1
Jia Ning Xiang, Mark A Gallop, Kenneth C Cundy, Jianhua Li, Feng Xu, Cindy X Zhou, Laxminarayan Bhat: Carbidopa prodrugs and derivatives, and compositions and uses thereof. XenoPort, Finnegan Henderson Farabow Garrett & Dunner, September 5, 2006: US07101912 (54 worldwide citation)

Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed.


2
Archana Gangakhedkar, Xuedong Dai, Noa Zerangue, Peter A Virsik: Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use. XenoPort, Polsinelli PC, July 15, 2014: US08778991 (43 worldwide citation)

Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel ...


3
Mark A Gallop, Ge Peng, Thomas F Woiwode, Kenneth C Cundy: Gemcitabine prodrugs, pharmaceutical compositions and uses thereof. XenoPort, Dorsey & Whitney, September 4, 2007: US07265096 (36 worldwide citation)

The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as cancer or viral infecti ...


4
Mark A Gallop, Xuedong Dai, Randall A Scheuerman, Stephen P Raillard, Suresh K Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat: Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof. XenoPort, Dorsey & Whitney, June 5, 2007: US07227028 (34 worldwide citation)

Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful int ...


5
Mark A Gallop, Kenneth C Cundy, Cindy X Zhou, Fenmei Yao, Jia Ning Xiang: Prodrugs of GABA analogs, compositions and uses thereof. Xenoport, Sunil K Singh, Cooley Godward, November 16, 2004: US06818787 (30 worldwide citation)

The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodru ...


6
Stephen P Raillard, Cindy X Zhou, Fenmei Yao, Suresh Kumar Manthati, Jia Ning Xiang, Mark A Gallop: Methods for synthesis of acyloxyalkyl derivatives of GABA analogs. Xenoport, Dorsey & Whitney, June 19, 2007: US07232924 (22 worldwide citation)

The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.


7
Gallop Mark A, Peng Ge, Woiwode Thomas F, Cundy Kenneth C: Gemcitabine prodrugs, pharmaceutical compositions and uses thereof. Xenoport, SINGH Sunil K, May 21, 2004: WO/2004/041203 (22 worldwide citation)

The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as cancer or viral infecti ...


8
Mark A Gallop, Kenneth C Cundy, Cindy X Zhou, Fayang Gregory Qiu, Fenmei Yao, Jia Ning Xiang, Ian R Ollman: Prodrugs of GABA analogs, compositions and uses thereof. Xenoport, Richard F Trecartin Esq, Dorsey & Whitney, March 6, 2007: US07186855 (20 worldwide citation)

The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodru ...


9
Mark A Gallop, Fenmei Yao, Maria J Ludwikow, Thu Phan, Ge Peng: Acyloxyalkyl carbamate prodrugs, methods of synthesis and use. XenoPort, Richard F Trecartin Esq, Dorsey & Whitney, September 19, 2006: US07109239 (19 worldwide citation)

The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs ...


10
Noa Zerangue, Bernd Jandeleit, Yunxiao Li, Mark A Gallop: Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use. XenoPort, Finnegan Henderson Farabow Garrett & Dunner, April 1, 2008: US07351740 (18 worldwide citation)

Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl) -cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl) -cyclohexanecarboxylic acid and pharmaceu ...