1
David C Ward, Pennina R Langer, Alexander A Waldrop III: Modified nucleotides and methods of preparing and using same. Yale University, James F Haley Jr, December 8, 1987: US04711955 (532 worldwide citation)

Compounds having the structure: ##STR1## wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1' -position of the sugar moiety, provided that when B is purine or 7-deazapurine, it is attached at the N.sup.9 -position of the purine or 7-deazapurine and whe ...


2
Paul M Lizardi: Rolling circle replication reporter systems. Yale University, Arnall Golden & Gregory, December 29, 1998: US05854033 (442 worldwide citation)

Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic acids in a sample with high specificity and sensitivity. The method also has an inherently low level of bac ...


3
Manohar M Panjabi: Spinal stabilization method. Yale University, McCarter & English, April 18, 2006: US07029475 (337 worldwide citation)

A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured spine. The dynamic spine stabilizer includes a support assembly and a resistance assembly associated with th ...


4
Eric Freeman, David H Gelernter: Document stream operating system. Yale University, Cooper & Dunham, December 21, 1999: US06006227 (247 worldwide citation)

A document stream operating system and method is disclosed in which: (1) documents are stored in one or more chronologically ordered streams; (2) the location and nature of file storage is transparent to the user; (3) information is organized as needed instead of at the time the document is created; ...


5
Sherman M Weissman, Dennis Pereira, Ashwani Sood: Method for cloning genes. Yale University, Millen & White, July 19, 1983: US04394443 (220 worldwide citation)

A method is provided for isolating and identifying a recombinant clone having a DNA segment therein coding for at least one desired heterologous polypeptide, at least a short amino acid sequence of which is known, by effecting cDNA synthesis on a mixture of mRNAs containing the mRNA coding for the d ...


6
Lawrence I Deckelbaum: Laser ablation process and apparatus. Yale University, Darby & Darby, November 22, 1988: US04785806 (215 worldwide citation)

A process and apparatus for ablating atherosclerotic or tumorous tissues is disclosed. Optical fibers direct low power light energy at a section of tissue to be ablated to cause the section to fluoresce. The fluorescence pattern is analyzed to determine whether the fluorescence frequency spectrum is ...


7
David C Ward, Pennina R Langer, Alexander A Waldrop III: Methods of using labeled nucleotides. Yale University, Mary J Morry, Eugene Moroz, Ronald C Fedus, July 12, 1994: US05328824 (201 worldwide citation)

Compounds having the structure: ##STR1## wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1' -position of the sugar moiety, provided that when B is purine or 7-deazapurine, it is attached at the N.sup.9 -position of the purine or 7-deazapurine and whe ...


8
John K Rose: Liposomal transfection of nucleic acids into animal cells. Yale University, Frishauf Holtz Goodman & Woodward, January 18, 1994: US05279833 (186 worldwide citation)

A reagent for introducing a nucleic acid into an animal cell. The reagent comprises (a) a neutral lipid such as dioleoylphosphatidylethanolamine and (b) a cationic lipid selected from the group consisting of an ammonium salt such as dimethyldioctadecylammonium bromide or cetyldimethylethylammonium b ...


9
Paul M Lizardi, Michael Caplan: Unimolecular segment amplification and sequencing. Yale University, Arnall Golden & Gregory, November 7, 2000: US06143495 (179 worldwide citation)

Disclosed are compositions and a method for amplification of and multiplex detection of molecules of interest involving rolling circle replication. The method is useful for simultaneously detecting multiple specific nucleic acids in a sample with high specificity and sensitivity. The method also has ...


10
David C Ward, Pennina R Langer, Alexander A Waldrop III: Modified polynucleotides and methods of preparing same. Yale University, Ronald C Fedus, John L Santalone, September 12, 1995: US05449767 (160 worldwide citation)

Compounds having the structure: ##STR1## wherein B represents 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1 '-position of the sugar moiety, provided that when B is 7-deazapurine, it is attached at the N.sup.9 -position of the 7-deazapurine and when B is pyrimidine, it is attac ...