1
Lin Herbert Y, Babitt Jodie, Chung Raymond T, Samad Tarek A, Schneyer Alan L, Woolf Clifford: Use of modulatirs of compounds of tgf-beta superfamily to regulate hepcidin-mediated iron metabolism. The General Hospital Corporation, Lin Herbert Y, Babitt Jodie, Chung Raymond T, Samad Tarek A, Schneyer Alan L, Woolf Clifford, ELBING Karen L, August 24, 2006: WO/2006/088972 (34 worldwide citation)

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-&bgr; superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. ...


2
Bean Bruce P, Woolf Clifford J: Methods, compositions, and kits for treating pain and pruritis. President And Fellows Of Harvard College, The General Hospital Corporation, Bean Bruce P, Woolf Clifford J, BELLIVEAU Michael J, September 17, 2009: WO/2009/114139 (11 worldwide citation)

The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while minimizing effects on non-pain-sensing neurons or other types of cells.


3
Woolf Clifford, D Urso Donatella, Befort Katia, Costigan Michael: Nucleic acid and amino acid sequences involved in pain. The General Hospital Corporation, Bayer, Woolf Clifford, D Urso Donatella, Befort Katia, Costigan Michael, WILLIAMS Kathleen Madden, February 27, 2003: WO/2003/016475 (7 worldwide citation)

The present invention relates to nucleic acid sequences which are related to pain and which are differentially expressed during pain. The invention further relates to methods of identifying nucleic acid sequences which are differentially expressed during pain, microarrays comprising such differentia ...


4
Bean Bruce P, Woolf Clifford J: Methods, compositions, and kits for treating pain and pruritis. President And Fellows Of Harvard College, The General Hospital Corporation, Bean Bruce P, Woolf Clifford J, BELLIVEAU Michael J, May 29, 2008: WO/2008/063603 (5 worldwide citation)

The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage- ...


5
Ma Qiufu, Chen Chih Li, Woolf Clifford J, Broom Daniel C: Regulation of runx1 for treatment of pain. Dana Farber Cancer Institute, The General Hospital Corporation, Ma Qiufu, Chen Chih Li, Woolf Clifford J, Broom Daniel C, STEELE Alan W, September 14, 2006: WO/2006/096498 (3 worldwide citation)

Methods are provided for identifying candidate agents for use in inhibiting expression of certain receptors and ion channels in nociceptors. Also provided are methods for identifying candidate agents for use in inhibiting neuropathic and other types of pain.


6
Woolf Clifford J: Compositions and methods for preventing abuse of orally administered medications. The General Hospital Corporation, Woolf Clifford J, ELBING Karen L, November 13, 2003: WO/2003/092676 (3 worldwide citation)

Disclosed herein is the use of chemical irritants, such as vanilloid receptor-1 agonists, in sustained/controlled release pharmaceutical preparations which also contain a drug typically having high abuse potential. Inclusion of the VR1 agonist in the pharmaceutical preparation interferes with illici ...


7
Lin Herbert Y, Babitt Jodie, Woolf Clifford J, Samad Tarek A: Hemojuvelin fusion proteins and uses thereof. The General Hospital Corporation, Lin Herbert Y, Babitt Jodie, Woolf Clifford J, Samad Tarek A, EISENSTEIN Ronald I, October 16, 2008: WO/2008/124768 (2 worldwide citation)

The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a HJV fusion prote ...


8
Woolf Clifford J, Costigan Michael, Max Mitchell B, Belfer Inna, Atlas Steven J, Kingman Albert, Wu Tianxia, Goldman David: Diagnostic methods for pain sensitivity and chronicity and for tetrahydrobiopterin-related disorders. The General Hospital Corporation, National Institutes Of Health, Woolf Clifford J, Costigan Michael, Max Mitchell B, Belfer Inna, Atlas Steven J, Kingman Albert, Wu Tianxia, Goldman David, ELBING Karen L, June 14, 2007: WO/2007/067263 (1 worldwide citation)

Disclosed herein are methods for determining whether a subject possesses altered pain sensitivity an altered risk of developing acute or chronic pain, or diagnosing a tetrahydrobiopterin (BH4)-related disorder or a propensity thereto. These methods are based on the discovery of GCHl and KCNSl alleli ...


9
Woolf Clifford J, Scholz Joachim, Decosterd Isabelle Veronique, Abdi Salahadin: Pain assessment. The General Hospital Corporation, Woolf Clifford J, Scholz Joachim, Decosterd Isabelle Veronique, Abdi Salahadin, LEBER Celia H, December 24, 2003: WO/2003/105686

A sequence of step in providing a mechanism-based pain assessment includes: acquiring data (210), generating a pain profile for the patient (212), identifying pain feature(s) (214), and from the pain feature(s), identifying the corresponding pain mechanism(s) responsible for the patient’s pain (216. ...


10
Woolf Clifford, D Urso Donatella, Costigan Michael: Nucleic acid and amino acid sequences involved in pain. The General Hospital Corporation, Woolf Clifford, D Urso Donatella, Costigan Michael, WILLIAMS Kathleen M, July 7, 2005: WO/2005/060667

The present invention relates to nucleic acid sequences which are related to pain and which are differentially expressed during pain. The invention further relates to methods of identifying nucleic acid sequences which are differentially expressed during pain, microarrays comprising such diffrential ...