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Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Boehringer Ingelheim International, Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank, DAVIS Steven G, November 5, 2009: WO/2009/134400 (46 worldwide citation)

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibit ...


2
Wai John S, Kim Boyoung, Fisher Thorsten E, Zhuang Linghang, Williams Peter D, Lyle Terry A, Langford H Marie, Robinson Kyle A: Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors. Merck & Co, Wai John S, Kim Boyoung, Fisher Thorsten E, Zhuang Linghang, Williams Peter D, Lyle Terry A, Langford H Marie, Robinson Kyle A, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, March 25, 2004: WO/2004/024078 (45 worldwide citation)

8,9-Dihydroxydihydropyridopyrazine-1,6-diones and 8,9-dihydroxypyridopyrazine-1,6-diones are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the pyridopyrazinediones are of Formula (I): (I),wherein R1, R2, R3, R4 and R5 are defined herein. The compounds are useful i ...


3
Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M: 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11β -hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, DAVIS Steven Get al, August 20, 2009: WO/2009/102428 (39 worldwide citation)

This invention relates to novel compounds of the Formula (I)1 (I*), (I**), (Ia), (Ib), (Ic), (Id), (Ie)1 (If), (Ig), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibi ...


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Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Mcgeehan Gerard: Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Vitae Pharmaceuticals, Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Mcgeehan Gerard, DAVIS Steven G, September 24, 2009: WO/2009/117109 (38 worldwide citation)

This invention relates to novel compounds of the Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals.


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Himmelsbach Frank, Claremon David A, Zhuang Linghang, Leftheris Katerina, Xu Zhenrong, Tice Colin M: Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1. Boehringer Ingelheim International, Vitae Pharmaceuticals, Himmelsbach Frank, Claremon David A, Zhuang Linghang, Leftheris Katerina, Xu Zhenrong, Tice Colin M, Abelleira Susan M, January 28, 2010: WO/2010/011314 (37 worldwide citation)

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibit ...


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Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Simpson Robert D: Inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, Zhuang Linghang, Ye Yuanjie, Singh Suresh B, Tice Colin M, Simpson Robert D, DAVIS Steven Get al, August 20, 2009: WO/2009/102460 (37 worldwide citation)

This invention relates to novel compounds of the Formula (I), any of the formulas I1-I26 Ia1-3-lj1-3 or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β- ...


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Claremon David A, He Wei, Mcgeehan Gerard, Singh Suresh B, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Zhao Wei, Zhuang Linghang, Cacatian Salvacion, Leftheris Katerina: Cyclic inhibitors of 11β-hydroxysteriod dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, He Wei, Mcgeehan Gerard, Singh Suresh B, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Zhao Wei, Zhuang Linghang, Cacatian Salvacion, Leftheris Katerina, DAVIS Steven G, February 5, 2009: WO/2009/017664 (33 worldwide citation)

This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih); (Ii); (Ij), (Ik), (II) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modu ...


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Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Ye Yuanjie, Singh Suresh B, Himmelsbach Frank: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Boehringer Ingelheim International, Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Ye Yuanjie, Singh Suresh B, Himmelsbach Frank, DAVIS Steven G, November 5, 2009: WO/2009/134387 (29 worldwide citation)

This invention relates to novel compounds of the Formula I1 Ik, Im3, Im4, Im6-12, In3, In4, In6-12, lo3, lo4, lo6-12, Ip2, Ip4-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulat ...


9
Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Ye Yuanjie, Singh Suresh B: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Ye Yuanjie, Singh Suresh B, DAVIS Steven G, November 5, 2009: WO/2009/134384 (28 worldwide citation)

This invention relates to novel compounds of the Formula (I), (II), lu1-20, Iv1-20, Iw1-20, Ix1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 1 β-HSD1 i ...


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Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank, Eckhardt Matthias: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Boehringer Ingelheim International, Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank, Eckhardt Matthias, DAVIS Steven G, November 5, 2009: WO/2009/134392 (28 worldwide citation)

This invention relates to novel compounds of the Formula I, Ik, Iq1-21, Ir1-21, Is1-21, It1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in m ...