1
Philip L Felgner, Jon A Wolff, Gary H Rhodes, Robert W Malone, Dennis A Carson: Delivery of exogenous DNA sequences in a mammal. VICAL Incorporated, Wisconsin Alumni Research Foundation, Knobbe Martens Olson & Bear, December 3, 1996: US05580859 (722 worldwide citation)

Polynucleotide sequences, comprising DNA and RNA molecules can be directly administered, for example by injection, to tissues, such as muscle, and expressed as a protein, polypeptide or polypeptide. The polynucleotides can be contained within liposomes or the polynucleotides can free from associatio ...


2
Philip L Felgner, Jon A Wolff, Gary H Rhodes, Robert W Malone, Dennis A Carson: Induction of a protective immune response in a mammal by injecting a DNA sequence. Vical Incorporated, Wisconsin Alumni Research Foundation, Knobbe Martens Olson & Bear, December 31, 1996: US05589466 (507 worldwide citation)

A method for delivering an isolated polynucleotide such as DNA or RNA, to the interior of a cell in a mammal comprising the injection of an isolated polynucleotide into a muscle of the mammal where the polynucleotide is taken up by the cells of the muscle and exerts a therapeutic effect on the mamma ...


3
James A Thomson: Primate embryonic stem cells. Wisconsin Alumni Research Foundation, Quarles & Brady, December 1, 1998: US05843780 (363 worldwide citation)

A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (-); SSEA-3 (+); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); and alkaline phosphatase (+). In a particularly advantageous embodiment, the cells of the prep ...


4
Thomas A Duff: Vertebral clamp. Wisconsin Alumni Research Foundation, David J Houser, September 16, 1986: US04611582 (355 worldwide citation)

A vertebral clamp adapted to control the spatial relationship between two vertebrae by attachment to the laminae thereof. The vertebral clamp includes a longitudinally extending body divided into first and second halves. The halves are fastened together by fastening means that allow for adjustment o ...


5
Stuart J Updike, Mark C Shults: Method for monitoring blood glucose levels and elements. Wisconsin Alumni Research Foundation, McDougall Hersh & Scott, December 23, 1980: US04240438 (340 worldwide citation)

A method for monitoring blood glucose levels at frequent intervals, which includes a method for equalizing the temperature and oxygen level in the blood and sensing the rate of oxygen consumption by the glucose contained in the blood in the presence of glucose oxidase enzyme immobilized on a hydroph ...


6
James A Thomson: Primate embryonic stem cells. Wisconsin Alumni Research Foundation, Quarles & Brady, March 13, 2001: US06200806 (295 worldwide citation)

A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); and alkaline phosphatase (+). In a particularly advantageous embodiment, the cells of ...


7
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Generation of antibodies through lipid mediated DNA delivery. Wisconsin Alumni Research Foundation, Vical Incorporated, Knobbe Martens Olson & Bear, December 30, 1997: US05703055 (246 worldwide citation)

A method is disclosed for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic e ...


8
Malcolm J Williamson, Kenneth L Cummins, Kurt E Hecox: Adaptive, programmable signal processing and filtering for hearing aids. Wisconsin Alumni Research Foundation, Foley & Lardner, June 25, 1991: US05027410 (208 worldwide citation)

A hearing aid system utilizes digital signal processing to correct for the hearing deficit of a particular user and to maximize the intelligibility of the desired audio signal relative to noise. An analog signal from a microphone is converted to digital data which is operated on by a digital signal ...


9
Charles M Strother, Balakrishna V Kudva: Detachable balloon catheter. Wisconsin Alumni Research Foundation, Isaksen Lathrop Esch Hart & Clark, December 21, 1982: US04364392 (197 worldwide citation)

A method and apparatus is disclosed for providing therapeutic occlusions of blood vessels and other body tubular structures using an inflatable balloon (11) mounted at the end of a catheter (15). The balloon (11) and catheter (15) are passed through a blood vessel (12) until the balloon (15) reaches ...


10
John R Conrad: Method and apparatus for plasma source ion implantation. Wisconsin Alumni Research Foundation, Isaksen Lathrop Esch Hart & Clark, August 16, 1988: US04764394 (191 worldwide citation)

Ion implantation into surfaces of three-dimensional targets is achieved by forming an ionized plasma about the target within an enclosing chamber and applying a pulse of high voltage between the target and the conductive walls of the chamber. Ions from the plasma are driven into the target object su ...



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