1
Harold A Nash, Daniel R Mishell Jr: The Population Council, Brumbaugh Graves Donohue & Raymond, October 6, 1981: US04292965 (110 worldwide citation)

This invention relates to an improved intravaginal ring for use as a contraceptive comprising an inert elastomer core, a medicated layer encircling the core and an outer inert elastomer layer and method of manufacturing the intravaginal ring.


2
Saleh Ismail Saleh, Harold A Nash, C Wayne Bardin, Troy Harmon: The Population Council, Lerner David Littenberg Krumholz & Mentlik, October 26, 1999: US05972372 (64 worldwide citation)

Disclosed is a vaginal ring intended for the release of at least one drug over a prolonged time period. The vaginal ring contains a ring body made of a first polymeric material having at least one hollow internal channel defining an opening to the exterior of the ring body and which channel is adapt ...


3
Gopi N Gupta: Manufacture of long term contraceptive implant. The Population Council, Brumbaugh Graves Donohue & Raymond, January 13, 1981: US04244949 (34 worldwide citation)

This invention relates to a bioabsorbable fused implant for subcutaneous administration in mammals of a constant and effective amount of a steroid over a prolonged period comprising a solid dispersion of an effective amount of a steriod uniformly dispersed in a matrix of a lipoid carrier the weight ...


4
Tapani Luukkainen, Ahti M K Liukkonen: Medicated intracervical and intrauterine devices. The Population Council, Brumbaugh Graves Donohue & Raymond, March 25, 1986: US04578076 (30 worldwide citation)

This invention relates to a medicated device for insertion into the uterus or cervix comprising a T-shaped platform and a drug release attachment thereon, the platform having a vertical stem portion with a rounded knob portion at the top thereof and two flat flexible downwardly slanting arms extendi ...


5
Saleh Ismail Saleh, Harold A Nash, C Wayne Bardin, Troy Harmon: The Population Council, Lerner David Littenberg Krumholz & Mentlik, October 3, 2000: US06126958 (29 worldwide citation)

Disclosed is a vaginal ring intended for the release of at least one drug over a prolonged time period. The vaginal ring contains a ring body made of a first polymeric material having at least one hollow internal channel defining an opening to the exterior of said body and which channel is adapted t ...


6
Alfred Joseph Moo Young: Subdermally implantable device. The Population Council Center for Biomedical Research, Lerner David Littenberg Krumholz & Mentlik, August 26, 1997: US05660848 (28 worldwide citation)

Disclosed is a subdermally implantable drug-delivery device, which contains: a central core extending in an axial direction and having an outer surface and opposing ends, which core includes a matrix of a pharmaceutically effective amount of a subdermally administrable drug substantially uniformly d ...


7
Dale N Robertson, John Braun: Method for making an IUD with shrinking of a medicated attachment onto a support. The Population Council, Brumbaugh Graves Donohue & Raymond, July 27, 1982: US04341728 (19 worldwide citation)

Method for making a medicated IUD including a preexisting contraceptive intrauterine platform and an attachment formed as a cylindrical sleeve of base polymer containing a drug such as an antifertility agent. Local controlled release administration of the drug is added to the contraceptive effect of ...


8
Theodore Jackanicz, Horacio B Croxatto Avoni, Leopoldo Glasser Drexler, Fernando Zegers Hochschild: The Population Council, Lerner David Littenberg Krumholz & Mentlik, February 9, 1999: US05869081 (18 worldwide citation)

The present invention relates to a method of administering progesterone to a normogonadal or a functionally agonadal human female undergoing an assisted reproduction technique. The invention further provides a method of hormone replacement for a human female. In a preferred embodiment of the present ...


9
Alfred Moo Young, Ana Zepeda Ortega, Horacio Bruno Croxatto: Therapeutically effective topical application of ST1435. The Population Council, Brumbaugh Graves Donohue & Raymond, July 29, 1997: US05651973 (17 worldwide citation)

The progesterone analog ST1435 has now been found to attain therapeutically effective levels upon topical application to the skin. ST1435 can be administered topically either in liquid or semisolid base such as a cream or gel or in a solid base such as a transdermal device such as a disk, band patch ...


10
Sitruk Ware Regine, Tsong Yun Yen: Sustained release compositions containing progesterone receptor modulators. The Population Council, Laboratoire Hra Pharma, Sitruk Ware Regine, Tsong Yun Yen, FOLEY Shawn P, January 26, 2006: WO/2006/010097 (13 worldwide citation)

Disclosed are sustained release compositions for vaginal or transdermal administration that contain a progesterone receptor modulator such as CDB-2914 (also referred to as VA-2914), and methods of using them for long term contraception or therapeutic purposes. Also disclosed are methods for making t ...