1
Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to enhance processivity of telomerase. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114064 (52 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the preparation of a medicament for enhancing the processivity of a telomerase increasing the number of mitotic cycles and mitotic cell division.


2
Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to inhibit neoplasia. Institute Of Organic Chemistry And Biochemistry A Cademy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114065 (51 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the manufacture of a medicament for inhibiting an enzyme that causes neoplasia in an animal (e.g. a human) and enhancing the processivity of a telomerase.


3
Hocek Michal, Votruba Ivan, Hol&Yacute: Novel 6-phenylpurine 9-$g(b)-d-ribonucleosides with antineoplastic activity, their use for preparing pharmaceutical compositions and pharmaceutical preparations containing such compounds. Ústav Organické Chemie A Biochemie, Akademie V&Ecaron, Hocek Michal, Votruba Ivan, Hol&Yacute, GABRIELOVÁ Marta, December 14, 2000: WO/2000/075158

Novel 6-phenylpurine 9-$g(b)-D-ribonucleosides with antineoplastic activity of general formula (I), wherein R?1¿ is H, methyl, fluoro, chloro or alkoxy (C1-C2) group, R?2¿ is H, methyl or fluoro group, and R?3¿ is H, fluoro or methoxy group. Pharmaceutical compositions containing the compounds of th ...


4
Holy Antonin, Otmar Miroslav, Piskala Alois, Votruba Ivan, Kovarik Ales, Fojtova Miloslava, Bartova Eva: 1-(2-deoxy-alpha-d-erythro-pentofuranosyl)-5-azacytosine for use as drug. Ustav Organicke Chemie A Biochemie Av Cr Vvi, Holy Antonin, Otmar Miroslav, Piskala Alois, Votruba Ivan, Kovarik Ales, Fojtova Miloslava, Bartova Eva, GABRIELOVA Marta, July 17, 2008: WO/2008/083634

The invention relates to 1-(2-deoxy-alpha-D-erythro-pentofuranosyl)-5-azacytosine of formula (I) for use as a hypomethylating drug applicable for epigenetic therapy of cancer and other epigenetically determined diseases and further includes the use of the compound of formula (I) for manufacturing of ...


5
Cerovsky Václav, Slaninová Jirina, Hovorka Oldrich, Cvacka Josef, Voburka Zdenek, Fucík Vladimír, Bednárová Lucie, Votruba Ivan, Borovicková Lenka, Turánek Jaroslav: Novel antimicrobial peptides and their application. Ustav Organicke Chemie A Biochemie Akademie Ved Ceske Republiky Vvi, Cerovsky Václav, Slaninová Jirina, Hovorka Oldrich, Cvacka Josef, Voburka Zdenek, Fucík Vladimír, Bednárová Lucie, Votruba Ivan, Borovicková Lenka, Turánek Jaroslav, HERMAN Václav, September 11, 2009: WO/2009/109156

This invention involves four novel peptides of the formulas I, II, III a IV isolated from natural sources and their synthetic analogs of general formula V and VI, where R1 represents acyl, alkyl or unprotected amino group, R2 represents amid, substituted amid, unprotected carboxylic group or ester, ...



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