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Richard L Dunn, Arthur J Tipton, George L Southard, Jack A Rogers: Biodegradable system for regenerating the periodontium. Vipont Pharmaceutical, Merchant Gould Smith Edell Welter & Schmidt, December 31, 1991: US05077049 (144 worldwide citation)

Methods are described for assisting the restoration of periodontal tissue in a periodontal pocket and for retarding migration of epithelial cells along the root surface of a tooth. The methods involve placement of an in-situ forming biodegradable barrier adjacent the surface of a tooth. The barrier ...


2
Richard L Dunn, Arthur J Tipton, Ronald J Harkrader, Jack A Rogers: Intragingival delivery systems for treatment of periodontal disease. Vipont Pharmaceutical, Merchant Gould Smith Edell Welter & Schmidt, June 28, 1994: US05324520 (87 worldwide citation)

A polymeric controlled delivery system is provided for use in treating periodontal disease. The delivery system in a variety of forms is placed directly in the infected gingival tissue where the chemotherapeutic agent is slowly released into the tissue and into the infected periodontal pocket by mea ...


3
G Lee Southard, Ronald J Harkrader: Drug delivery devices. Vipont Pharmaceutical, Merchant Gould Smith Edell Welter & Schmidt, May 7, 1991: US05013553 (44 worldwide citation)

Drug delivery devices and techniques are described for use in treatment of periodontal disease and the like. The delivery device includes benzo (c) phenanthridine alkaloid in a bioerodable and biocompatible material. The alkaloid is slowly released from the bioerodable material in the oral cavity. T ...


4
Richard L Dunn, Kenneth C Godowski, Ronald J Harkrader, George L Southard: Muscosal delivery systems for treatment of periodontal disease. Vipont Pharmaceutical, Merchant Gould Smith Edell Welter & Schmidt, December 4, 1990: US04975271 (23 worldwide citation)

A muscosal delivery system is provided for use in treating periodontal disease. The system is composed of a chemotherapeutic agent dissolved in a skin-penetration enhancer. The solution of chemotherapeutic agent and skin-penetration enhancer is placed into the periodontal pocket where the agent is t ...


5
Richard T Boulware, George Schlowsky: Production of high purity alkaloids. Vipont Pharmaceutical, April 4, 1989: US04818533 (12 worldwide citation)

A method for extracting valuable alkaloid materials from plants containing the same comprising slurrying the comminuted plant material in a mixture of water and a cosolvent at a pH of 8.5, adding a nonpolar, water-insoluble, solvent to dissolve the alkaloid, washing the nonpolar phase with acidulate ...


6
Kenneth C Godowski, Ronald J Harkrader, Richard L Dunn, Arthur J Tipton: Free amine benzophenanthridine alkaloid compositions. Vipont Pharmaceutical, Merchant Gould Smith Edell Welter & Schmidt, December 29, 1992: US05175000 (11 worldwide citation)

A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.


7
Kenneth C Godowski, Ronald J Harkrader, Richard L Dunn, Arthur J Tipton: Free amine benzophenanthridine alkaloid compositions. Vipont Pharmaceutical, Merchant Gould Smith Edell Welter & Schmidt, March 7, 1995: US05395615 (7 worldwide citation)

A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.


8
Ronald J Harkrader, Richard R Jones, Kenneth S Peterson: Oral rinse compositions. Vipont Pharmaceutical, Dean P Edmundson, November 19, 1991: US05066483 (6 worldwide citation)

Mouthrinses containing sanguinarine of superior efficacy and increased uptake into dental plaque are attained by the development of stable mouthrinses adjusted to a pH in the range of 4.0 to 5.6, preferably about 4.5. The compositions may contain a zinc salt as an optional ingredient. Various types ...


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Sakamoto Seizaburo, Sugiyama Katsumi: Methode dinhibition de la liberation de lhistamine, Method for inhibiting the release of histamine. Vipont Pharmaceutical, Vipont Pharmaceutical, Sakamoto Seizaburo, Sugiyama Katsumi, Vipont Laboratories, SMART & BIGGAR, February 23, 1993: CA1313822

ABSTRACT The present invention deals with the inhibition ofhistamine release from mammalian mast cells by contactingsuch cells with sanguinarine, a benzophenanthridinealkaloid.