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Peter Wilding, Larry J Kricka: Mesoscale polynucleotide amplification devices. The Trustees of the University of Pennsylvania, Dann Dorfman Herrell and Skillman, December 24, 1996: US05587128 (611 worldwide citation)

Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide amplification reaction. The devices are provided with a substrate microfabricated to include a polynucleotide amplification reaction chamber, having at least one cross-sectional dimension of ...


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Peter Wilding, Larry J Kricka, Jay N Zemel: Apparatus for the detection of an analyte utilizing mesoscale flow systems. The Trustees Of The University Of Pennsylvania, Dann Dorfman Herrell and Skillman P C, February 2, 1999: US05866345 (272 worldwide citation)

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system furthe ...


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Garrett Derbyshire: Expandable transluminally implantable tubular prosthesis. The Trustees of the University of Pennsylvania, Woodcock Washburn Kurtz Mackiewicz & Norris, April 16, 1991: US05007926 (232 worldwide citation)

Improved expandable tubular prostheses and methods for their use are provided by this invention. The prostheses include a resilient member having longitudinal sides and transverse ends and are disposed in a tubular configuration about a transverse axis. The resilient member comprises ratcheting mean ...


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John Q Trojanowski, Virginia M Y Lee: Modified avidin-biotin technique. The Trustees of The University of Pennsylvania, Woodcock Washburn Kurtz Mackiewicz & Norris, January 25, 1994: US05281521 (211 worldwide citation)

A method for preparing an antigen specific probe is provided by incubating a primary antigen specific monoclonal antibody with a biotinylated secondary antibody to produce a complex of the primary and secondary antibodies. The staining pattern produced by these probes reflects the specificity of the ...


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Paul J Ratnaraj, William Gerard McCartney, Son To, Steven J Crispi, Jalal D Akhavein: Authenticated access to internet based research and data services. The Trustees of the University of Pennsylvania, Woodcock Washburn Kurtz Mackiewcz & Norris, February 6, 2001: US06185567 (183 worldwide citation)

Access to a database is provided via the Internet using a World Wide Web server including a search engine, a CGI gateway and user selectable data queries for extracting data, generating reports, and the like. Access by the user is authenticated by querying the user's central machine for authent ...


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Jason K Otto, Brian McKinnon, Dean Hughes, Michael Ries, Jan Victor, Johan Bellemans, Johanthan Garino, Timothy Wilton: High performance knee prostheses. Smith & Nephew, The Trustees of the University of Pennsylvania, Kilpatrick Stockton, February 5, 2008: US07326252 (169 worldwide citation)

Knee prostheses featuring components that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or at least accommodating internal tibial rotation in a controlled way, rep ...


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Peter Wilding, Larry J Kricka, Jay N Zemel: Device and method for the detection of an analyte utilizing mesoscale flow systems. The Trustees of the University of Pennsylvania, Dann Dorfman Herrell and Skillman P C, April 22, 2003: US06551841 (165 worldwide citation)

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system furthe ...


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David B Weiner, William V Williams, Bin Wang: Genetic immunization. The Wistar Institute, The Trustees of the University of Pennsylvania, Woodcock Washburn Kurtz Mackiewicz & Norris, January 14, 1997: US05593972 (157 worldwide citation)

Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises ...


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Rosana Esteller, Javier Ramón Echauz, Brian Litt, George John Vachtsevanos: Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control. The Trustees of the University of Pennsylvania, Womble Carlyle Sandridge & Rice PLLC, July 15, 2003: US06594524 (149 worldwide citation)

A method and apparatus for forecasting and controlling neurological abnormalities in humans such as seizures or other brain disturbances. The system is based on a multi-level control strategy. Using as inputs one or more types of physiological measures such as brain electrical, chemical or magnetic ...