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De Veylder Lieven, Berx Geert, Takahashi Naoki, Quimbaya Mauricio, Raspé Eric: Minichromosome maintenance complex interacting protein involved in cancer. Vib Vzw, Universiteit Gent, de Veylder Lieven, Berx Geert, Takahashi Naoki, Quimbaya Mauricio, Raspé Eric, Vib Vzw, December 3, 2009: WO/2009/144311 (20 worldwide citation)

The present invention relates to a protein that is interacting with the minichromosome maintenance complex in eukaryotes. More specifically, the invention relates to the use of a protein, interacting with the minichromosome complex, and the gene encoding this protein in diagnosis, prognosis and trea ...


2
Bots Marc, Metzlaff Michael: Novel stress-related microrna molecules and uses thereof. Bayer Bioscience, Universiteit Gent, Vib Vzw, Bots Marc, Metzlaff Michael, BAYER BIOSCIENCE, November 22, 2007: WO/2007/131699 (17 worldwide citation)

Naturally occurring and synthetic novel stress-related miRNAs are provided which can be used to modify the stress tolerance of plants.


3
Carmeliet Peter: Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration. Vib Vzw, Life Sciences Research Partners Vzw, Carmeliet Peter, VIB VZW, July 26, 2007: WO/2007/082899 (17 worldwide citation)

The present invention relates to the field of muscle pathologies, more particularly to the field of diseases where skeletal muscle degeneration occurs. The invention describes transgenic mice which do not produce prolyl-hydroxylase-1, -2 or -3. It is revealed that the phenotype of the prolyl-hydroxy ...


4
Kas Koen, Vandekerckhove Joël, Krols Luc: Peptide combos and their uses. Vib Vzw, Universiteit Gent, Kas Koen, Vandekerckhove Joël, Krols Luc, VIB VZW, December 23, 2004: WO/2004/111636 (10 worldwide citation)

The invention provides reagents and methods for the accurate quantification of proteins in complex biological samples. Quantification is obtained by adding to a sample a peptide combo which is essentially a collection of synthetic reference peptides. Said synthetic reference peptides have a small ma ...


5
Hébert Sébastien, de, Strooper Bart: Oligonucleotide compositions for the treatment of alzheimers disease. Vib Vzw, Katholieke Universiteit Leuven Kuleuven R & D, Hébert Sébastien, de, Strooper Bart, VIB VZW, October 30, 2008: WO/2008/129023 (10 worldwide citation)

The invention relates to the identification of microRNAs which expression is diminished in neurodegenerative disorders. In particular, said identified microRNAs can be used for the downregulation of the beta-secretase (BACE1) in mammalian brain and hence for the treatment of Alzheimer's disease.


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Chuah Marinee, Vandendriessche Thierry, de Bleser Pieter: Liver-specific nucleic acid regulatory elements and methods and use thereof. Vib Vzw, Life Sciences Research Partners Vzw, Universiteit Gent, Chuah Marinee, Vandendriessche Thierry, de Bleser Pieter, VIB VZW, October 29, 2009: WO/2009/130208 (10 worldwide citation)

The present invention relates to nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed ...


7
Rousseau Frederic, Schymkowitz Joost, Da Rocha, Martins Ivo, de, Strooper Bart: Means and methods for the production of amyloid oligomers. Vib Vzw, Vrije Universiteit Brussel, Katholieke Universiteit Leuven Kuleuven R & D, Rousseau Frederic, Schymkowitz Joost, Da Rocha, Martins Ivo, de, Strooper Bart, VIB VZW, March 13, 2008: WO/2008/028939 (9 worldwide citation)

The present invention relates to the field of amyloid disorders, more particularly to the field of diseases where protein misfolding leads to the generation of insoluble amyloid fibers in tissues and organs. The invention provides methods for the production of soluble, toxic amyloid oligomers. The i ...


8
Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal: HAC1 nucleic acids, and. Oxyrane, VIB vzw, Universiteit Gent, Fish & Richardson P C, September 27, 2011: US08026083 (8 worldwide citation)

Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.


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PIENS Kathleen Camilla Telesphore Alida Maria, VERVECKEN Wouter: DÉMANNOSYLATION DES N-GLYCANES PHOSPHORYLÉS, DE-MANNOSYLATION OF PHOSPHORYLATED N-GLYCANS. OXYRANE, VIB VZW, UNIVERSITEIT GENT, PIENS Kathleen Camilla Telesphore Alida Maria, VERVECKEN Wouter, April 5, 2012: WO/2012/042387 (8 worldwide citation)

Methods for demannosylating phosphorylated N-glycans on a glycoprotein are described that use a mannosidase capable of hydrolyzing a terminal alpha-1,2 mannose linkage when the underlying mannose is phosphorylated.



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