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Kimio Mizuno, Tetsuo Matsuda, Katsumi Asano, Akira Yagi, Masaki Takada, Tetsu Saito, Minoru Toriya, Shuzo Satoi, Kazuo Matsuura: Antibiotic aculeacins. Toyo Jozo Kabushiki Kaisha, Young & Thompson, August 31, 1976: US03978210 (39 worldwide citation)

A family of antibiotics active against pathogenic yeasts and fungi comprises aculeacin-A, -B, -C, -D, -E, -F, and -G. These are produced from cultured broth of Aspergillus aculeatus FERM-P 2324.


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Shizuo Ina, Shoji Tokura: Self-heating container. Toyo Jozo Kabushiki Kaisha, Ueda Lime Manufacturing, Young & Thompson, May 3, 1988: US04741324 (36 worldwide citation)

A container capable of heating the contents of the container from inside, having at its bottom a cylindrical inner shell made of a thermoconductive material opening downward and defining internally of itself a reaction chamber in which are disposed an active substance and a reacting substance capabl ...


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Kaoru Morita, Shigeo Katsuragi, Toshiharu Noda: [Nle.sup.8, Nle.sup.18, Tyr.sup.34 or Phe.sup.34 ]-h-PTH peptide derivatives. Toyo Jozo Kabushiki Kaisha, Young & Thompson, April 7, 1987: US04656250 (34 worldwide citation)

A peptide of the formula ##STR1## wherein A is Tyr or Phe, or a pharmaceutically acceptable salt thereof, is useful for the diagnosis of parathyroid gland function. When A is Tyr, the peptide can be labelled with iodine-125 without losing its PTH activity and without undergoing oxidation upon storag ...


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Satoshi Shuto, Hiromichi Ito, Kiyofumi Fukukawa, Hideo Sakakibara, Masatoshi Tsujino: Nucleoside-phospholipid conjugate. Toyo Jozo Kabushiki Kaisha, Young & Thompson, January 10, 1989: US04797479 (29 worldwide citation)

A compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are long-chain fatty acid residue, and Ns is nucleoside residue selected from the group consisting of 5-fluorouridine-5'-yl, 5-fluoro-2'-deoxyuridine-5'-yl-, bredinin-5'-yl, tubercidine-5'-yl-, neplanocin A-6'-yl-, 5-fluorocytidine-5'-yl ...


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Shumpei Sakakibara, Tadanori Morikawa, Eisuke Munekata, Terutoshi Kimura, Yasuo Nakagawa, Toshiharu Noda: Polypeptides and process for producing the same. Toyo Jozo Kabushiki Kaisha, Young & Thompson, April 25, 1978: US04086221 (27 worldwide citation)

Polypeptides of the formula ##STR1## wherein A.sub.1 is Ser or Gly, A.sub.7 is Val or Met, A.sub.10 is Lys or Thr, A.sub.11 is Leu or Tyr, A.sub.12 is Ser or Thr, A.sub.14 is Glu or Asp, A.sub.15 is Leu or Phe, A.sub.16 is His or Asn, A.sub.18 is Leu or Phe, A.sub.19 is Gln or His, A.sub.21 is Tyr o ...


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Satoshi Shuto, Hiromichi Itoh, Kiyofumi Fukukawa, Masatoshi Tsujino: Nucleoside-phospholipid conjugate. Toyo Jozo Kabushiki Kaisha, Young & Thompson, May 1, 1990: US04921951 (25 worldwide citation)

Novel nucleoside-phospholipid conjugates of the formula ##STR1## wherein R.sub.1 is C.sub.14-24 long chain aliphatic acyl or C.sub.1-24 aliphatic alkyl and N.sub.s is a nucleoside residue; and pharmacologically acceptable salts thereof are prepared in a one-step reaction by reacting the correspondin ...


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Kunio Matsumoto, Tsutomu Hirata: Enzymatic assay method. Toyo Jozo Kabushiki Kaisha, Young & Thompson, July 21, 1987: US04681841 (20 worldwide citation)

A method for assaying a compound of the formula ##STR1## wherein R.sub.1 is hydroxyl or amino, or hydrogen if at least one of R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is hydroxyl or amino, and R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen, halogen, lower alkyl, lower alkoxy, amin ...


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Hideo Misaki, Eiji Muramatsu, Hidehiko Ishikawa, Kazuo Matsuura: Assay method for amylase activity and method of producing maltose dehydrogenase for use therein. Toyo Jozo Kabushiki Kaisha, Young & Thompson, January 24, 1984: US04427771 (18 worldwide citation)

An assay method for amylase activity in a biological specimen such as serum, saliva or urine. The enzyme amylase in the specimen is used to decompose a substrate which is a glucose polymer having a modified reducing terminal glucose residue or a cyclic glucose polymer. A component of the decomposed ...