1
Wong Chi Huey, Brik Ashraf, Yang Yu Ying, Ficht Simon, Payne Richard: Method of preparing glycopeptides. The Scripps Research Institute, Wong Chi Huey, Brik Ashraf, Yang Yu Ying, Ficht Simon, Payne Richard, STEFFEY Charles E, October 4, 2007: WO/2007/111952 (17 worldwide citation)

A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coupled with a C-terminal peptide portion bearing a carbohydrate moiety comprising a thiol group.


2
Wong Chi Huey, Fang Jim Min, Shie Jiun Jie, Cheng Yih Shyun Edmond, Jan Jia Tsrong: Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity. Wong Chi Huey, Fang Jim Min, Shie Jiun Jie, Cheng Yih Shyun Edmond, Jan Jia Tsrong, WALKER Marlan D, March 5, 2009: WO/2009/029888 (6 worldwide citation)

Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug ...


3
WONG Chi Huey, FANG Jim Min, CHENG Yih Shyun, SHIE Jiun Jie: Congénères de phosphonate de zanamivir ayant une activité antigrippale et détermination de la sensibilité à loseltamivir dinfluenzavirus, Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses. WONG Chi Huey, FANG Jim Min, CHENG Yih Shyun, SHIE Jiun Jie, Sinica Academia, BASU Shantanu, November 17, 2011: WO/2011/143262 (6 worldwide citation)

Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non- oseltamivir influenza virus neuraminidase inhibitors and oseltamivir ...


4
Wong Chi Huey, Wu Doug, Fujio Masakazu, Tsuji Moriya, Ho David: Glycolipids and analogues thereof as antigens for nk t cells. The Rockefeller University, Wong Chi Huey, Wu Doug, Fujio Masakazu, Tsuji Moriya, Ho David, The Scripps Research Institute, BELL Charles E, July 6, 2006: WO/2006/071848 (5 worldwide citation)

This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.


5
Wong Chi Huey, Hsu Hsien Yeh, Hua Kuo Feng, Lin Chun Hung, Hsu Jason, Chen Shui Tein, Lin Kuo I, Yang Wen bin, Yu John, Yu Alice: Methods and compositions associated with administration of an extract of ganoderma lucidum. Academia Sinica, Wong Chi Huey, Hsu Hsien Yeh, Hua Kuo Feng, Lin Chun Hung, Hsu Jason, Chen Shui Tein, Lin Kuo I, Yang Wen bin, Yu John, Yu Alice, BRUNO Enrica, April 27, 2006: WO/2006/044616 (5 worldwide citation)

A fucose-containing glycoprotein fraction obtainable from an extract of Ganoderma Lucidum Reishi, compositions comprising the fuconse-containing glycoprotein fraction, a method to mediate immunomodulating events associated with IL-1 gene expression, a method to stimulate the expression of an inflamm ...


6
WONG Chi Huey, WU Chung Yi, LIANG Chi Hui, YANG An Suei: Puces au glycane pour la recherche par criblage haut débit de virus, Glycan arrays for high throughput screening of viruses. Academia Sinica, WONG Chi Huey, WU Chung Yi, LIANG Chi Hui, YANG An Suei, BASU Shantanu, October 20, 2011: WO/2011/130332 (5 worldwide citation)

Glycan arrays that can detect and distinguish between various sub-types and strains of influenza virus are provided. Methods for using the glycan arrays with assays using nanoparticle amplification technique are disclosed. Sandwich assays using gold nanoparticles conjugated to phage particles compri ...


7
Wong Chi Huey, Yu Alice, Chang Ya Jen, Lin Kun Hsien, Cheng Y S Edmond, Jan Jia Tsrong, Lin Yi Ling, Hung Jung Tung: Alpha-galactosyl ceramide analogs and their use as immunotherapies, adjuvants, and intiviral, antibacterial, and anticancer agents. Academia Sinica, Wong Chi Huey, Yu Alice, Chang Ya Jen, Lin Kun Hsien, Cheng Y S Edmond, Jan Jia Tsrong, Lin Yi Ling, Hung Jung Tung, Krietzman Mark, January 14, 2010: WO/2010/006315 (5 worldwide citation)

The present disclosure relates to synthetic alpha-galactosyl ceramide (α- GalCer) analogs, and their use as immunotherapies, adjuvants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amou ...


8
Wong Chi Huey, Wu Chung Yi, Tseng Susan Y: Glycan arrays on ptfe-like aluminum coated glass slides and related methods. Academia Sinica, Wong Chi Huey, Wu Chung Yi, Tseng Susan Y, Walker Marlan, January 21, 2010: WO/2010/009271 (5 worldwide citation)

Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examin ...


9
Wong Chi Huey, Hsu Hsien Yeh, Hua Kuo Feng, Lin Chun Hung, Hsu Jason, Chen Shui Tein, Lin Kuo I, Yang Wen bin, Yu John, Yu Alice: Methods and compositions associated with administration of an extract of ganoderma lucidum. Academia Sinica, Wong Chi Huey, Hsu Hsien Yeh, Hua Kuo Feng, Lin Chun Hung, Hsu Jason, Chen Shui Tein, Lin Kuo I, Yang Wen bin, Yu John, Yu Alice, HIRD Steven N, April 26, 2007: WO/2007/047021 (4 worldwide citation)

The present disclosure provides methods for increasing the lipopolysaccharide-induced secretion of IL-1 by macrophages, for increasing serum levels of IL-1 in a mammal, for increasing the serum level of IL-1 receptor antagonist (IL-1Ra) in a mammal, for increasing the secretion of IL-1 by a monocyte ...


10
Tzu Bi, Shin Daniel, Chen Wan Yu, Wong Chi Huey: Reishi-mediated enhancement of human tissue progenitor cell adhesion and differentiation. Academia Sinica, Tzu Bi, Shin Daniel, Chen Wan Yu, Wong Chi Huey, KRIETZMAN Mark, March 27, 2008: WO/2008/036421 (4 worldwide citation)

The present disclosure provides medicinally active extracts and fractions, and methods for using the same to increase eukaryotic cell adhesion, to increase differentiation of eukaryotic cells to produce increased numbers of B cells dendritic cells and chodrocytes, and to maintain undifferentiated he ...