1
Deluca Hector F, Schnoes Heinrich K, Perlman Kato L, Sicinski Rafal R, Prahl Jean Martin: 19-nor vitamin d compounds.. Wisconsin Alumni Res Found, September 12, 1990: EP0387077-A1 (79 worldwide citation)

This invention provides a novel class of vitamin D-related compounds, namely the 1 alpha -hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignan ...


2
Felgner Philip L, Wolff Jon Asher, Rhodes Gary H, Malone Robert Wallace, Carson Dennis A: Expression of exogenous polynucleotide sequences in a vertebrate. Vical, Wisconsin Alumni Res Found, October 16, 1996: EP0737750-A2 (68 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...


3
Aranyi Ernest, Cuny Douglas J, Heinrich Russell, Lal Amit, Lewis Bill, Roy Phil: Ultrasonic surgical instrument. Tyco Healthcare, Wisconsin Alumni Res Found, July 14, 2004: EP1435852-A1 (62 worldwide citation)

An ultrasonic surgical instrument is provided which includes a handle assembly (218), a body (220) extending distally form the handle assembly and an end effector (222) configured to effect cutting, dissection, coagulation and/or ligation of tissue. The end effector (222) includes an ultrasonic memb ...


4
Deluca Hector Floyd, Schnoes Heinrich Konstantine, Perlman Kato Leonard, Swenson Rolf E: Novel synthesis of 19-nor vitamin d compounds.. Wisconsin Alumni Res Found, December 2, 1992: EP0516410-A2 (50 worldwide citation)

A convergent synthesis of 19-nor-vitamin D compounds, specifically 19-nor-1 alpha ,25-dihydroxyvitamin D3, is disclosed. The synthesis can also readily be utilized for preparing other 1 alpha -hydroxylated 19-nor-vitamin D compounds. The key step in the synthesis is a suitable application of Lythgoe ...


5
Guckel Henry, Sniegowski Jeffrey J: Polysilicon resonating beam transducers and method of producing the same.. Wisconsin Alumni Res Found, October 16, 1991: EP0451992-A2 (42 worldwide citation)

Force transducers are formed of a beam of polysilicon which is mounted at its ends to a silicon substrate and is encapsulated within a polysilicon shell which defines, with the substrate, a cavity around the resonating beam. The cavity is sealed off from the atmosphere and evacuated to maximize the ...


6
Felgner Philip L, Wolff Jon Asher, Rhodes Gary H, Malone Robert Wallace, Carson Dennis A: Expression of exogenous polynucleotide sequences in a vertebrate. Vical, Wisconsin Alumni Res Found, August 9, 2000: EP1026253-A2 (36 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...


7
Deluca Hector Floyd: Novel use of 1alpha-hydroxylated-19-nor-vitamin d compounds to treat psoriasis.. Wisconsin Alumni Res Found, March 11, 1992: EP0474517-A2 (33 worldwide citation)

A novel use for 1 alpha -hydroxylated-19-nor-vitamin D compounds to treat psoriasis inasmuch as these compounds when administered to humans are converted to a metabolite, such as a 1 alpha ,25-dihydroxylated compound, which metabolite in vitro will cause differentiation in a human cell line.


8
Deluca Hector Floyd, Smith Connie Marie: Methods and compositions containing vitamin d compounds for improvements of skin conditions.. Wisconsin Alumni Res Found, April 15, 1992: EP0480572-A1 (28 worldwide citation)

Compositions containing vitamin D compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, lack of dermal hydration and insufficient sebum secretion. Various f ...


9
Temin Howard M, Boris Lawrie Kathleen A: More complex type retroviruses having mixed type ltr, and uses thereof.. Wisconsin Alumni Res Found, August 24, 1994: EP0611822-A2 (26 worldwide citation)

A recombinant retrovirus comprising an RNA sequence having simpler (S) Type retroviral long termini; a more complex (MC) Type att, pbs, E and ppt RNA sequence; and an RNA sequence encoding an MC Type retroviral protein selected from human immunodeficiency virus proteins, human spumaretrovirus protei ...


10
Sih Charles J: Process for preparing (s)-alpha-methylarylacetic acids.. Wisconsin Alumni Res Found, July 1, 1987: EP0227078-A1 (21 worldwide citation)

The invention relates to a process for preparing (S)-alpha-methylarylacetic acids from mixtures, such as racemic mixtures, of (R)- and (S)-alpha-methylarylacetic acid esters by enantiospecific hydrolysis using extracellular lipases of microbial origin (EC 3.1.1.3). Preferably S-2-(6-methoxy-2-naphth ...