1
Marvin H Caruthers, Mark D Matteucci: Process for preparing polynucleotides. University Patents, George M Yahwak, July 3, 1984: US04458066 (892 worldwide citation)

New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).


2
Thomas R Cech, Arthur J Zaug, Michael D Been: RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods. University Patents, Fish & Richardson, January 22, 1991: US04987071 (515 worldwide citation)

RNA enzymes or ribozymes can act as endoribonucleases, catalyzing the cleavage of RNA molecules with a sequence specificity of cleavage greater than that of known ribonucleases and approaching that of the DNA restriction endonucleases, thus serving as RNA sequence specific endoribonucleases. An exam ...


3
Marvin H Caruthers, Serge L Beaucage: Phosphoramidite compounds and processes. University Patents, Scully Scott Murphy & Presser, November 15, 1983: US04415732 (424 worldwide citation)

A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.


4
Marvin H Caruthers, Mark D Matteucci: Nucleosides useful in the preparation of polynucleotides. University Patents, George M Yahwak, February 19, 1985: US04500707 (362 worldwide citation)

New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).


5
Klaus Brendel, Raymond C Duhamel: Body implants of extracellular matrix and means and methods of making and using such implants. University Patents, Barbara A Shimei, Stanley Sacks, January 31, 1989: US04801299 (315 worldwide citation)

A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such structures are implanted internally in the b ...


6
Ebtisam Wilkins: Membrane electrode for non-ionic species. University Patents, George M Yahwak, April 3, 1984: US04440175 (289 worldwide citation)

Concentrations of non-ionic species in aqueous media are measured as a function of potentiometric or polarographic response, employing a membrane electrode selective for the non-ionic species being measured. The electrode comprises a conductive substrate and a membrane formed as a layer on the condu ...


7
Marvin H Caruthers, William S Marshall, Wolfgang Brill, John Nielsen: Polynucleotide phosphorodithioate. University Patents, Yahwak & Associates, September 26, 1995: US05453496 (287 worldwide citation)

Oligonucleotides having at least one phosphorodithioate internucleotide linkage. Phosphorodithioate oligonucleotides exhibit stronger antiviral activity than the corresponding phoshorothioate derivatives.


8
Marvin H Caruthers, William S Marshall: Polynucleotide phosphorodithioates. University Patents, Yahwak & Associates, January 11, 1994: US05278302 (269 worldwide citation)

The present invention relates to novel oligonucleotides having phosphorodithioate internucleotide linkages which may be used for the treatment of diseases caused by viruses.


9
Marvin H Caruthers, Serge L Beaucage: Process for oligonucleo tide synthesis using phosphormidite intermediates. University Patents, Yahwak & Associates, November 27, 1990: US04973679 (253 worldwide citation)

A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.


10
Marvin H Caruthers, Serge L Beaucage: Phosphoramidite nucleoside compounds. University Patents, George M Yahwak, May 26, 1987: US04668777 (236 worldwide citation)

A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.