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Truong Le Vu, Scherer Tom: High pressure spray-dry of bioactive materials. Medimmune Vaccines, Truong Le Vu, Scherer Tom, QUINE Jonathan Alan, December 29, 2005: WO/2005/123131 (16 worldwide citation)

This invention provides compositions and methods providing, e.g., stable powder particles containing bioactive materials. The methods include, e.g., high pressure spraying of the bioactive materials in solution or suspension, with viscosity enhancing agents, organic solvents, and/or surfactants. For ...


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Truong Le Vu, Scherer Tom: High pressure spray-dry of bioactive materials. Medimmune Vaccines, Truong Le Vu, Scherer Tom, QUINE Jonathan Alan, July 15, 2004: WO/2004/058156 (14 worldwide citation)

This invention provides compositions and methods providing, e.g., stable powder particles containing bioactive materials. The methods include, e.g., high pressure spraying of the bioactive materials in solution or suspension, with viscosity enhancing agents and/or surfactants. Compositions of the in ...


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Truong Le Vu, Yee Luisa, Lechuga Ballesteros David, Ohtake Satoshi: Formulations for preservation of rota virus. Aridis Pharmaceuticals, Truong Le Vu, Yee Luisa, Lechuga Ballesteros David, Ohtake Satoshi, QUINE Jonathan Alan, April 2, 2009: WO/2009/042202 (2 worldwide citation)

This invention provides formulations and methods for stabilizing viruses in liquid and dried formulations. In particular, formulations are provided including Zn2+ cations that stabilize the viability of Rotaviruses. Methods of vaccination include neutralization of gastric contents and administration ...


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Randolph Theodore W, Seid Robert, Truong Le Vu, Pham Binh V, Carpenter John F: Spray freeze dry of compositions for intranasal administration. Medimmune Vaccines, The Regents Of The University Of Colorado, Randolph Theodore W, Seid Robert, Truong Le Vu, Pham Binh V, Carpenter John F, QUINE Jonathan Alan, October 23, 2003: WO/2003/086443 (1 worldwide citation)

This invention provides methods and compositions to preserve bioactive materials, such as peptides, nucleic acids, viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for intranasal administration. Methods provide spray freeze drying of formulations to form stable freeze dried ...


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Truong Le Vu, Pham Binh: Preservation of bioactive materials by spray drying. Medimmune Vaccines, Truong Le Vu, Pham Binh, QUINE Jonathan Alan, October 23, 2003: WO/2003/087335

This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure-gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form stable powder particles containing ...


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Truong Le Vu, Pham Binh V, Carpenter John F, Seid Robert, Randolph Theodore: Spray freeze dry of compositions for pulmonary administration. Medimmune Vaccines, The Regents Of The University Of Colorado, Truong Le Vu, Pham Binh V, Carpenter John F, Seid Robert, Randolph Theodore, QUINE Jonathan Alan, October 23, 2003: WO/2003/087339

This invention provides methods and compositions to preserve bioactive materials, such as viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for pulmonary administration. Methods provide spray freeze drying of formulations to form stable freeze dried particles.


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TRUONG LE VU: Formulation for room temperature stabilization of a live attenuated bacterial vaccine. TRUONG LE VU, March 17, 2011: WO/2011/032108

This invention provides methods and compositions for stabilizing proteins and vaccines in dried formulations. In particular, a cavitation method and compositions of preparing a dried vaccine are provided that stabilize the viability of live bacteria and live virus vaccines at room temperature.


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Truong Le Vu: Influencing viral lipid constituents. Medimmune, Truong Le Vu, QUINE Jonathan Alan, July 24, 2008: WO/2008/088410

This invention provides compositions, methods and systems to modulate the lipid content and membrane characteristics of cells and virions. Growth of host cells on media containing particular amounts, classes and/or combinations of lipid supplements can influence the lipid content of the cell and vir ...