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Rosenquist Åsa, Thorstensson Fredrik, Johansson Per Ola, Kvarnström Ingemar, Ayesa Susana, Classon Björn, Rakos Lazlo, Samuelsson Bertil: Hcv ns-3 serine protease inhibitors. Medivir, Tibotec Pharmaceuticals, Rosenquist Åsa, Thorstensson Fredrik, Johansson Per Ola, Kvarnström Ingemar, Ayesa Susana, Classon Björn, Rakos Lazlo, Samuelsson Bertil, AWAPATENT, August 11, 2005: WO/2005/073216 (105 worldwide citation)

Compounds of the formula (F) where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those portions of the inhibitor more distal to the nominal cleavage s ...


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De, Kock Herman Augustinus, Raboisson Pierre Jean Marie Bernard, Tahri Abdellah, Simmen Kenneth Alan, Nilsson Karl Magnus, Samuelsson Bengt Bertil, Rosenquist Åsa Annica Kristina, Antonov Dmitry: Macrocyclic inhibitors of hepatitis c virus. Tibotec Pharmaceuticals, Medivir, de, Kock Herman Augustinus, Raboisson Pierre Jean Marie Bernard, Tahri Abdellah, Simmen Kenneth Alan, Nilsson Karl Magnus, Samuelsson Bengt Bertil, Rosenquist Åsa Annica Kristina, Antonov Dmitry, DAELEMANS Frank, February 8, 2007: WO/2007/014920 (71 worldwide citation)

Inhibitors of HCV replication of formula (I), the N-oxides, salts, and stereochemically isomeric forms thereof, wherein each dashed line (represented by -------) represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is aryl or a saturated, a partially unsaturated ...


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Raboisson Pierre Jean Marie Bernard, de, Kock Herman Augustinus, Vendeville Sandrine Marie Helene, Hu Lili, Van de, Vreken Wim, Mc, Gowan David Craig, Tahri Abdellah, Surleraux Dominique Louis Nestor Ghislain, Simmen Kenneth Alan: Macrocylic inhibitors of hepatitis c virus. Tibotec Pharmaceuticals, Raboisson Pierre Jean Marie Bernard, de, Kock Herman Augustinus, Vendeville Sandrine Marie Helene, Hu Lili, Van de, Vreken Wim, Mc, Gowan David Craig, Tahri Abdellah, Surleraux Dominique Louis Nestor Ghislain, Simmen Kenneth Alan, DAELEMANS Frank, February 8, 2007: WO/2007/014919 (63 worldwide citation)

Inhibitors of HCV of formula (I), and the N-oxides, salts, and stereochemically isomeric forms thereof, wherein R1 is aryl or a saturated, a partially unsaturated or completely unsaturated 5 or 6 membered monocyclic or 8 to 12 membered bicyclic heterocyclic ring system containing one nitrogen, and o ...


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DEMIN SAMUËL DOMINIQUE: Diaryl ethers. TIBOTEC PHARMACEUTICALS, Daelemans Frank, October 28, 2010: WO/2010/122162 (63 worldwide citation)

Compounds of the formula (I): including any possible stereoisomers thereof, or a pharmaceutically acceptable salt and/or solvate thereof, as well as pharmaceutical formulations and the use of compounds of formula I as HCV inhibitors.


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De, Kock Herman Augustinus, Simmen Kenneth Alan, Jönsson Carl Erik Daniel, Ayesa, Alvarez Susana, Classon Björn Olof, Nilsson Karl Magnus, Rosenquist Åsa Annica Kristina, Samuelsson Bengt Bertil, Wallberg Hans Kristian: Macrocyclic inhibitors of hepatitis c virus. Tibotec Pharmaceuticals, Medivir, de, Kock Herman Augustinus, Simmen Kenneth Alan, Jönsson Carl Erik Daniel, Ayesa, Alvarez Susana, Classon Björn Olof, Nilsson Karl Magnus, Rosenquist Åsa Annica Kristina, Samuelsson Bengt Bertil, Wallberg Hans Kristian, DAELEMANS Frank, February 8, 2007: WO/2007/014923 (57 worldwide citation)

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is -OR6, -NH-SO2R7; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 ...