1
Xiaoguang Sun, Jeffrey I Joseph: Implantable sensor and system for measurement and control of blood constituent levels. Thomas Jefferson University, Panitch Schwarze Jacobs & Nadel P C, November 30, 1999: US05995860 (528 worldwide citation)

An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue has at least one source of radiation from infrared through visible light, arranged to direct the radiation at the tissue where it is affected by interaction with the tissue, and a plura ...


2
Jeffery I Joseph, Marc C Torjman: Implantable drug delivery catheter system with capillary interface. Thomas Jefferson University, Drinker Biddle & Reath, October 29, 2002: US06471689 (424 worldwide citation)

The present invention relates to a drug delivery device which is implantable within a mammal and adapted for long-term efficient drug delivery to surrounding tissue. The drug delivery device is part of a drug delivery system that includes a catheter and a drug feed system. The drug delivery device i ...


3
Eric B Kmiec: Compounds and methods for site directed mutations in eukaryotic cells. Thomas Jefferson University, Pennie & Edmonds, October 15, 1996: US05565350 (346 worldwide citation)

The present invention concerns a polynucleotide having both ribonucleotides and deoxyribonucleotides in a first strand and solely deoxyribonucleotides in a second strand; wherein the strands are Watson-Crick paired and are linked by an oligonucleotide so that the polynucleotide has at most a single ...


4
Arnold J Greenspon, David K Swanson, Dorin Panescu, Steve S Hsu, James G Whayne: Tissue characterization and treatment using pacing. Thomas Jefferson University, Boston Scientific Corporation, Lyon & Lyon, September 21, 1999: US05954661 (217 worldwide citation)

Heart tissue is characterized by using pacing without inducing ventricular tachycardia (VT). With the tissue characterization, a patient's risk of developing VT can be determined and a slow conduction zone in the patient's heart can be determined. The characterization involves applying pacing signal ...


5
Jeffrey I Joseph: Methods and apparatus for reducing tracheal infection. Thomas Jefferson University, Woodcock Washburn Kurtz Mackiewicz & Norris, October 13, 1998: US05819723 (192 worldwide citation)

An integrated system providing a mechanical and chemical barrier against the spread of infected secretions into the distal trachea is disclosed. An endotracheal tube is used for patient airway management and provides a means to conveniently irrigate and drain the subglottic region below the vocal co ...


6
Stuart K Williams, Bruce E Jarrell: Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself. Thomas Jefferson University, Woodcock Washburn Kurtz Mackiewicz & Norris, April 11, 1989: US04820626 (162 worldwide citation)

The present invention provides a novel method of treating a synthetic or naturally occurring implant, such as a vascular graft, intended for implantation in a human patient, comprising obtaining human microvascular rich tissue from that patient; separating microvascular endothelial cells from that t ...


7
Jewell L Osterholm: Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders. Thomas Jefferson University, Woodcock Washburn Kurtz Mackiewicz & Norris, May 1, 1984: US04445500 (135 worldwide citation)

A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqu ...


8
Paul Walinsky, Peter A Lewin, John M Reid: Intravascular, ultrasonic imaging catheters and methods for making same. Thomas Jefferson University, Drexel University, Woodcock Washburn Kurtz Mackiewicz & Norris, August 31, 1993: US05240004 (121 worldwide citation)

Novel intravascular, ultrasonic imaging catheters are provided which utilize thin layers of a flexible plastic material, such as PVDF, which can be spot polarized in active regions which are to serve as piezoelectric transducers. Thin layer metallic electrodes are deposited on opposing surfaces of t ...


9
Darwin J Prockop, Ruth F Pereira, Dennis B Leeper, Michael D O Hara: Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects. Thomas Jefferson University, Woodcock Washburn Kurtz Mackiewicz & Norris, February 10, 1998: US05716616 (119 worldwide citation)

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration ...


10
Stuart K Williams, Bruce E Jarrell: Method of treating a synthetic naturally occurring surface with a collagen laminate to support microvascular endothelial cell growth, and the surface itself. Thomas Jefferson University, Woodcock Washburn Kurtz Mackiewicz & Norris, July 21, 1992: US05131907 (117 worldwide citation)

A novel implantable prosthesis for implantation in human patients is disclosed which comprises a synthetic substrate and a Type IV/V collagen surface layer seeded with a confluent monolayer of autologous endothelial cells. In the preferred embodiment, a base layer of interstitial collagen is adhered ...