1
Min Jing, Wu Yanli, Finn Rory Francis, Thiele Barrett Richard, Laio Wei, Gladue Ronald Paul, Rajpal Arvind, Paradis Timothy Joseph, Brams Peter, Devaux Brigitte, Wu Yi, Toy Kristopher, Leblanc Heidi N, Huang Haichun: Binding molecules to the human ox40 receptor. Medarex, Pfizer, Min Jing, Wu Yanli, Finn Rory Francis, Thiele Barrett Richard, Laio Wei, Gladue Ronald Paul, Rajpal Arvind, Paradis Timothy Joseph, Brams Peter, Devaux Brigitte, Wu Yi, Toy Kristopher, Leblanc Heidi N, Huang Haichun, BRADY James W, June 25, 2009: WO/2009/079335 (11 worldwide citation)

The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells comtaining the vectors, methods of making the binding molecules, pharmac ...


2
Terrett Jonathan A, Pogue Sarah L, Toy Kristopher, Yang Lan, Rao Naik Chetana, Chen Bingliang: Human antibodies that bind mesothelin, and uses thereof. Medarex, Terrett Jonathan A, Pogue Sarah L, Toy Kristopher, Yang Lan, Rao Naik Chetana, Chen Bingliang, FEHLNER Paul F, April 9, 2009: WO/2009/045957 (10 worldwide citation)

The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expr ...


3
Graziano Robert, Huang Haichun, Yang Lan, Toy Kristopher, Leblanc Heidi N: Human antibodies that bind multiple irta family proteins, and uses thereof. Medarex, Graziano Robert, Huang Haichun, Yang Lan, Toy Kristopher, Leblanc Heidi N, FEHLNER Paul F, September 12, 2008: WO/2008/109533 (5 worldwide citation)

The present disclosure provides isolated monoclonal antibodies that bind to multiple IRTA family proteins with high affinity, particularly human monoclonal antibodies. Preferred antibodies of the invention specifically bind an IRTA4 protein and at least one other IRTA family protein. Nucleic acid mo ...


4
Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark: Alpha 5 - beta 1 antibodies and their uses. Medarex, Pfizer, Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark, BRADY James W, August 13, 2009: WO/2009/100110 (5 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells ...


5
Rajpal Arvind, Devalaraja Madhav, Toy Kristopher, Yang Lan, Huang Halichun, Zhang Jun Z, Brams Peter, Devaux Brigitte, Passmore David B: Antibodies to il-6 and their uses. Medarex, Pfizer, Rajpal Arvind, Devalaraja Madhav, Toy Kristopher, Yang Lan, Huang Halichun, Zhang Jun Z, Brams Peter, Devaux Brigitte, Passmore David B, Brady James W, December 23, 2009: WO/2009/155180 (4 worldwide citation)

Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding port ...


6
Korman Alan, Halk Edward L, Wang Changyu, Thudium Kent B, Wang Lan, Toy Kristopher: Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof. Medarex, Korman Alan, Halk Edward L, Wang Changyu, Thudium Kent B, Wang Lan, Toy Kristopher, MURPHY Anina Det al, August 13, 2009: WO/2009/100140 (3 worldwide citation)

The present invention provides isolated monoclonal antibodies that bind to CTLA-4 and that are capable of increasing the response of T cells to antigenic stimulation in vivo yet the antibodies do not substantially block the binding of CTLA-4 to B7 ligands (e.g., B7-1 and B7-2) in vitro. Thus, the an ...


7
Xu Xu, Bedian Vahe, Meaddough Erika, Huang Haichun, Yang Lan, Toy Kristopher, Srinivasan Mohan, Badkar Advait V: Cd44 antibodies. Medarex, Pfizer, Xu Xu, Bedian Vahe, Meaddough Erika, Huang Haichun, Yang Lan, Toy Kristopher, Srinivasan Mohan, Badkar Advait V, BRADY James W, July 3, 2008: WO/2008/079246 (2 worldwide citation)

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to CD44, and that function to inhibit CD44. The invention also relates to heavy and light chain immunoglobulins derived from human CD44 antibodies and nucleic acid molecules encoding ...