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Dey Kaka, Gao Donghong Amy, Goldberg Daniel R, Heim Riether Alexander, Mangette John E, Mugge Ingo Andreas, Snow Roger, Swinamer Alan David, Wu Jiang Ping, Xiong Zhaoming, Yang Yu: Ccr10 antagonists. Boehringer Ingelheim International, Boehringer Ingelheim Pharma & Co Kg, Dey Kaka, Gao Donghong Amy, Goldberg Daniel R, Heim Riether Alexander, Mangette John E, Mugge Ingo Andreas, Snow Roger, Swinamer Alan David, Wu Jiang Ping, Xiong Zhaoming, Yang Yu, MORRIS Michael P, April 23, 2009: WO/2009/052078 (21 worldwide citation)

The invention relates to a compound of formula (I) or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various di ...


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Kelly Terence Alfred, Bormann Barbara Jean, Frye Leah Lynn, Wu Jiang Ping: Small molecules useful in the treatment of inflammatory disease. Boehringer Ingelheim Pharmaceuticals, Kelly Terence Alfred, Bormann Barbara Jean, Frye Leah Lynn, Wu Jiang Ping, RAYMOND Robert P, September 11, 1998: WO/1998/039303

A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of structural formulas (a), (b), (c), (d), (e) and (f).


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Gao Donghong Amy, Moss Neil, Wang Ji, Wu Jiang Ping, Wu Lifen, Xiong Zhaoming: Cytokine inhibitors. Boehringer Ingelheim Pharmaceuticals, Gao Donghong Amy, Moss Neil, Wang Ji, Wu Jiang Ping, Wu Lifen, Xiong Zhaoming, MORRIS Michael P, March 9, 2006: WO/2006/026235

Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compound ...