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Clark Richard, Hirota Shinsuke, Azuma Hiroshi, Kira Kazunobu, Watanabe Nobuhisa, Nagakura Tadashi, Horizoe Tatsuo: (Ja) ヒドラジド誘導体, (En) Hydrazide derivatives. Eisai R & D Management, Clark Richard, Hirota Shinsuke, Azuma Hiroshi, Kira Kazunobu, Watanabe Nobuhisa, Nagakura Tadashi, Horizoe Tatsuo, HASEGAWA Yoshiki, April 20, 2006: WO/2006/041119 (24 worldwide citation)

(EN) Compounds represented by the general formula (1) or salts thereof, or hydrates of both, which are safe and have moderate physicochemical stability and which are useful as preventive or therapeutic agents for diseases caused by thrombus formation wherein R1a, R1b, R1c and R1d are each independen ...


2
YOSHIDA Ichiro, OKABE Tadashi, MATSUMOTO Yasunobu, WATANABE Nobuhisa, OHASHI Yoshiaki, ONIZAWA Yuji, HARADA Hitoshi: [ja] ピロリジン-3-イル酢酸誘導体, [fr] DÉRIVÉ DE LACIDE PYRROLIDIN-3-YLACÉTIQUE, [en] PYRROLIDINE-3-YLACETIC ACID DERIVATIVE. YOSHIDA Ichiro, OKABE Tadashi, MATSUMOTO Yasunobu, WATANABE Nobuhisa, OHASHI Yoshiaki, ONIZAWA Yuji, HARADA Hitoshi, Eisai R&D Management, HASEGAWA Yoshiki, March 21, 2013: WO/2013/039057 (1 worldwide citation)

[en] A compound indicated by formula (1) or a pharmaceutically acceptable salt thereof, having an inhibitory activity in a fractalkine-CX3CR1 pathway. [R indicates a C1-6 alkyl group having 1-3 unsubstituted groups or 1-3 substituted groups selected from a group (A) of substituted groups, a C3-8 cyc ...


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Tanaka Isao, Watanabe Nobuhisa, Takeuchi Hiroshi, Iseki Takayuki, Shibuya Nozomu, Nishijima Chiharu: (Ja) 蛋白質結晶化装置、蛋白質結晶化方法、蛋白質結晶化剤、及びその調製方法, (En) Protein crystallization apparatus, method of protein crystallization, protein crystallizing agent and process for preparing the same. Mitsubishi Rayon, Tanaka Isao, Watanabe Nobuhisa, Takeuchi Hiroshi, Iseki Takayuki, Shibuya Nozomu, Nishijima Chiharu, SHIGA Masatake, February 17, 2005: WO/2005/014899

(EN) A protein crystallization apparatus with which protein crystallization experiments and crystallization condition screening can be carried out rapidly and economically with high reliability; and a protein crystallizing agent with which the operation of protein crystallization can be carried out ...


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Miyazawa Shuhei, Harada Hitoshi, Fujisaki Hideaki, Kubota Atsuhiko, Kodama Kotaro, Nagakawa Junichi, Watanabe Nobuhisa, Oketani Kiyoshi: Imidazopyridine compound. Eisai R & D Management, Miyazawa Shuhei, Harada Hitoshi, Fujisaki Hideaki, Kubota Atsuhiko, Kodama Kotaro, Nagakawa Junichi, Watanabe Nobuhisa, Oketani Kiyoshi, ASAMURA Kiyoshi, November 3, 2005: WO/2005/103049

A compound represented by the following general formula (1), or a salt or hydrate thereof: wherein R1 represents a C1-C6 alkyl group or C2-C6 alkynyl group which may be substituted, or a phenyl group which may be substituted, R2 represents a hydrogen atom or a C1-C6 alkyl group, R3 represents methyl ...


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Kuwabara Yasuo, Ota Hiroshige, Matsuoka Akira, Hayashi Takumi, Watanabe Nobuhisa: Hydrogen generator. Aisin Seiki Kabushiki Kaisha, Kuwabara Yasuo, Ota Hiroshige, Matsuoka Akira, Hayashi Takumi, Watanabe Nobuhisa, KUWABARA Hideaki, September 6, 1996: WO/1996/026892

A hydrogen generator provided with a housing (10) containing a catalyst (11) filled in an inner space (10a), a supply pipe (12) opening in the space (10a), a blowout pipe (14) for blowing out a reformed gas generated by the reaction in the space (10a) therefrom, methanol supply means (20, 21) connec ...


