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Hu Zhihao, Valle Fernando: Enhanced production of fatty acid derivatives. Ls9, Hu Zhihao, Valle Fernando, SONG Victor L, October 2, 2008: WO/2008/119082 (78 worldwide citation)

Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.


2
Cervin Marguerite A, Soucaille Phillipe, Valle Fernando: Process for the biological production of 1,3-propanediol with high yield. Ei Du Pont de Nemours And Company, Genencor International, Cervin Marguerite A, Soucaille Phillipe, Valle Fernando, FLOYD Linda Axamethy, April 22, 2004: WO/2004/033646 (45 worldwide citation)

The present invention provides a microorganism useful for biologically producing 1,3-propanediol from a fermentable carbon source at higher yield than was previously known. The complexity of the cofactor requirements necessitates the use of a whole cell catalyst for an industrial process that utiliz ...


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Feher Frank J, Whited Gregory M, Chotani Gopal K, Valle Fernando, Fioresi Carol, Sanford Karl J, Mcauliffe Joseph C, Cervin Marguerite, Puhala Aaron S, Miasnikov Andrei, Aldor Illana S: Polymers of isoprene from renewable resources. The Goodyear Tire & Rubber Company, Genencor International, Feher Frank J, Whited Gregory M, Chotani Gopal K, Valle Fernando, Fioresi Carol, Sanford Karl J, Mcauliffe Joseph C, Cervin Marguerite, Puhala Aaron S, Miasnikov Andrei, Aldor Illana S, Rockhill Alvin T, January 14, 2010: WO/2010/005525 (19 worldwide citation)

It has been found that certain cells in culture can convert carbon available in the cell culture medium into isoprene These cells have a heterologous nucleic acid which is operably linked to a promoter and encodes an isoprene synthase polypeptide The isoprene produced in such a cultured medium can t ...


5
HAERIZADEH Farzad, VALLE Fernando, COTTAREL Guillaume: UTILISATION DUN PLASMIDE DE LEVURE DE 2 MICROMÈTRES ENDOGÈNE POUR LA SUREXPRESSION GÉNIQUE, USE OF AN ENDOGENOUS 2-MICRON YEAST PLASMID FOR GENE OVER EXPRESSION. CODEXIS, HAERIZADEH Farzad, VALLE Fernando, COTTAREL Guillaume, ONUFRYK Christina, April 5, 2012: WO/2012/044868 (3 worldwide citation)

Methods and compositions for making stable recombinant yeast 2 μm plasmids are provided. Homologous recombination is performed to clone a nucleic acid of interest into the yeast 2 μm plasmid. Heterologous nucleic acid subsequences are recombined between an FLP and a REP2 gene of the plasmid.


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Cervin Marguerite A, Soucaille Philippe, Valle Fernando, Whited Gregory M: Glucose transport mutants for production of biomaterial. Genencor International, Cervin Marguerite A, Soucaille Philippe, Valle Fernando, Whited Gregory M, STONE Christopher L, April 22, 2004: WO/2004/033471 (2 worldwide citation)

A method is disclosed for restoring a Glu+ phenotype to a PTS¯/Glu¯ bacterial cell which was originally capable of utilizing a phosphotransferase transport system (PTS) for carbohydrate transport. Bacterial cells comprising the Glu+ phenotype have modified endogenous chromosomal regulatory regions w ...


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Cervin Marguerite A, Soucaille Philippe, Trimbur Donald E, Valle Fernando: Improved production of bacterial strains. Genencor International, Cervin Marguerite A, Soucaille Philippe, Trimbur Donald E, Valle Fernando, STONE Christopher L, April 22, 2004: WO/2004/033421 (1 worldwide citation)

The present invention provides methods to enhance production of desired products and increase the growth rate of a bacterial strain by inactivating an endogenous arcA and optionally overexpressing a ppc gene.


8
Dodge Timothy C, Valle Fernando, Kumar Manoj, Rashid M Harunur: Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters. Genencor International, Dodge Timothy C, Valle Fernando, Kumar Manoj, Rashid M Harunur, STONE Christopher L, February 24, 2005: WO/2005/017099

The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancin ...


9
Dodge Timothy C, Valle Fernando, Rashid M Harunur: Metabolically engineered bacterial strains having enhanced 2-keto-d-gluconate accumulation. Genencor International, Dodge Timothy C, Valle Fernando, Rashid M Harunur, STONE Christopher L, February 10, 2005: WO/2005/012486

The present invention relates to a method of altering bacterial host cells to accumulate 2-keto-D-gluconic acid (2-KDG) by inactivating an endogenous membrane bound 2-keto-D-gluconate dehydrogenase (2-KDGDH), which prior to inactivation catalyzed the conversion of 2-KDG to 2,5-diketogluconate (2,5-D ...


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Caldwell Robert M, Rashid M Harunur, Valle Fernando: Multimeric oxidoreductases. Genencor International, Caldwell Robert M, Rashid M Harunur, Valle Fernando, STONE Christopher L, February 10, 2005: WO/2005/012547

The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and meth ...



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