1
John P Albright, Robert K Martin, John A Dyson: Suturing device and method for using same. University of Iowa Research Foundation, Zarley McKee Thomte Voorhees & Sease, January 15, 1985: US04493323 (478 worldwide citation)

The device of the present invention comprises an elongated tube which is adapted to be inserted into the body so that its internal end is positioned adjacent the tissue which is to be sutured. A plunger is sized to slide within the tube and includes at one end a grasping mechanism for releaseably gr ...


2
Joseph A Walder, Roxanne Y Walder: Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved. University of Iowa Research Foundation, Seed and Berry, April 4, 1995: US05403711 (409 worldwide citation)

A method of detection of nucleic acid (DNA or RNA) target sequence in which such a sequence serves as a cofactor for a catalytic reaction in which a complementary, labeled nucleic acid probe is cleaved such that the target sequence is released intact and can repeatedly recycle through the reaction p ...


3
Arthur M Krieg, Joel Kline, Dennis Klinman, Alfred D Steinberg: Immunostimulatory nucleic acid molecules. University of Iowa Research Foundation, Coley Pharmaceutical Group, The United States of America represented by the Department of Health and Human Services, Wolf Greenfield & Sacks P C, March 27, 2001: US06207646 (345 worldwide citation)

Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed.


4
Arthur M Krieg, Joel N Kline: Immunostimulatory nucleic acid molecules. University of Iowa Research Foundation, Coley Pharmaceutical Group, The United States of America represented by the Department of Health and Human Services, Wolf Greenfield & Sacks P C, May 29, 2001: US06239116 (329 worldwide citation)

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.


5
Heather L Davis, Joachim Schorr, Arthur M Krieg: Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant. University of Iowa Research Foundation, Coley Pharmaceutical, Ottawa Health Research Institute, Wolf Greenfield & Sacks P C, June 18, 2002: US06406705 (291 worldwide citation)

The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be ...


6
Mark F Stinski: Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence. University of Iowa Research Foundation, Seed and Berry, December 1, 1992: US05168062 (282 worldwide citation)

The cloning of a eucaryotic promoter-regulatory region that functions preferentially in human cells is disclosed. The invention is exemplified by the cloning of a section of the human cytomegalovirus genome comprising a DNA sequence with regulatory and promoter signals and an initiation site for RNA ...


7
Arthur M Krieg, Dennis Klinman, Alfred D Steinberg: Immunomodulatory oligonucleotides. The University of Iowa Research Foundation, The United States of America, Coley Pharmaceutical Group, Wolf Greenfield & Sacks P C, February 27, 2001: US06194388 (238 worldwide citation)

Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinuc ...


8
Arthur M Krieg, Heather L Davis, Tong Wu, Joachim Schorr: Vectors and methods for immunization or therapeutic protocols. University of Iowa Research Foundation, Loeb Health Research Institute at the Ottawa Hospital, Coley Pharmaceutical, Wolf Greenfield & Sacks P C, January 15, 2002: US06339068 (230 worldwide citation)

The present invention shows that DNA vaccine vectors can be improved by removal of CpG-N motifs and optional addition of CpG-S motifs. In addition, for high and long-lasting levels of expression, the optimized vector should include a promoter/enhancer that is not down-regulated by the cytokines indu ...


9
Arthur M Krieg, Gunther Hartmann: Immunostimulatory nucleic acid molecules for activating dendritic cells. University of Iowa Research Foundation, Wolf Greenfield & Sacks P C, August 6, 2002: US06429199 (219 worldwide citation)

The present invention relates generally to methods and products for activating dendritic cells. In particular, the invention relates to oligonucleotides which have a specific sequence including at least one unmethylated CpG dinucleotide which are useful for activating dendritic cells. The methods ar ...


10
Matthew A Howard III: Stereotactic hypothalamic obesity probe. The University of Iowa Research Foundation, Fleshner & Kim, October 10, 2000: US06129685 (195 worldwide citation)

Apparatus and methods for regulating the appetite of an individual suffering from morbid obesity, the apparatus including a plurality of stimulation electrodes arranged longitudinally on at least one electrode support shaft for insertion within the hypothalamus for outputting electrical discharges t ...