1
Carl T Wittwer, Kirk M Ririe, Randy P Rasmussen: Monitoring amplification of DNA during PCR. University of Utah Research Foundation, Barnes & Thornburg, January 16, 2001: US06174670 (305 worldwide citation)

Methods of monitoring hybridization during polymerase chain reaction are disclosed. These methods are achieved with rapid thermal cycling and use of double stranded DNA dyes or specific hybridization probes. A fluorescence resonance energy transfer pair comprises fluorescein and Cy5 or Cy5.5. Method ...


2
Magdy F Iskander: Apparatus and method for time-domain tracking of high-speed chemical reactions. University of Utah Research Foundation, H Ross Workman, J Winslow Young, Allen R Jensen, August 2, 1983: US04396062 (288 worldwide citation)

A novel apparatus and method for time-domain tracking of high-speed chemical reactions. The apparatus of this invention includes a feedback system for controlling the RF frequency of an RF radiator system to thereby provide the optimum RF frequency for heating the reaction. The apparatus and method ...


3
Mario R Capecchi, Kirk R Thomas: Positive-negative selection methods and vectors. University of Utah Research Foundation, Townsend and Townsend Khourie and Crew, November 7, 1995: US05464764 (272 worldwide citation)

Positive-negative selector (PNS) vectors are provided for modifying a target DNA sequence contained in the genome of a target cell capable of homologous recombination. The vector comprises a first DNA sequence which contains at least one sequence portion which is substantially homologous to a portio ...


4
Thomas P Beebe, Carol E Rabke Clemmer: Thiol labeling of DNA for attachment to gold surfaces. University of Utah Research Foundation, Thorpe North & Western, December 5, 1995: US05472881 (220 worldwide citation)

A method for adsorbing nucleic acids to a surface of a gold substrate for analyzing the structure of the nucleic acid includes the steps of thiolating the nucleic acid by substituting at least one non-bridging internucleotide oxygen of each phosphodiester moiety with sulfur, depositing the thiolated ...


5
Mark P Heilbrun, Paul McDonald, J Clayton Wiker, Spencer Koehler, William Peters: Apparatus and method for photogrammetric surgical localization. University of Utah Research Foundation, Trask Britt & Rossa, February 18, 1997: US05603318 (215 worldwide citation)

A method and apparatus for defining the location of a medical instrument relative to features of a medical workspace including a patient's body region are described. Pairs of two-dimensional images are obtained, preferably by means of two video cameras making images of the workspace along different ...


6
James N Herron, Douglas A Christensen, Hsu Kun Wang, Karin D Caldwell, Vera Janatova, Shao Chie Huang: Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays. University of Utah Research Foundation, Trask Britt & Rossa, October 14, 1997: US05677196 (205 worldwide citation)

Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semi-cylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field intensity. A preferred embodiment of the biosens ...


7
B Ajit Kumar, Pratap Khanwilkar, Don B Olsen: Method and apparatus for providing a conductive, amorphous non-stick coating. MedQuest Products, University of Utah Research Foundation, Holland & Hart, August 7, 2001: US06270831 (199 worldwide citation)

A conductive, non-stick coating is provided using a ceramic material which is conductive, flexible and provides a surface which exhibits the property of lubricity. A room or near room temperature manufacturing process produces a coating of titanium nitride on a substrate, where the coating is amorph ...


8
Mark Peter Heilbrun, Paul McDonald, J Clayton Wiker, Spencer Koehler, William Peters: Apparatus and method for photogrammetric surgical localization. University of Utah Research Foundation, Trask Britt & Rossa, November 17, 1998: US05836954 (188 worldwide citation)

A method and apparatus for defining the location of a medical instrument relative to features of a medical workspace including a patient's body region are described. Pairs of two-dimensional images are obtained, preferably by means of two video cameras making images of the workspace along different ...


9
Mario R Capecchi, Kirk R Thomas: Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same. University of Utah Research Foundation, Townsend and Townsend and Crew, January 30, 1996: US05487992 (173 worldwide citation)

Positive-negative selector (PNS) vectors are provided for modifying a target DNA sequence contained in the genome of a target cell capable of homologous recombination. The vector comprises a first DNA sequence which contains at least one sequence portion which is substantially homologous to a portio ...


10
Robert L Stephen, Carl Kablitz, Barry K Hanover, Stephen C Jacobsen, Jeffrey J Harrow: Subcutaneous peritoneal injection catheter. University of Utah Research Foundation, H Ross Workman, Allen R Jensen, Berne S Broadbent, September 20, 1983: US04405305 (142 worldwide citation)

A novel implantable, peritoneal injection catheter apparatus and method, the apparatus including an open top, fluid-receiving reservoir mounted to one end of a hollow stem and a penetrable membrane covering the open top of the receiving reservoir. The hollow stem is configurated to extend into the p ...



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