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Van T, Klooster Gerben Albert Eleutherius, Wigerinck Piet Tom Bert Paul, de, Meyer Sandra, Baert Lieven Elvire Colette, de, Kock Herman Augustinus: Use of a sulfonamide compound for improving the pharmacokinetics of a drug. Tibotec Pharmaceuticals, Van T, Klooster Gerben Albert Eleutherius, Wigerinck Piet Tom Bert Paul, de, Meyer Sandra, Baert Lieven Elvire Colette, de, Kock Herman Augustinus, DAELEMANS Frank, October 19, 2006: WO/2006/108879 (10 worldwide citation)

A method for improving the pharmacokinetics of drugs, which are metabolized by cytochrome P450 monooxygenase is disclosed. More specifically it relates to a method for improving the pharmacokinetics of retroviral protease inhibitors and in particular for improving the pharmacokinetics of human immun ...


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Goyvaerts Nicolaas Martha Felix, Wigerinck Piet Tom Bert Paul, Zinser Hartmut Burghard, Ebert Birgit M: (isobutyl) Amino]-1-benzyl-2-hydroxypropylcarbamate. Tibotec Pharmaceuticals, Goyvaerts Nicolaas Martha Felix, Wigerinck Piet Tom Bert Paul, Zinser Hartmut Burghard, Ebert Birgit M, DAELEMANS Frank, July 14, 2005: WO/2005/063770 (8 worldwide citation)

The present invention relates to a process for the preparation of (3R,3aS,6aR)­-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate as well as intermediates for use in said process. More in particular the invention relates to pro ...


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De, Kock Herman Augustinus, Wigerinck Piet Tom Bert Paul, Balzarini Jan: Hiv prodrugs cleavable by cd26. Tibotec, Pharmaceuticals, de, Kock Herman Augustinus, Wigerinck Piet Tom Bert Paul, Balzarini Jan, DAELEMANS Frank, November 18, 2004: WO/2004/099135 (7 worldwide citation)

The present invention provides new prodrugs which are conjugates of a therapeutic compound and a peptide wherein the conjugate is cleavable by dipeptidyl-peptidases, more preferably by CD26, also known as DPPIV (dipeptidyl aminodipeptidase IV). The present prodrugs have the formula (I), the stereois ...


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Surleraux Dominique Louis Nestor Ghislain, Wigerinck Piet Tom Bert Paul, Getman Daniel P: Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors. Tibotec Pharmaceuticals, Surleraux Dominique Louis Nestor Ghislain, Wigerinck Piet Tom Bert Paul, Getman Daniel P, DAELEMANS Frank, February 19, 2004: WO/2004/014371 (7 worldwide citation)

The present invention relates to the use of 2-amino-benzothiazoles, having the formula (I) wherein R1 is hexahydrofuro[2,3-b]furanyl, tetrahydrofuranyl, oxazolyl, thiazolyl, pyridinyl, or phenyl optionally substituted with one or more substituents independently selected from C1-6-alkyl, hydroxy, ami ...


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Van, Acker Koenraad Lodewijk August, Wigerinck Piet Tom Bert Paul, Michiels Lieve Emma Jan, Tahri Abdellah: Entry inhibitors of the hiv virus. Tibotec Pharmaceuticals, Van, Acker Koenraad Lodewijk August, Wigerinck Piet Tom Bert Paul, Michiels Lieve Emma Jan, Tahri Abdellah, DAELEMANS Frank, March 17, 2005: WO/2005/023242 (6 worldwide citation)

The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors ...


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Tahri Abdellah, Wigerinck Piet Tom Bert Paul: Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors. Tibotec Pharmaceuticals, Tahri Abdellah, Wigerinck Piet Tom Bert Paul, DAELEMANS Frank, February 26, 2004: WO/2004/016619 (5 worldwide citation)

The present invention concerns the compounds having the formula (I) N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C 1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radi ...


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De, Kock Herman Augustinus, Jonckers Tim Hugo Maria, Last Stefaan Julien, Boonants Paul Jozef Gabriel Maria, Surleraux Dominique Louis Nestor Ghislain, Wigerinck Piet Tom Bert Paul: Substituted aminophenylsulfonamide compounds as hiv protease inhibitor. Tibotec Pharmaceuticals, de, Kock Herman Augustinus, Jonckers Tim Hugo Maria, Last Stefaan Julien, Boonants Paul Jozef Gabriel Maria, Surleraux Dominique Louis Nestor Ghislain, Wigerinck Piet Tom Bert Paul, DAELEMANS Frank, May 31, 2007: WO/2007/060253 (4 worldwide citation)

The present invention concerns substituted aminophenylsulfonamide compounds, their use as protease inhibitors, in particular as broad-spectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention al ...