1
David M Segal, Pilar Perez: Target specific cross-linked heteroantibodies. The United States of America represented by the Secretary of the Department of Health and Human Services, Holman & Stern, June 30, 1987: US04676980 (652 worldwide citation)

The present invention discloses a target specific cross-linked heteroantibody and a method of producing the same. The cross-linked heteroantibodies of the present invention can cause normal autologous cells of the immune system to destroy any unwanted cell for which an antibody is available. Treatme ...


2
Mary E Hawkins, Wolfgang Pfleiderer, Michael D Davis, Frank Balis: Pteridine nucleotide analogs as fluorescent DNA probes. The United States of America represented by the Secretary of the Department of Health and Human Services, Townsend and Townsend and Crew, June 11, 1996: US05525711 (247 worldwide citation)

The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides ...


3
Robert C Gallo, Mikulas Popovic, Mangalasseril G Sarngadharan: Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions. The United States of America represented by the Secretary of the Department of Health and Human Services, John S Roberts Jr, May 28, 1985: US04520113 (159 worldwide citation)

This invention relates to the detection of antibodies in sera of AIDS and pre-AIDS patients and describes the biochemical and immunological analysis of antigens associated with the virus HTLV-III Human T-Cell Leukemia Virus. It is shown that antigens associated with the infection of human cells by t ...


4
Hynda K Kleinman, George R Martin: Reconstituted basement membrane complex with biological activity. The United States of America represented by the Secretary of the Department of Health and Human Services, Holmn & Stern, May 9, 1989: US04829000 (142 worldwide citation)

The present invention discloses a biologically active basement membrane composition. When polymerized under physiological conditions, the composition forms gel-like structures whose ultrastructure resembles interconnected thin sheets of the lamina densa zone of basement membrane. The major component ...


5
Miguel F Refojo, Hsaio S Liu: Method for treating intraocular malignancies. The United States of America represented by the Secretary of the Department of Health and Human Services, John S Roberts Jr, November 17, 1981: US04300557 (123 worldwide citation)

An improved process for dispensing a lipid soluble labile drug, i.e. 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) by diffusion through a silicone capsule implanted at a periocular site to an intraocular site within an animal body being treated with the drug, the improvements wherein the silicone cap ...


6
Howard Bassen, Victor Krauthamer: Apparatus and method for in situ detection of areas of cardiac electrical activity. The United States of America represented by the Secretary of the Department of Health and Human Services, Guy W Chambers, Townsend and Townsend and Crew and, October 21, 1997: US05678550 (122 worldwide citation)

An apparatus and method for detecting electrical activity in areas of tissue. The apparatus (1) includes a main catheter (5), multifibered endoscope (10), light filtering means (30, 42, 52), photodetectors (40, 50) and a signal processor (60). The apparatus is used to detect electrical activity by f ...


7
Larry K Keefer, Joseph A Hrabie: Complexes of nitric oxide with polyamines. The United States of America represented by the Secretary of the Department of Health and Human Services, Birch Stewart Kolasch & Birch, October 13, 1992: US05155137 (95 worldwide citation)

There are disclosed novel complexes of nitric oxide and polyamines which are useful in treating cardiovascular disorders, including hypertension. The disclosed compounds release nitric oxide (endothelium-derived relaxing factor) under physiological conditions in a sustained and controllable fashion, ...


8
B Rao Vishnuvajjala, Aaron Garzon Aburbeh: Water soluble prodrugs of camptothecin. The United States of America represented by the Secretary of the Department of Health and Human Services, John Bailey, Robert Benson, July 24, 1990: US04943579 (90 worldwide citation)

Water-soluble derivatives of camptothecin have the formulae: ##STR1## wherein R' is selected from the group consisting of R=CO CH.sub.2 NH.sub.2.HCl


9
Rong Fu Wang, Steven A Rosenberg: Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein. The United States of America represented by the Secretary of the Department of Health and Human Services, Morgan & Finnegan L, November 24, 1998: US05840839 (89 worldwide citation)

The present invention discloses that the normal melanogenic gene, gp75 gene, encodes a gene product, a 24 amino acid peptide of ORF3, which is processed to an antigenic cancer peptide recognized by T lymphocytes. The cancer peptide of the invention derived from ORF3 is recognized by cancer antigen s ...


10
Seth R Goldstein: Confocal scanning laser microscope having no moving parts. The United States of America represented by the Secretary of the Department of Health and Human Services, Holman & Stern, May 2, 1989: US04827125 (88 worldwide citation)

A confocal scanning laser microscope has no moving parts and displays real time video images. The image of the scanned laser spot on the specimen is focused on the photocathode of an image dissector tube having an electron image deflection that is synchronized and aligned with the laser scan. This p ...