1
Welsh William J, Yu Seong Jae, Nair Anil: Opiate analogs selective for the delta-opioid receptor. The Curators Of The University Of Missouri, Welsh William J, Yu Seong Jae, Nair Anil, HIGHLANDER Steven L, April 1, 2004: WO/2004/026819 (12 worldwide citation)

Novel compounds which selectively bind to the &dgr;-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the &dgr;-opioid receptor have shown promise in pro ...


2
Welsh William J, Peng Youyi, Wang Xin, Keenan Susan M, Zhang Quiang, Arora Sonia: Anti-mitotic anti-proliferative compounds. University Of Medicine And Dentistry Of New Jersey, Welsh William J, Peng Youyi, Wang Xin, Keenan Susan M, Zhang Quiang, Arora Sonia, KLOSEK Sarah, May 4, 2006: WO/2006/047631 (11 worldwide citation)

Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.


3
Welsh William J, Peng Youyi, Zhang Qiang, Keenan Susan M, Arora Sonia: Opioid receptor subtype-selective agents. University Of Medicine And Dentistry Of New Jersey, Welsh William J, Peng Youyi, Zhang Qiang, Keenan Susan M, Arora Sonia, KLOSEK Sarah, November 23, 2006: WO/2006/124687 (9 worldwide citation)

Opioid receptor compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a condition mediated by an opioid receptor by administering an effective amount of the opioid receptor compound to a patient in need thereof.


4
Welsh William J, Arora Sonia, Yang Kaipeen: Lipophilic opioid receptor active compounds. University Of Medicine And Dentistry Of New Jersey, Welsh William J, Arora Sonia, Yang Kaipeen, MLYNEK Peter D, May 29, 2008: WO/2008/064317 (5 worldwide citation)

Substituted pyrazoles, imidazoles, triazoles, other 5-membered heteroaromatic ring compounds, substituted 6-membered heteroaromatic ring compounds, and fluorene and carbazole compounds, may be included in pharmaceutical central nervous system drug compositions to treat a condition mediated by an opi ...


5
Welsh William J, Keenan Susan M, Delisle Robert K, Ball William J: Novel pharmacophore for the discovery and testing of na, k-atpase inhibitor compositions and methods for their use in treating cardiovascular diseases and conditions. University Of Medicine And Dentistry Of New Jersey, Welsh William J, Keenan Susan M, Delisle Robert K, Ball William J, LICATA Jane Massey, May 27, 2004: WO/2004/043384 (4 worldwide citation)

Disclosed is a novel pharmacophore and novel inotropic compositions created from the novel pharmacophore. Also disclosed are methods of making and using the novel pharmacophore and method of use of novel compositions to treat heart diseases by inhibiting Na, K-ATPase.


6
Welsh William J, Arora Sonia, Yang Kaipeen: Peripheral opioid receptor active compounds. University Of Medicine And Dentistry Of New Jersey, Welsh William J, Arora Sonia, Yang Kaipeen, MLYNEK Peter D, May 29, 2008: WO/2008/064318 (4 worldwide citation)

Substituted pyrazoles, imidazoles, triazoles, other 5-membered heteroaromatic ring compounds, substituted 6-membered heteroaromatic ring compounds, fluorene and carbazole compounds, and pyrazoles, imidazoles, triazoles, and other 5- membered heteroaromatic ring compounds substituted with two phenyl ...


7

8
Welsh William J, Arora Sonia, Yang Kaipeen: Mixed opioid receptor active compounds. University Of Medicine And Dentistry Of New Jersey, Welsh William J, Arora Sonia, Yang Kaipeen, MLYNEK Peter D, May 29, 2008: WO/2008/064310 (2 worldwide citation)

Pyrazoles, imidazoles, triazoles, other 5-membered heteroaromatic ring compounds substituted with two phenyl groups, and like compounds, may be included in pharmaceutical compositions to treat a condition mediated by an opioid receptor in a patient. The compounds possess a high binding affinity and ...


9
Welsh William J, Yu Seong Jae, Nair Anil: Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds. Univ Missouri, Welsh William J, Yu Seong Jae, Nair Anil, December 15, 2004: EP1485088-A1

The invention provides compounds of formula I: wherein R1to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of for ...


10
Welsh William J, Ouyang Ming, Lioy Paul, Georgopoulos Panos: Systems and methods for microarray data analysis. University Of Medicine And Dentistry Of New Jersey, Welsh William J, Ouyang Ming, Lioy Paul, Georgopoulos Panos, LICATA Jane Massey, February 10, 2005: WO/2005/013077

Clustering is routinely applied in the exploratory analysis of microarray data. Missing entries arise from blemishes on the microarrays. The present invention provides a new method, and computer program and/or computer product thereof to impute missing values. The method involves the steps of cluste ...