1
Gary S Sayler, Michael L Simpson, Bruce M Applegate, Steven A Ripp: In vivo biosensor apparatus and method of use. UT Battelle, University of Tennessee Research Corporation, Akerman Senterfitt, January 6, 2004: US06673596 (333 worldwide citation)

Disclosed are bioluminescent bioreporter integrated circuit devices that detect selected analytes in fluids when implanted in the body of an animal. The device comprises a bioreporter that has been genetically engineered to contain a nucleic acid segment that comprises a cis-activating response elem ...


2
J Michael Ramsey, Stephen C Jacobson: Microfluidic devices for the controlled manipulation of small volumes. UT Battelle, Dann Dorfman Herrell and Skillman P C, February 25, 2003: US06524456 (242 worldwide citation)

A method for conducting a broad range of biochemical analyses or manipulations on a series of nano- to subnanoliter reaction volumes and an apparatus for carrying out the same are disclosed. The method and apparatus are implemented on a fluidic microchip to provide high serial throughput. The method ...


3
Stephen C Jacobson, J Michael Ramsey: Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same. UT Battelle, Dann Dorfman Herrell and Skillman P C, September 19, 2000: US06120666 (159 worldwide citation)

A microfabricated device and method for electrokinetic transport of a liquid phase biological or chemical material is described. In accordance with one aspect of the present invention there is provided a microchip that is adapted for the simultaneous spatial confinement of electrokinetically driven ...


4
Regina K Ferrell, Thomas P Karnowski, Kenneth W Tobin Jr: Method for indexing and retrieving manufacturing-specific digital imagery based on image content. UT Battelle, Akerman Senterfitt, June 15, 2004: US06751343 (136 worldwide citation)

A method for indexing and retrieving manufacturing-specific digital images based on image content comprises three steps. First, at least one feature vector can be extracted from a manufacturing-specific digital image stored in an image database. In particular, each extracted feature vector correspon ...


5
Milton N Ericson, Timothy E McKnight, Stephen F Smith, James O Hylton: Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring. UT Battelle, Gray Cary Ware & Friedenrich, March 18, 2003: US06533733 (122 worldwide citation)

The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by gen ...


6
Boyd McCutchen Evans III, Thomas G Thundat, Richard D Komistek, Douglas A Dennis, Mohamed Mahfouz: In-vivo orthopedic implant diagnostic device for sensing load, wear, and infection. UT Battelle, University of Tennessee Research Foundation, Kirk A Wilson, August 29, 2006: US07097662 (112 worldwide citation)

A device for providing in vivo diagnostics of loads, wear, and infection in orthopedic implants having at least one load sensor associated with the implant, at least one temperature sensor associated with the implant, at least one vibration sensor associated with the implant, and at least one signal ...


7
Tuan Vo Dinh: Advanced surface-enhanced Raman gene probe systems and methods thereof. UT Battelle, Shelley L Stafford, January 16, 2001: US06174677 (112 worldwide citation)

The subject invention is a series of methods and systems for using the Surface-Enhanced Raman (SER)-labeled Gene Probe for hybridization, detection and identification of SER-labeled hybridized target oligonucleotide material comprising the steps of immobilizing SER-labeled hybridized target oligonuc ...


8
Stephen F Smith: Short range spread-spectrum radiolocation system and method. UT Battelle, Gray Cary Ware & Freidenrich, April 29, 2003: US06556942 (110 worldwide citation)

A short range radiolocation system and associated methods that allow the location of an item, such as equipment, containers, pallets, vehicles, or personnel, within a defined area. A small, battery powered, self-contained tag is provided to an item to be located. The tag includes a spread-spectrum t ...


9
Stephen C Jacobson, J Michael Ramsey: Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream. UT Battelle, Dann Dorfman Herrell and Skillman P C, September 14, 2004: US06790328 (104 worldwide citation)

A microfluidic device for forming and/or dispensing minute volume segments of a material is described. In accordance with one aspect of the present invention, a microfluidic device and method is provided for spatially confining the material in a focusing element. The device is also capable of segmen ...


10
Stephen C Jacobson, J Michael Ramsey: Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs. UT Battelle, Dann Dorfman Herrell and Skillman P C, April 10, 2001: US06213151 (100 worldwide citation)

A microfabricated device and method for proportioning and mixing biological or chemical materials by pressure- or vacuum-driven flow is disclosed. The microfabricated device mixes a plurality of materials in volumetric proportions controlled by the flow resistances of tributary reagent channels thro ...