1
Keen Michael John, Rapson Nicholas Timothy: Culture medium for cho-cells and adapted cho-cells.. Wellcome Found, April 22, 1992: EP0481791-A2 (144 worldwide citation)

A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, comprising water, an osmolality regulator, a buffer, an energy source, amino acids including L-glutam ...


2
Huber Brian, Richards Cynthia Ann, Krenitsky Thomas Anthony: Novel entities for cancer therapy.. Wellcome Found, March 6, 1991: EP0415731-A2 (103 worldwide citation)

Novel molecular chimaeras produced by recombinant DNA techniques are described. They comprise a target tissue specific transcriptional regulatory sequence (TRS) linked and controlling the expression of a heterologous enzyme for example Varicella Zoster Virus Thymidine Kinase (VZV TK) gene. A molecul ...


3
Koszalka George Walter, Krenitsky Thomas Anthony: Therapeutic nucleosides and their preparation.. Wellcome Found, December 30, 1986: EP0206497-A2 (101 worldwide citation)

The present invention relates to certain 2 min ,3 min -dideoxynucleosides and pharmaceutically acceptable derivatives thereof, methods for preparing them, their use in the treatment and prophylaxis of viral, especially retroviral, infections, and pharmaceutical formulations containing them.


4
Rideout Janet Litster, Barry David Walter, Lehrman Sandra Nusinoff, St Clair Martha Heider, Furman Phillip Allen, Freeman George Andrew, Zimmerman Thomas Paul, Wolberg Gerald, de Miranda Paulo M, Shaver Sammy Ray, White Geoffrey, Kirk Iii Leone Edward, King Dannie Hilleary, Clemons Richard Harlon: Therapeutic nucleosides.. Wellcome Found, April 8, 1987: EP0217580-A2 (94 worldwide citation)

The present invention relates to certain novel 3 min -azidonucleosides and pharmaceutically acceptable derivatives thereof; the use of certain 3 min -azidonucleosides, their pharmaceutically acceptable derivatives and therapeutic combinations containing them, in therapy, particularly in the treatmen ...


5
Kneen Geoffrey, Jackson William Paul, Islip Peter John, Wates Peter John: Aryl derivatives.. Wellcome Found, October 1, 1986: EP0196184-A2 (72 worldwide citation)

Novel compounds of formula (I) Ar-(L-Ar') q-(X) k-(Y) p-Q (I) wherein:- k,p and q are independently 0 or 1, provided that when k is 1 then p must also be 1; Ar represents either: (i) naphthyl, tetrahydronaphthyl or pyridyl, any of which is optionally substituted by one or more substituents independe ...


6
Beauchamp Lilia Marie: Antiviral pyrimidine and purine compounds, process for their preparation and pharmaceutical compositions containing them.. Wellcome Found, June 27, 1990: EP0375329-A2 (69 worldwide citation)

The present invention relates to amino acid esters of pyrimidine and purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment and prophylaxis of herpes virus infections. Also provided are pharmaceutical formulations and processes for the prepa ...


7
Daluge Susan Mary: Therapeutic nucleosides.. Wellcome Found, June 26, 1991: EP0434450-A2 (64 worldwide citation)

The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. The invention also relates to pharmaceutical formulations and processes for the preparation of compounds according to the invention.


8
Robertson Alan Duncan, Martin Graeme Richard, Buckingham Janet Susan: Therapeutic heterocyclic compounds.. Wellcome Found, April 26, 1989: EP0313397-A1 (63 worldwide citation)

The present invention is concerned with compounds of formula (I) wherein R, R and R are independently selected from hydrogen and C1-4 alkyl; R and R are independently selected from hydrogen, C1-6 alkyl (including cycloalkyl) and aryl (wherein the alkyl or aryl group, which latter includes benzyl, is ...


9
Daluge Susan Mary: Therapeutic nucleosides.. Wellcome Found, January 3, 1990: EP0349242-A2 (58 worldwide citation)

The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment and prophylaxis of HIV and HBV infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invent ...


10
Crowe James Scott, Lewis Alan Peter: Production of antibodies.. Wellcome Found, January 20, 1993: EP0523949-A1 (54 worldwide citation)

This invention relates to the preparation of recombinant primate antibodies by DNA technology; Micro-RNA techniques for production of the same; recombinant non-human primate antibodies; formulations containing the same; the use of such antibodies in the prophylaxis and treatment of humans, and diagn ...