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Lomonossoff George, Liu Li, Canizares Carmen, D Aoust Marc Andre, Vezina Louis Philippe: Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants. Plant Bioscience, Medicago, Lomonossoff George, Liu Li, Canizares Carmen, D Aoust Marc Andre, Vezina Louis Philippe, KREMER Simon, November 29, 2007: WO/2007/135480 (12 worldwide citation)

This invention comprises a combined transgene/virus vector system for the expression of heterologous proteins in plants. While exemplified with respect to the bipartite RNA plant virus, Cowpect mosaic virus (CPMV), other bipartite viral systems may be used to advantage according to the method, syste ...


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D Aoust Marc André, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie: (vlps) Comprising hemagglutinin produced within a plant. Medicago, D Aoust Marc André, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie, SECHLEY Konrad A, January 22, 2009: WO/2009/009876 (11 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...


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D Aoust Marc Andre, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie: Influenza virus-like particles (vlps) comprising hemagglutinin. Medicago, D Aoust Marc Andre, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie, Sechley Konrad A, January 14, 2010: WO/2010/003225 (7 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP ...


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D AOUST Marc Andre, COUTURE Manon, LAVOIE Pierre Olivier, VEZINA Louis Philippe: PRODUCTION DE PARTICULES DE TYPE VIRAL CHEZ DES VÉGÉTAUX, VIRUS LIKE PARTICLE PRODUCTION IN PLANTS. MEDICAGO, D AOUST Marc Andre, COUTURE Manon, LAVOIE Pierre Olivier, VEZINA Louis Philippe, SECHLEY Konrad A, June 28, 2012: WO/2012/083445 (3 worldwide citation)

A method of producing a virus like particle (VLP) in a plant, and compositions comprising VLPs, are provided. The method involves introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a chimeric nucleotide sequence encoding, in series, an ectodomain ...


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Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle: Soluble recombinant influenza antigens. Medicago, Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle, Sechley Konrad A, January 14, 2010: WO/2010/003235 (3 worldwide citation)

The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal ...


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D Aoust Marc Andre, Belles Isles Julie, Bechtold Nicole, Martel Michele, Lavoie Pierre Olivier, Vezina Louis Philippe: Protein production in plants. Medicago, D Aoust Marc Andre, Belles Isles Julie, Bechtold Nicole, Martel Michele, Lavoie Pierre Olivier, Vezina Louis Philippe, SECHLEY Konrad A, December 18, 2008: WO/2008/151444 (2 worldwide citation)

A method for synthesizing a protein of interest within a plant or a portion of a plant is provided. The method involves introducing one or more than one nucleic acid sequence encoding a protein of interest operatively linked with a regulatory region obtained from a photosynthetic gene that is active ...


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Vezina Louis Philippe, D Aoust Marc André, Arcand François, Bilodeau Pierre: Method of selecting plant promoters to control transgene expression. Medicago, Vezina Louis Philippe, D Aoust Marc André, Arcand François, Bilodeau Pierre, CAWTHORN Christian, May 10, 2002: WO/2002/036786

The present invention relates to a method for the identification and cloning of promoters that are useful in regulation of gene expression under different environmental conditions, such as in cultured transformed cells or in transgenic plants. A promoter that is a nucleic acid region located upstrea ...


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Paccalet Thomas, Bardor Muriel, Rihouey Christophe, Gomord Véronique, Faye Loïc, Lerouge Patrice, Aquin Stéphanie, Vezina Louis Philippe, D Aoust Marc André: Synthesis of sialic acid in plants. Medicago, Centre National de La Recherche Scientifique, Paccalet Thomas, Bardor Muriel, Rihouey Christophe, Gomord Véronique, Faye Loïc, Lerouge Patrice, Aquin Stéphanie, Vezina Louis Philippe, D Aoust Marc André, SECHLEY Konrad A, August 16, 2007: WO/2007/090290

A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N- ...