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Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Parker Matthew A, Howard Stephen J, Santhapuram Hari Krishna, Satyam Apparao, Reddy Joseph Anand: Vitamin receptor binding drug delivery conjugates. Endocyte, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Parker Matthew A, Howard Stephen J, Santhapuram Hari Krishna, Satyam Apparao, Reddy Joseph Anand, BALL Rebecca L, August 19, 2004: WO/2004/069159 (52 worldwide citation)

The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety is a vitamin, or a vitamin receptor binding analog ...


2
Leamon Christopher Paul, Wang Yu, Vlahov Iontcho Radoslavov, You Fei, Kleindl Paul Joseph, Santhapuram Hari Krishna R: Conjugates containing hydrophilic spacer linkers. Endocyte, Leamon Christopher Paul, Wang Yu, Vlahov Iontcho Radoslavov, You Fei, Kleindl Paul Joseph, Santhapuram Hari Krishna R, BALL Rebecca L, December 31, 2008: WO/2009/002993 (38 worldwide citation)

Described herein are compositions and methods for use in targeted drug delivery using cell- surface receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations.


3
Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Satyam Apparao, Howard Stephen J: Bivalent linkers and conjugates thereof. Endocyte, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Satyam Apparao, Howard Stephen J, BALL Rebecca L, February 2, 2006: WO/2006/012527 (36 worldwide citation)

Bivalent linkers derived from compounds of formulae (V), (VI) and (VII), where X1 and X2 are leaving groups and the other variables are as defined in the claims, to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.


4
Xu Le Cun, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Santhapuram Hari Krishna, Li Chunhong: Synthesis and purification of pteroic acid and conjugates thereof. Endocyte, Xu Le Cun, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Santhapuram Hari Krishna, Li Chunhong, ADDISON Bradford G, September 28, 2006: WO/2006/101845 (32 worldwide citation)

Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also descri ...


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Lemaon Christopher Paul, Vlahov Iontcho Radoslavov: Ligand conjugates of vinca alkaloids, analogs, and derivatives. Endocyte, Lemaon Christopher Paul, Vlahov Iontcho Radoslavov, ADDISON Bradford G, February 22, 2007: WO/2007/022493 (29 worldwide citation)

Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of cytotoxic drugs and vitamin receptor binding ligands. The conjugates also include a linker that is formed from one or mo ...


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Vlahov Iontcho Radoslavov, Leamon Christopher Paul: Multi-drug ligand conjugates. Endocyte, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, ADDISON Bradford G, February 22, 2007: WO/2007/022494 (23 worldwide citation)

Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands. The plurality of drugs may be the same or different ...


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Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Wang Yu: Binding ligand linked drug delivery conjugates of tubulysins. Endocyte, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Wang Yu, BALL Rebecca L, September 18, 2008: WO/2008/112873 (19 worldwide citation)

Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include conjugates of tubulysins and vitamin receptor binding ligands. The conjugates also include a releasable bivalent linker.


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Low Philip Stewart, Varghese Bindu, Vlahov Iontcho Radoslavov: Positron emission tomography imaging method. Purdue Research Foundation, Endocyte, Low Philip Stewart, Varghese Bindu, Vlahov Iontcho Radoslavov, ADDISON Bradford, July 6, 2006: WO/2006/071754 (18 worldwide citation)

The invention relates to compositions and methods to diagnose/monitor, using positron emission tomography, pathogenic disease states wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. In an illustrative embodiment, vitamins, or analogs thereof, c ...


9
Vlahov Iontcho Radoslavov, Wang Yu, Leamon Christopher Paul: Tubulysins and processes for preparing. Endocyte, Vlahov Iontcho Radoslavov, Wang Yu, Leamon Christopher Paul, MCLAREN Kevin L, April 30, 2009: WO/2009/055562 (17 worldwide citation)

Processes are described for the preparation of tubulysins. The processes are useful for preparing predetermined mixtures of tubulysins, preparing single tubulysins from mixtures of tubulysins, and for converting one tubulysin into a different tubulysin. The tubulysins described herein are useful in ...


10
VLAHOV Iontcho Radoslavov, GROANING Michael, KLEINDL Paul Joseph, SANTHAPURAM Hari Krishna R, YOU Fei, WANG Yu, XU Le cun, STANFORD Katheryn Marie, RITTER Allen, LEAMON Christopher Paul: Procédés de préparation de tubulysines, Processes for preparing tubulysins. Endocyte, VLAHOV Iontcho Radoslavov, GROANING Michael, KLEINDL Paul Joseph, SANTHAPURAM Hari Krishna R, YOU Fei, WANG Yu, XU Le cun, STANFORD Katheryn Marie, RITTER Allen, LEAMON Christopher Paul, BALL Rebecca L, February 9, 2012: WO/2012/019123 (8 worldwide citation)

Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.