1
Patrick J Ryan, Michael A Davis, Donald L Melchior: Liposomes containing modified cholesterol for organ targeting. Trustees University of Massachusetts, Paul J Cook, October 1, 1985: US04544545 (549 worldwide citation)

Phospholipid liposomes are provided having an outer layer including a cholesterol derivative such as a cholesterol ester and an aqueous medium confined by the layer which includes a tracer agent, a cytoxic agent or a therapeutic agent. The liposomes are adapted for specific organ targeting.


2
Leo C T Fung, Steven W Ek: Suture collet. Smith & Nephew, University of Massachusetts, Fish & Richardson P C, March 13, 2001: US06200329 (453 worldwide citation)

A suture securing device includes an inner member defining a suture receiving passage extending between a distal end surface of the inner member and a second surface of the inner member. An outer member defines an opening for receiving the inner member such that suture extending from the second surf ...


3
Javier Verdura, Maureen E Carroll, Richard Beane, Steven Ek, Mark P Callery: Systems, methods, and instruments for minimally invasive surgery. Smith & Nephew, University of Massachusetts, Fish & Richardson P C, December 12, 2000: US06159200 (371 worldwide citation)

Systems, methods, and miniature instruments are disclosed for minimally invasive surgical procedures. A miniature surgical instrument can be inserted directly into a body cavity through a cannula in a way that a surgeon can insert his or her hand into the cavity through a separate minimal incision a ...


4
Javier Verdura, Maureen E Carroll, Richard Beane, Steven Ek, Mark P Callery: Systems methods and instruments for minimally invasive surgery. Smith & Nephew, University of Massachusetts, Fish & Richardson P C, December 26, 2000: US06165184 (349 worldwide citation)

Systems, methods, and miniature instruments are disclosed for minimally invasive surgical procedures. A miniature surgical instrument can be inserted directly into a body cavity through a cannula in a way that a surgeon can insert his or her hand into the cavity through a separate minimal incision a ...


5
Richard Beane, Steve Ek, Allison C Niemann, Maureen E Carroll, Randall J Hasslinger, Edward I Stamm Jr, Javier Verdura: Device, surgical access port, and method of retracting an incision into an opening and providing a channel through the incision. University of Massachusetts, Smith & Nephew, Fish & Richardson P C, May 25, 1999: US05906577 (306 worldwide citation)

A device for retracting edges of an incision in a surface to form an opening including: a flexible, tubular skirt having an upper end, a lower end, and a channel therebetween; a ring connected to the lower end of the skirt for maintaining the lower end in an open configuration and defining an exit o ...


6
Patrick J Ryan, Michael A Davis, Donald L Melchior: Lipisomes containing gas for ultrasound detection. Trustees of the University of Massachusetts, Paul J Cook, February 13, 1990: US04900540 (250 worldwide citation)

Phospholipid liposomes are provided having a lipid bilayer surrounding a confined composition which includes a gas or a gas precursor. The liposomes can be administered to a patient and can be detected in vivo by ultrasound techniques which permit organ imaging.


7
Richard Beane, Steve Ek, Allison C Niemann, Maureen E Carroll, Randall J Hasslinger, Edward I Stamm Jr, Javier Verdura: Surgical access port and laparoscopic surgical method. University of Massachusetts, Fish & Richardson P C, August 27, 2002: US06440063 (216 worldwide citation)

A device for retracting edges of an incision in a surface to form an opening including: a flexible, tubular skirt having an upper end, a lower end, and a channel therebetween; a ring connected to the lower end of the skirt for maintaining the lower end in an open configuration and defining an exit o ...


8
Steven W Ek, A Alan Conlan: Instrument for thoracic surgical procedures. University of Massachusetts, Smith & Nephew, Lahive & Cockfield, May 18, 1999: US05904702 (211 worldwide citation)

An instrument for performing thoracic surgical procedures including an instrument body, a tool assembly, and an actuating mechanism. The instrument body has a proximal end spaced along a longitudinal axis from a distal end. The tool assembly has two cooperating tool members operably connected to the ...


9
Babs R Soller, Tania Khan: Probe for localized tissue spectroscopy. University of Massachusetts, Nutter McClennen & Fish, May 13, 2003: US06564088 (202 worldwide citation)

An optical probe structure for illuminating and collecting returned light from a region of tissue. The optical probe is configured with illumination and collection windows to controllably collect light from the region of tissue in vivo. The probe is designed to have a defined spacing between the fib ...


10
Richard Beane, Steve Ek, Allison C Niemann, Maureen E Carroll, Randall J Hasslinger, Edward I Stamm Jr, Javier Verdura: Surgical access port and method for accessing a patients body cavity. University of Massachusetts, Fish & Richardson P C, November 7, 2000: US06142936 (191 worldwide citation)

A device for retracting edges of an incision in a surface to form an opening including: a flexible, tubular skirt having an upper end, a lower end, and a channel therebetween; a ring connected to the lower end of the skirt for maintaining the lower end in an open configuration and defining an exit o ...