Seth Lederman, Herb Harris: Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine. Tonix Pharma Holdings, Ropes & Gray, October 25, 2016: US09474728 (1 worldwide citation)

The present invention relates to methods for the treatment or prevention of fatigue associated with disordered sleep, for example, in multiple sclerosis, fibromyalgia, Fabry's disease, Parkinson's disease, or traumatic brain injury, using cyclobenzaprine. The present invention further relates to a b ...

Marino Nebuloni, Patrizia Colombo: Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride. TONIX PHARMA HOLDINGS, Ropes & Gray, May 2, 2017: US09636408

The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol or Amitriptyline HCl and mannitol.

Seth Lederman, Bruce Daugherty, Leland J Gershell, Darryl Rideout, Andrew Kawasaki: Isometheptene isomer. TONIX PHARMA HOLDINGS, Withers Bergman, August 2, 2016: US09403755

The invention relates to a purified Isometheptene compound comprising the structure according to Formula (I), or a hydrochloride, or a pharmaceutically acceptable addition salt thereof. In particular, the disclosure relates to the synthesis, purification and characterization of an Isometheptene isom ...

Gregory M Sullivan: Method for treating neurocognitive dysfunction. Tonix Pharma Holdings, Ropes & Gray, James F Haley Jr, Gabriele A Amodeo, April 19, 2016: US09314469

A method of treating corticosteroid-induced cognitive impairment comprises administering an effective amount of at least one compound of formula I, or pharmaceutically acceptable salts thereof, to a subject in need of such treatment. Formula I is: wherein: A is a bridge selected from the following r ...

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