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Mohamed SKIBA Mohamed SKIBA
Skiba Mohamed, Skiba Malika, Duclos Roselyne, Combret Jean Claude, Arnaud Philippe: Cyclodextrines monosubstitues a persubstitues par des groupements fluoroalkyles, leur preparation et leur utilisation. Univ Rouen, February 2, 2001: FR2796955-A1

The invention concerns alpha, beta or gamma cyclodextrin derivatives, monosubstituted to persubstituted on the primary and/or secondary hydroxyl groups by one or several identical or different fluoroalkyl groups. The invention also concerns nanoparticles consisting of said cyclodextrin derivatives, ...


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Mohamed SKIBA Mohamed SKIBA
Skiba Mohamed, Skiba Malika, Duclos Roselyne, Combret Jean Claude, Arnaud Philippe: Cyclodextrins substituted by fluoroalkyl groups, preparation and use thereof. Univ Rouen, August 21, 2002: EP1232188-A1

The invention concerns alpha, beta or gamma cyclodextrin derivatives, monosubstituted to persubstituted on the primary and/or secondary hydroxyl groups by one or several identical or different fluoroalkyl groups. The invention also concerns nanoparticles consisting of said cyclodextrin derivatives, ...


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Coquerel Gerard, Petit Marie Noelle, Bouaziz Roger: Method of resolution of two enantiomers by crystallization. Univ Rouen, July 10, 1996: EP0720595-A1 (11 worldwide citation)

A method of optical enantiomer resolution by preferential crystallization involves entering, each time crystallization starts, the two-phase domain containing excess enantiomer and the saturated solution, and cooling according to a well-defined kinetic schedule. A racemic mixture of fine particle si ...


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Coquerel Gerard, Tauvel Guillaume, Petit Marie Noelle: Procede de dedoublement de sels de lomeprazole. Univ Rouen, March 6, 2009: FR2920428-A1 (4 worldwide citation)

La présente invention concerne le dédoublement par cristallisation préférentielle de sels de potassium de l'Oméprazole racémique solvate de : méthanol et/ou d'éthanol et/ou d'éthylèneglycol consistant à transformer l'Oméprazole en sel de potassium sous forme d'un solvate ou d'un mélange de ces solva ...


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Tranchand Bunel Denis: New antigen from intracellular pathogens, useful in vaccines against bacterial and viral infections, comprises sequences from extracellular domains of type iii membrane proteins, also derived antibodies. Centre Nat Rech Scient, Univ Rouen, Univ Lille 2, July 30, 2004: FR2850384-A1 (1 worldwide citation)

Antigen (Ag) derived from an intracellular pathogenic microorganism (A) comprises at least one peptide fragment (F) consisting of the concatenation of the sequences of at least two adjacent extracellular domains (ECD) in the native structure of a type III membrane protein (PIII), having an even numb ...


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Tranchand Bunel Denis: Antigen imitating extracellular areas of membrane proteins of type iii produced from intracellular pathogenic micro-organisms, derived conformational antibodies and the use thereof. Centre Nat Rech Scient, Univ Rouen, Univ Lille Ii, October 26, 2005: EP1587825-A2 (1 worldwide citation)

Antigen (Ag) derived from an intracellular pathogenic microorganism (A) comprises at least one peptide fragment (F) consisting of the concatenation of the sequences of at least two adjacent extracellular domains (ECD) in the native structure of a type III membrane protein (PIII), having an even numb ...


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CHOUIPPE SNELLA, SCHNEIDER JEAN MARIE, TAUVEL GUILLAUME, COQUEREL GERARD: Precursor phase and use thereof for preparing the magnesium salt tetrahydrate of an omeprazole enantiomer, Ausgangsphase und ihre Verwendung zur Herstellung des Tetrahydrat-Magnesiumsalzes eines Enantiomers vom Omeprazol, Phase précurseur et son utilisation pour préparer le sel de magnésium tétrahydraté dun énantiomère doméprazole. PROD CHIM AUXILIAIRES ET DE SYNTHESE, UNIV ROUEN, November 9, 2011: EP2385046-A1

La présente invention concerne une phase précurseur du sel de magnésium tétrahydraté d'un énantiomère d'oméprazole, ainsi que ses procédés de préparation et son utilisation pour la préparation dudit sel de magnésium tétrahydraté. Elle concerne également les cristaux du sel de magnésium tétrahydraté ...


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Renard Pierre Yves, Romieu Anthony, Richard Jean Alexandre, Massonneau Marc: Nouveaux composes pro-fluorescents.. Quidd Soc Par Actions Simplifi, Univ Rouen, July 4, 2008: FR2910897-A1

La présente invention concerne un composé pro-fluorescent de formule générale (I) :A-B-X-F (I)dans laquelle A figure une structure labile activable par un phénomène physique, chimique ou biologique, B figure un bras réactif, activable par libération de A et apte à générer un radical portant un subst ...