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Watanabe Nobuhisa, Kabasawa Yasuhiro, Takase Yasutaka, Ozaki Fumihiro, Ishibashi Keiji, Miyazaki Kazuki, Matsukura Masayuki, Souda Shigeru, Miyake Kazutoshi, Ishihara Hiroki, Kodama Kohtaro, Adachi Hideyuki: Fused pyridazine compound. Eisai, Watanabe Nobuhisa, Kabasawa Yasuhiro, Takase Yasutaka, Ozaki Fumihiro, Ishibashi Keiji, Miyazaki Kazuki, Matsukura Masayuki, Souda Shigeru, Miyake Kazutoshi, Ishihara Hiroki, Kodama Kohtaro, Adachi Hideyuki, FURUYA Kaoru, February 22, 1996: WO/1996/005176

A fused pyridazine compound represented by general formula (I) and having the inhibitory effect against cyclic GMP-phosphodiesterase (cGMP-PDE), and a pharmacologically acceptable salt thereof. These compounds are useful as preventives and remedies for diseases against which the cGMP-PDE inhibitory ...


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Minamitani Shozo, Mae Takaharu, Ueno Yasuharu, Yamada Akira, Kanayama Shinji, Akita Makoto, Watanabe Nobuhisa, Mori Akira, Naito Hiroyuki, Marumo Shinya, Morikawa Makoto: Electronic component mounting method and apparatus and ultrasondic bonding head. Matsushita Electric Industrial, Minamitani Shozo, Mae Takaharu, Ueno Yasuharu, Yamada Akira, Kanayama Shinji, Akita Makoto, Watanabe Nobuhisa, Mori Akira, Naito Hiroyuki, Marumo Shinya, Morikawa Makoto, sISHIHARA Masaru, October 2, 2003: WO/2003/081644

A component mounting apparatus includes a component feeder (20) that feeds a component (2) with its bump electrodes facing down, a mounting head (5) that mounts the component onto a substrate (3), a supporting base (8) that secures the substrate, and a positioning device (6, 7) that aligns the compo ...


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Tanaka Isao, Watanabe Nobuhisa, Takeuchi Hiroshi, Akita Takashi, Nagata Yuichirou, Sumi Toshinori, Nishijima Chiharu: Array for crystallizing protein, device for crystallizing protein and method of screening protein crystallization using the same. Mitsubishi Rayon, Tanaka Isao, Watanabe Nobuhisa, Takeuchi Hiroshi, Akita Takashi, Nagata Yuichirou, Sumi Toshinori, Nishijima Chiharu, HIRAKI Yusuke, July 3, 2003: WO/2003/053998

A method of precipitating protein crystals from a protein-containing sample; a novel microarray and a novel device for screening protein crystallization conditions; and a method of conveniently and quickly screening protein crystallization conditions from an ultramicro amount of a sample with the us ...


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Okada Toshimi, Kurusu Nobuyuki, Tanaka Keigo, Yoshikawa Seiji, Shinmyo Daisuke, Watanabe Nobuhisa, Ikuta Hironori, Hiyoshi Hironobu, Saeki Takao, Yanagimachi Mamoru, Ito Masashi: N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient. Eisai, Okada Toshimi, Kurusu Nobuyuki, Tanaka Keigo, Yoshikawa Seiji, Shinmyo Daisuke, Watanabe Nobuhisa, Ikuta Hironori, Hiyoshi Hironobu, Saeki Takao, Yanagimachi Mamoru, Ito Masashi, FURUYA Kaoru, October 3, 2002: WO/2002/076973

A compound having excellent squalene synthetase inhibitory activity. It is a compound (I) represented by the following general formula, a salt thereof, or a hydrate of either. (I) In the formula, R?1¿ means optionally substituted vinyl or an optionally substituted aromatic ring; n is an integer of 0 ...