1
Andreas Plückthun, Lars Nieba, Annemarie Honegger: Immunoglobulin superfamily domains and fragments with increased solubility. University of Zurich, Heller Ehrman White and McAuliffe, November 9, 2004: US06815540 (30 worldwide citation)

The present invention relates to the modification of immunoglobulin superfamily (IgSF) domains, IgSF fragments and fusion proteins thereof, especially to the modification of antibody derivatives, so as to improve their solubility, and hence the yield, and ease of handling. The inventors have found t ...


2
Andreas Plückthun, Jozef Hanes, Lutz Jermutus: Polysome display in the absence of functional ssrA-RNA. University of Zurich, Heller Ehrman White and McAuliffe, July 8, 2003: US06589741 (15 worldwide citation)

The present invention relates to methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules. The method of the present invention is particularly characterized by an in vitro translation step under conditions that allow formation of polysomes in the pre ...


3
Donath Marc: Use of an interleukin 1 receptor antagonist and/or pyrrolidinedithiocarbamate for the treatment or prophylaxis of type 2 diabetes. University Of Zurich, Donath Marc, NOVO NORDISK, January 8, 2004: WO/2004/002512 (15 worldwide citation)

Substances that inhibit the action of the members of the IL-1 /NF- B pathway can be used for protecting and preserving -cell mass and function in prediabetic and diabetic type 2 patients. Specifically, the present invention relates to the use of an Interleukin 1 receptor antagonist (IL-1Ra) and/or p ...


4
Xandra O Breakefield, E Antonio Chiocca, Yoshinaga Saeki, Cornel Fraefel, Kurt Tobler, Mathias Ackermann, Mark Suter, Gosse J Adema, Ken Shortman: Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors. The General Hospital Corporation, University Medical Centre St Radboud of the University of Nijmegen, University of Zurich, The Walter & Eliza Hall Institute of Medical Research, Sterne Kessler Goldstein & Fox P L L C, June 3, 2003: US06573090 (13 worldwide citation)

The present invention relates to an enhanced and simplified herpes virus amplicon packaging system. The packaging system comprises a herpes virus amplicon vector and a packaging vector. In one embodiment, the packaging vector comprises a bacterial artificial chromosome (BAC) containing the HSV-1 gen ...


5
CHEN Feng, GRIMM Jan, BAERISWYL Jean Lue, NITSCH Roger, HOCK Christoph: ANTICORPS ANTI-TAU HUMAIN, HUMAN ANTI-TAU ANTIBODIES. PANIMA PHARMACEUTICALS, UNIVERSITY OF ZURICH, CHEN Feng, GRIMM Jan, BAERISWYL Jean Lue, NITSCH Roger, HOCK Christoph, April 19, 2012: WO/2012/049570 (13 worldwide citation)

Provided are human tau -specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain (s), as well as binding fragments, der ...


6
Motterlini Roberto Angelo, Alberto Roger Ariel: Use of boranocarbonates for the therapeutic delivery of carbon monoxide. Hemocorm, University Of Zurich, Motterlini Roberto Angelo, Alberto Roger Ariel, PAGET Hugh, February 17, 2005: WO/2005/013691 (11 worldwide citation)

Boranocarbonates are described for administration to a human or other mammal for delivery of carbon monoxide. The boranocarbonate is a compound or ion adapted to make CO available for physiological effect, and may be administered with a guanylate cyclase stimulant or stabilizer. The physiological ef ...


7
Nitsch Roger, Hock Christoph, Esslinger Christoph, Knobloch Marlen, Tissot Kathrin, Grimm Jan: Method of providing disease-specific binding molecules and targets. University Of Zurich, Nitsch Roger, Hock Christoph, Esslinger Christoph, Knobloch Marlen, Tissot Kathrin, Grimm Jan, July 10, 2008: WO/2008/081008 (11 worldwide citation)

Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/ ...


8
Heinrich Walt, Bärbel Selm, Thomas Wessel: Light-emitting textile structure, in particular for medical purposes, and use thereof. University of Zurich EMPA, Bolesh J Skutnik, BJ Associates, September 25, 2007: US07274844 (10 worldwide citation)

A light-emitting textile structure, which in particular is useful for medical purposes, comprises a flat support (2) and a plurality of light-emitting elements (4) fixed thereto. Each light-emitting element comprises a light-supplying optical fiber (6), to each optical fiber (6) there being associat ...


9
Michael Tobias Stumpp, Patrick Forrer, Hans Kaspar Binz, Andreas Plückthun: Collection of repeat proteins comprising repeat modules. University of Zurich, Arent Fox, August 26, 2008: US07417130 (10 worldwide citation)

The present invention relates to collections of repeat proteins comprising repeat modules which are derived from one or more repeat units of a family of naturally occurring repeat proteins, to collections of nucleic acid molecules encoding said repeat proteins, to methods for the constructions and a ...


10
John A Robinson, Daniel Obrecht: Synthesis of template-fixed β-hairpin loop mimetics. University of Zurich, Polyphor, Hoffmann & Baron, April 12, 2005: US06878804 (9 worldwide citation)

Template-fixed β-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 α-amino acid residues which, if their α-C atom is asymmetric, have L-configuration can be manufactured by a novel process w ...