1
Cerami Anthony, Kawakami Masanobu: Anabolic activity modulator and uses thereof.. Univ Rockefeller, March 4, 1987: EP0212489-A2 (154 worldwide citation)

A modulator material is disclosed which has been isolated from macrophage cells that have been incubated with a stimulator material from an invasive stimulus. The modulator material comprises a protein that exhibits the ability to substantially completely suppress the activity of the anabolic enzyme ...


2
Cerami Anthony, Kawakami Masanobu: Antibody to a mediator activity composition and its use in a pharmaceutical composition.. Univ Rockefeller, March 7, 1984: EP0101681-A1 (116 worldwide citation)

Mediator substances exhibiting inhibitory effect upon anabolic enzyme activity in mammals, are prepared by a method comprising gathering a sample of macrophage cells from a mammal, incubating a portion of the macrophage cells with a stimulating material that is associated with an invasive event, and ...


3
Kreek Mary Jeanne, Fishman Jack: Method of treating patients suffering from chronic pain or chronic cough.. Univ Rockefeller, January 31, 1990: EP0352361-A1 (93 worldwide citation)

A method for treating patients in chronic pain or suffering from chronic cough over a prolonged period to provide systemic analgesia or central antitussive effect while simultaneously avoiding the onset of intestinal hypomotility. The method includes the oral administration to the patient of dosage ...


4
Cerami Anthony, Ulrich Peter, Brownlee Michael: Method and agents for inhibiting protein aging.. Univ Rockefeller, May 20, 1987: EP0222313-A2 (57 worldwide citation)

The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of t ...


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Buxbaum Joseph D, Gandy Samuel E, Greengard Paul: Use of a modulator of protein phosphorylation in the treatment of amyloidosis associated with alzheimers disease.. Univ Rockefeller, November 21, 1991: EP0457295-A2 (40 worldwide citation)

Disclosed is the use of at lease one kinase modulator or phosphatase modulator being capable of increasing or decreasing the rate of proteolytic processing of proteins found in intracellular neurofibrillary tangles and extracellular amyloid plaques for the preparation of a pharmaceutical composition ...


7
Gabay Joelle E, Nathan Carl F: Antimicrobial proteins, compositions containing same and uses thereof.. Cornell Res Foundation, Univ Rockefeller, June 29, 1988: EP0272489-A2 (38 worldwide citation)

The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises at least two polypeptides selected from the group consisting of human polymorphonuclear leukocyte polypeptides having apparent molecular weights of about 3,500 daltons, about ...


8
Wright Samuel D, Tuomanen Elaine I: Method of inhibiting the influx of leukocytes into organs during sepsis or other trauma.. Univ Rockefeller, December 13, 1989: EP0346078-A2 (25 worldwide citation)

The influx of leukocytes into the lung and other organs during sepsis or other infectious or non-infectious trauma can be inhibited by the administration of anti-CD18 monoclonal antibodies. Such inhibition results in a prevention and/or diminishment of organ damage in inflammations and especially in ...


9
Ulrich Peter C, Cerami Anthony: Inhibitors of nonenzymatic cross-linking.. Univ Rockefeller, May 24, 1989: EP0316852-A2 (24 worldwide citation)

The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises ; an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the ca ...


10
Cerami Anthony, Beutler Bruce, Wolpe Stephen D: Macrophage-derived inflammatory mediator (mip-1alpha and mip-1beta).. Univ Rockefeller, April 5, 1989: EP0310136-A2 (21 worldwide citation)

An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of binding to heparin, inducing localized inflammation characterized by polymorphonuclear cell infiltration when ...