1
Messerschmidt Robert G, Childs Jim, Trepagnier Pierre, Mansfield James, Freeman Jenny E, Toy Sean, Chance Britton: Optical coupler for measuring tissue fluorescence. Argose, Messerschmidt Robert G, Childs Jim, Trepagnier Pierre, Mansfield James, Freeman Jenny E, Toy Sean, Chance Britton, REMENICK James, February 6, 2003: WO/2003/010561

The present invention is directed to a device for efficiently optically coupling an area of tissue to a spectroscope. The optical coupler preferably comprises a rigid partial enclosure having an inside wall that reflects electromagnetic radiation, an opening on the enclosure for the passage of light ...


2
Apruzzese William, Trepagnier Pierre, Gray Russell, Mansfield James, Lambert Christopher: Layered calibration standard for tissue sampling. Argose, Apruzzese William, Trepagnier Pierre, Gray Russell, Mansfield James, Lambert Christopher, REMENICK James, August 15, 2002: WO/2002/063269

The invention relates to fluorescence calibration devices and methods that can mimic skin and other tissues. A calibration device (100) of the invention comprises at least one scattering layer (110), which is preferably non-fluorescent, and a second layer (120) containing one or more fluorophore (12 ...


3
Trepagnier Pierre: Asynchronous fluorescence scan. Argose, Trepagnier Pierre, sREMENICK James, May 10, 2001: WO/2001/033201

The present invention is directed to asynchronous scanning devices and methods of using asynchronous scanning to acquire fluorescence data from a sample, such as biological tissue, to facilitate diagnosis of the presence or absence of disease or other abnormality in the sample. The present invention ...


4
Brand Derek, Freeman Jenny, Mansfield James, Trepagnier Pierre: Reduction of inter-subject variation via transfer standardization. Argose, Brand Derek, Freeman Jenny, Mansfield James, Trepagnier Pierre, sREMENICK James, August 23, 2001: WO/2001/061319

This invention relates to the reduction of inter-subject variation via transfer standardization. According to the method, the effects of inter-subject variation on the analysis of spectra collected from the skin of two or more different subjects is reduced by correcting for the differences between s ...


5
Tian Wei D, Trepagnier Pierre: Generation of spatially-averaged excitation-emission map in heterogeneous tissue. Argose, Tian Wei D, Trepagnier Pierre, sREMENICK James, August 23, 2001: WO/2001/060247

An instrument for evaluating fluorescence of a heterogeneous tissue includes means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-dimensional portion of the tissue s ...


6
Trepagnier Pierre, Freeman Jenny, Mansfield James, Brand Derek, Hopmeier Michael J, Kollias Nikiforos: Non-invasive tissue glucose level monitoring. Argose, Trepagnier Pierre, Freeman Jenny, Mansfield James, Brand Derek, Hopmeier Michael J, Kollias Nikiforos, sREMENICK James, August 23, 2001: WO/2001/060248

Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.


7
Bushmakin Andrew, Trepagnier Pierre, Mansfield James: Pre-and post-processing of spectral data for calibration using multivariate analysis techniques. Argose, Bushmakin Andrew, Trepagnier Pierre, Mansfield James, REMENICK James, November 22, 2001: WO/2001/088510

This invention relates to a method for quantitating the relationship between an analyte level in in vivotissue and the auto-fluorescent spectral characteristics in the tissue.


8
Freeman Jenny, Mansfield James, Pierce Andrea, Trepagnier Pierre, Hopmeier Michael J: Interface medium for tissue surface probe. Argose, Freeman Jenny, Mansfield James, Pierce Andrea, Trepagnier Pierre, Hopmeier Michael J, sREMENICK James, May 10, 2001: WO/2001/033278

A composition useful as an interface medium to optically couple and facilitate contact between a probe and a tissue surface, such as skin, is described. Compositions of the present invention have an index of refraction of approximately 1.4, which approximates the indices of both the skin and the pro ...



Click the thumbnails below to visualize the patent trend.