1
Arthur M Krieg, Dennis Klinman, Alfred D Steinberg: Immunomodulatory oligonucleotides. The University of Iowa Research Foundation, The United States of America, Coley Pharmaceutical Group, Wolf Greenfield & Sacks P C, February 27, 2001: US06194388 (238 worldwide citation)

Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinuc ...


2
Matthew A Howard III: Stereotactic hypothalamic obesity probe. The University of Iowa Research Foundation, Fleshner & Kim, October 10, 2000: US06129685 (195 worldwide citation)

Apparatus and methods for regulating the appetite of an individual suffering from morbid obesity, the apparatus including a plurality of stimulation electrodes arranged longitudinally on at least one electrode support shaft for insertion within the hypothalamus for outputting electrical discharges t ...


3
Matthew A Howard III: Wireless prosthetic electrode for the brain. The University of Iowa Research Foundation, Fleshner & Kim, September 1, 1998: US05800535 (195 worldwide citation)

A wireless neural prosthetic device for a primary auditory cortex of a patient includes either a speech processor or a stimulating device for receiving and processing information and a wireless electrode arranged in the primary auditory cortex having a plurality of electrical contacts. The electrode ...


4
Matthew A Howard III, Timothy M McCulloch, Carol A Bauer: Human drug delivery device for tinnitus. The University of Iowa Research Foundation, Fleshner & Kim, February 3, 1998: US05713847 (152 worldwide citation)

A neural prosthetic drug delivery apparatus for reducing or eliminating the effects of tinnitus. The apparatus includes a catheter which is inserted into the patient's auditory cortex or thalamus. The catheter microinfuses drugs which suppress or eliminate abnormal neural activity into geometrically ...


5
Douglas H Jones: Iterative and regenerative DNA sequencing method. The University of Iowa Research Foundation, Elizabeth A Hanley, Lahive & Cockfield, January 12, 1999: US05858671 (114 worldwide citation)

An iterative and regenerative method for sequencing DNA is described. This method sequences DNA in discrete intervals starting at one end of a double stranded DNA segment. This method overcomes problems inherent in other sequencing methods, including the need for gel resolution of DNA fragments and ...


6
Balkrishna Ramkumar, Volker Strumpen: System and method for providing checkpointing with precompile directives and supporting software to produce checkpoints, independent of environment constraints. The University of Iowa Research Foundation, Fleshner & Kim, December 12, 2000: US06161219 (101 worldwide citation)

A method for portable checkpointing comprising the steps of: pre-compiling an input source code; and outputting an associated output source code which includes support for portable checkpointing. The portability of the checkpoints allows migration between systems with different hardware, software, a ...


7
Renuka Uppaluri, Theophano Mitsa, Eric A Hoffman, Geoffrey McLennan, Milan Sonka: Method and apparatus for analyzing CT images to determine the presence of pulmonary tissue pathology. The University of Iowa Research Foundation, Fulbright & Jaworski L, October 15, 2002: US06466687 (95 worldwide citation)

A method and apparatus for analyzing CT images to determine the presence of pulmonary tissue pathology, such as in emphysema, IPF, sarcoid, etc. In accordance with one embodiment, a CT slice is selected to perform an automated, objective, and quantitative analysis of the slice. Initially, an image p ...


8
Joon B Park, Vijay K Goel, Malcolm H Pope, James N Weinstein: Surgically implantable fastening system. The University of Iowa Research Foundation, Arnold White & Durkee, December 21, 1999: US06004323 (94 worldwide citation)

The present invention discloses a nut to be used in a spinal screw and plate assembly to affix the screw and plate assembly to the spinal bone. The nut has a polymer insert that when contacted with a screw allows a bone plate and screw structure to relax over time.


9
Jay T Rubinstein, Carolyn J Brown, Richard S Tyler, Paul J Abbas: Pseudospontaneous neural stimulation system and method. The University of Iowa Research Foundation, Fleshner & Kim, September 25, 2001: US06295472 (92 worldwide citation)

A system and method for application of pseudospontaneous neural stimulation is provided that can generate stochastic independent activity across an excited nerve or neural population without an additional disadvantageous sensations. High rate pulse trains, for example, can produce random spike patte ...


10
Balkrishna Ramkumar, Volker Strmupen: Method and apparatus for portable checkpointing using data structure metrics and conversion functions. The University of Iowa Research Foundation, Fleshner & Kim, November 28, 2000: US06154877 (91 worldwide citation)

A method and apparatus for portable checkpointing comprising the steps of: pre-compiling an input application source code and basic data type conversion functions; and outputting an associated output application source code and structure metrics and conversion function source code, wherein the outpu ...