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Michael M Harpold, Paul Brust: Assay methods and compositions useful for measuring the transduction of an intracellular signal. The Salk Institute Biotechnology Industrial Associates, Brown Martin Haller & McClain, March 28, 1995: US05401629 (102 worldwide citation)

Recombinant cells are provided which are useful for assaying compounds for their agonist or antagonist activity with respect to ion channels and/or cell surface-localized receptors. In addition, assay methods employing the invention recombinant cells are provided.


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Gregory C Holtz, Russell A Brierley: Method for the purification of intact, correctly-folded insulin-like growth factor-1. The Salk Institute Biotechnology Industrial Associates, Fitch Even Tabin & Flannery, July 27, 1993: US05231178 (85 worldwide citation)

Method for the recovery and purification of intact, correctly-folded, monomeric insulin-like growth factor-1 peptide from large volumes of IGF-1-containing medium are described, comprising a series of adsorption-desorption steps employing a combination of cation exchange and hydrophobic interaction ...


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Michael M Harpold, Steven B Ellis: DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same. The Salk Institute Biotechnology Industrial Associates, Pretty Schroeder Brueggemann & Clark, November 29, 1994: US05369028 (15 worldwide citation)

Human neuronal nicotinic acetylcholine receptor subunits are described, as are methods for producing cells containing functional receptors employing such subunits. Also described are assay methods for determining the presence of functional HnAChRs in transfected cells, and for determining the agonis ...


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Thomas S Vedvick, Michael E Engel, Mary S Urcan, Richard G Buckholz, Jennifer A Kinney: DNA for expression of aprotinin in methylotrophic yeast cells. The Salk Institute Biotechnology Industrial Associates, Fitch Even Tabin & Flannery, November 2, 1993: US05258302 (8 worldwide citation)

Biologically active aprotinin (APR) molecules, naturally occurring, relatively short, single chain polypeptides, are prepared by growing methylotrophic yeast transformants containing in their genome at least one copy of a DNA sequence operably encoding APR, in operational association with a DNA sequ ...


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Steven B Ellis, Michael M Harpold: Nucleic acid probes for prenatal sexing. The Salk Institute Biotechnology Industrial Associates, Fitch Even Tabin & Flannery, October 2, 1990: US04960690 (8 worldwide citation)

Nucleic acid hybridizaiton probes are provided which have sequences complementary to sequences of segments in bovine male-specific DNA and are suitable for sexing bovine embryos at the time of embryo transfer with nearly 100% accuracy.