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Narr Berthold Dr Dipl Chem, Bomhard Andreas Dr Dipl Chem, Hauel Norbert Dr Dipl Chem, Van Meel Jacques Dr, Wienen Wolfgang Dr Dipl Biol, Entzeroth Michael Dr Dipl Chem: Benzimidazoles, drugs containing these compounds and process for their preparation.. Thomae Dr K, October 17, 1990: EP0392317-A2 (78 worldwide citation)

The invention relates to benzimidazoles of the formula in which R1 to R6 are defined as in claim 1, their 1- and 3-isomer mixtures and their acid addition salts, which have useful properties. The novel compounds are in particular angiotensin II antagonists.


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Himmelsbach Frank Dr, Austel Volkhard Dr, Pieper Helmut Dr, Linz Guenter Dr, Weisenberger Johannes Dr, Mueller Thomas Dr: Cyclic imino derivatives, medicaments containing these compounds and processes for the production thereof.. Thomae Dr K, November 3, 1993: EP0567966-A1 (57 worldwide citation)

The invention relates to cyclic imino derivatives of the general formula B-X2-X1-A-Y-E ,(I> in which A, B, E, X1, X2 and Y are as defined in Claim 1, stereoisomers thereof, tautomers thereof, mixtures thereof and salts thereof, in particular physiologically tolerable salts thereof with inorganic or ...


3
Nickl Josef Dr Dipl Chem, Haarmann Walter Dr, Ballhause Helmut, Weisenberger Johannes Dr Dipl, Heckel Armin Dr Dipl Chem, Mueller Erich Dr Dipl Chem, Narr Berthold Dr Dipl Chem: Sulfonylaminoethyl compounds, medicines containing these compounds and process for their preparation.. Thomae Dr K, September 17, 1986: EP0194548-A2 (46 worldwide citation)

Sulphonylaminoethyl compounds of the formula in which R1 denotes a phenyl group which is optionally mono- or disubstituted by a methyl group or a halogen atom, where the substituents can be identical or different, a biphenylyl group which is optionally substituted by a halogen atom, or a naphthyl, p ...


4
Hauel Norbert Dr Dipl Chem, Narr Berthold Dr Dipl Chem, Ries Uwe Dr Dipl Chem, Van Meel Jacques Dr, Wienen Wolfgang Dr Dipl Biol, Entzeroth Michael Dr Dipl Chem: Benzimidazol, medicaments containing them and process for their preparation.. Thomae Dr K, September 9, 1992: EP0502314-A1 (45 worldwide citation)

The invention relates to benzimidazoles of the general formula in which R1 to R4 are as defined in Claim 1, mixtures of the 1 and 3 isomers thereof, and the salts thereof, which have valuable properties. The compounds are, in particular, angiotensin antagonists.


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Griss Gerhart Dr Dipl Chem, Schneider Claus Dr Dipl Chem, Hurnaus Rudolf Dr Dipl Chem, Kobinger Walter Prof Dr, Pichler Ludwig Dr, Bauer Rudolf Dr, Mierau Joachim Dr, Hinzen Dieter Prof Dr, Schingnitz Gunter Dr: Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs.. Thomae Dr K, July 2, 1986: EP0186087-A1 (44 worldwide citation)

Gegenstand der vorliegenden Erfindung sind neue Tetrahydrobenzthiazole der allgemeinen Formel in der R1 ein Wasserstoffatom, eine Alkylgruppe, eine Alkenyloder Alkinylgruppe, eine Alkanoylgruppe, eine Phenylalkyloder Phenylalkanoylgruppe, wobei die oben erwähnten Phenylkerne jeweils durch 1 oder 2 H ...


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Himmelsbach Frank Dr Dipl Chem, Austel Volkhard Dr Dipl Chem, Pieper Helmut Dr Dipl Chem, Eisert Wolfgang Prof Dr Dr Dr, Mueller Thomas Dr Dipl Chem, Weisenberger Johannes Dr Dipl, Linz Guenter Dr Dipl Chem, Krueger Gerd Dr Dipl Chem: Cyclic imino derivatives, process for their preparation and drugs containing them.. Thomae Dr K, May 6, 1992: EP0483667-A2 (43 worldwide citation)

The invention relates to cyclic imino derivatives of the general formula B - X - A - Y - E (I> in which A, B, E, X and Y are as defined in Claim 1, their geometrical isomers and their addition salts, in particular their physiologically tolerable addition salts with inorganic or organic acids or base ...


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Derivatives of pyrimido[5,4-d] pyrimidine and production thereof. Thomae Dr K, January 21, 1959: GB807826-A (39 worldwide citation)

The invention comprises pyrimido [5,4-d] pyrimidines substituted in at least one of the 2-, 4-, 6- and 8-positions by one or more of the following atoms or groups: halogen (e.g. Cl, Br, I), amino, mono- or di-substituted amino (e.g. mono- or di-alkyl- or -aryl-amino), ether (e.g. alkoxy, aryloxy), t ...


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Bomhard Andreas Dr Dipl Chem, Psiorz Manfred Dr Dipl Chem, Heider Joachim Dr Dipl Chem, Hauel Norbert Dr Dipl Chem, Noll Klaus Dr Dipl Chem, Narr Berthold Dr Dipl Chem, Kobinger Walter Prof Dr, Lillie Christian Dr: Heteroaromatic amine derivatives, medicaments containing them and process for their preparation.. Thomae Dr K, December 10, 1986: EP0204349-A2 (33 worldwide citation)

Die vorliegende Erfindung betrifft neue heteroaromatische Aminderivate der allgemeinen Formel in der A eine -CH2-CH2-, -CH=CH- oder -C?2-CO-Gruppe und B eine Methylen-, Carbonyl- oder Thiocarbonylgruppe oder und B eine Methylengruppe, wobei das mit x gekennzeichnete Kohlenstoffatom jeweils mit dem P ...


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Substituted dibenz[b,f][1,4]oxazepin-11(10h)-ones. Thomae Dr K, November 12, 1969: GB1170322-A (33 worldwide citation)

1,170,322. Sedative &c. compositions. DR. KARL THOMAE G.m.b.H. 27 Jan., 1967 [28 Jan., 1966], No. 4283/67. Heading A5B. [Also in Division C2] Pharmaceutical compositions, suitable for oral, parenteral or rectal administration comprise as active ingredient at least one novel compound and/or at least ...