specimen volumes that are suitable for subsequent further enrichment. Sample processor systems are described for enrichin ...


7
Tycho Scholtens, Leon W M M Terstappen, Arjan Tibbe: Magnetic separation apparatus and methods. Immunivest Corporation, Tycho Scholtens, Leon W M M Terstappen, Arjan Tibbe, ACETO Joseph, July 7, 2005: WO/2005/061075 (20 worldwide citation)

Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic ca ...


8
O Hara Shawn Mark, Smimov Denis: Methods for the determination of cell specific biomarkers. Immunivest Corporation, O Hara Shawn Mark, Smimov Denis, ACETO Joseph, October 20, 2005: WO/2005/098046 (19 worldwide citation)

The present invention provides methods for the reduction of the considerate amount of white cell background that interferes with meaningful analysis of a patient's food sample when the analysis involves rare cell analysis. Nucleic acid profile analysis of targeted rare cells is obtained from an indi ...


9
Tibbe Arjan, Terstappen Leon W M M: Method and apparatus for imaging target components in a biological sample using permanent magnets. Immunivest Corporation, Tibbe Arjan, Terstappen Leon W M M, ACETO Joseph, September 28, 2006: WO/2006/102233 (15 worldwide citation)

A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, all cells in a biological sample are fl ...


10
Coumans Frank A W, Marlin Arthur G, Modica Frank P, Verrant John A: A diagnostic imaging device for the analysis of circulating rare cells. Immunivest Corporation, Coumans Frank A W, Marlin Arthur G, Modica Frank P, Verrant John A, ACETO Joseph, March 2, 2006: WO/2006/023563 (15 worldwide citation)

The present invention provides a system for imaging circulating tumor cells from blood after enrichment. The system is designed to provide optimum use in a clinical laboratory setting with minimum laboratory bench top space. Operator intervention is minimized compared to other analytical methodologi ...