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George Dawn M, Dixon Richard W, Friedman Michael, Hobson Adrian, Li Biqin, Wang Lu, Wu Xiaoyun, Wishart Neil: Aminopyrrolidines as chemokine receptor antagonists. Abbott Laboratories, George Dawn M, Dixon Richard W, Friedman Michael, Hobson Adrian, Li Biqin, Wang Lu, Wu Xiaoyun, Wishart Neil, O BRIEN Gayle, May 22, 2008: WO/2008/060621 (7 worldwide citation)

The present invention is directed to novel aminopyrrolidines of formula (I), pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine ...


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Hirst Gavin C, Calderwood David, Wishart Neil, Rafferty Paul, Ritter Kurt, Arnold Lee D, Friedman Michael M: Pyrazolopyrimidines as therapeutic agents. Basf Aktiengesellschaft, Hirst Gavin C, Calderwood David, Wishart Neil, Rafferty Paul, Ritter Kurt, Arnold Lee D, Friedman Michael M, DECONTI Giulio A, March 22, 2001: WO/2001/019829 (2 worldwide citation)

The present invention provides compounds of Formula (I), including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R¿a?, R¿2?, R¿3? are defined as described herein and their use as protein Kinase inhibitors.


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WOLLER Kevin R, CURTIN Michael L, FRANK Kristine E, JOSEPHSOHN Nathan S, LI Biqin C, WISHART Neil: Nouveaux composés de pyrazolo[3,4-d]pyrimidine, NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS. Abbott Laboratories, WOLLER Kevin R, CURTIN Michael L, FRANK Kristine E, JOSEPHSOHN Nathan S, LI Biqin C, WISHART Neil, O BRIEN Gayle B, December 15, 2011: WO/2011/156698 (2 worldwide citation)

The present disclosure is directed to novel compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such ...


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Hirst Gavin C, Arnold Lee D, Burchat Andrew, Wishart Neil, Calderwood David, Wada Carol K, Michaelides Michael R, Ji Zhiqin, Muckey Melanie: Kinase inhibitors. Abbott Laboratories, Hirst Gavin C, Arnold Lee D, Burchat Andrew, Wishart Neil, Calderwood David, Wada Carol K, Michaelides Michael R, Ji Zhiqin, Muckey Melanie, O BRIEN Gayle B, October 2, 2003: WO/2003/080064 (2 worldwide citation)

The present application is directed to pyrazolopyrimidine and furopyrimidine analogs of the formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.