1
David A Roberts, John S Leigh Jr: MR angiography using steady-state transport-induced adiabatic fast passage. Trustees of the University of Penna, Woodcock Washburn Kurtz Mackiewicz & Norris, June 14, 1994: US05320099 (36 worldwide citation)

A subtractive time of flight technique for MR angiography and quantitative blood flow measurement. Proton spins of water in the arterial supply to a tissue or organ are inverted in a steady-state fashion by applying constant amplitude off-resonance radio frequency pulses in the presence of a constan ...


2
Alan G MacDiarmid, Xun Tang: Cross-linked polymers derived from polyaniline and gels comprising the same. Trustees of the University of Penna, Woodcock Washburn Kurtz Mackiewicz & Norris, September 15, 1992: US05147913 (27 worldwide citation)

Cross-linked polymer networks derived from polyaniline and polyaniline derivatives are provided, as well as preparative methods therefor. Also provided are gels comprising cross-linked polymer and a liquid.


3
John S Leigh, John A Detre, Donald S Williams, Alan P Koretsky: Methods for measuring perfusion using magnetic resonance imaging. Trustees of the University of Penna, Carnegie Mellon University, Woodcock Washburn Kurtz Mackiewicz & Norris, April 4, 1995: US05402785 (20 worldwide citation)

Methods for measuring the perfusion of fluid in a substance are shown to include subjecting the fluid to electromagnetic energy so as to cause a response related to the magnetization of the fluid before it enters the substance, performing magnetic resonance measurements on the substance to generate ...


4
John S Leigh, Meir Shinnar: Methods of generating pulses for selectively exciting frequencies. Trustees of the University of Penna, Woodcock Washburn Kurtz Mackiewicz & Norris, October 6, 1992: US05153515 (11 worldwide citation)

Methods of constructing pulse sequences to selectively excite frequency bands in NMR imaging, spectroscopic and optical systems are disclosed. In preferred embodiments, selective .pi./2, .pi., and refocusing hard and soft pulses are constructed for perturbing the spins of the system. In NMR imaging, ...


5
Richard A Stone, Alan M Laties, Paul M Iuvone: Pharmacological treatment of ocular development. Trustees of the University of Penna, Emory University, Woodcock Washburn Kurtz MacKiewicz & Norris, February 8, 1994: US05284843 (8 worldwide citation)

A method of inhibiting the abnormal postnatal axial growth of the eye of a maturing animal during conditions ordinarily leading to said abnormal growth, which comprises (1) determining the neurochemical present in the retina of said eye, eg., dopamine, the concentrations of which is reduced during s ...


6
Sanford J Shattil, Rebecca A Taub, Paul A Friedman: Inhibitors of platelet binding. Trustees of the University of Penna, Merck Company, Woodcock Washburn Kurtz Mackiewicz & Norris, December 8, 1992: US05169836 (2 worldwide citation)

Peptides comprising the tripeptide sequence of arginine-tyrosine-aspartic acid, linked from amino- to carboxy-terminus, are inhibitors of fibrinogen binding, platelet aggregation, glycoprotein IIb-IIIa binding and related aberrant and normal physiological conditions.


7
Kyriacos C Nicolaou, Guido Zuccharello, Yuji Ogawa: Cyclic conjugated enediynes. Trustees of the University of Penna, Woodcock Washburn Kurtz Mackiewicz & Norris, August 24, 1993: US05239118 (1 worldwide citation)

The synthesis of stable, ten-membered, cyclic conjugated enediynes is described. Said compounds were successfully employed to cleave double-stranded DNA spontaneously at ambient temperatures.