1
Kary B Mullis, Larry Johnson, Richard A Leath, Timothy J Wennberg, Louis M Mezei, Joseph T Widunas: System for automated performance of the polymerase chain reaction. The Perkin Elmer Corporation, William J Hone, Richard P Ferrara, August 12, 1997: US05656493 (279 worldwide citation)

There is disclosed herein a machine for performing nucleic acid amplification under computer control. The machine utilizes any one of a number of heating and cooling systems under control of a host computer which directs the heating and cooling systems to heat and cool a reaction-chamber-containing ...


2
Lawrence A Haff, Enrico Picozza, Will Bloch, Robert Ragusa, Joseph DiCesare, David Tracy, Paul Saviano, Timothy M Woudenberg: Nucleic acid amplification reaction apparatus. The Perkin Elmer Corporation, Edwin T Grimes, David Aker, February 24, 1998: US05720923 (235 worldwide citation)

Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through t ...


3
John G Atwood, Albert C Mossa, Lisa M Goven, Fenton Williams, Timothy M Woudenberg, Marcel Margoulies, Robert P Ragusa, Richard Leath, Clive Miles: Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control. The Perkin Elmer Corporation, Davis Hoxie Faithfull & Hapgood, December 12, 1995: US05475610 (231 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


4
Timothy M Woudenberg, Kevin S Bodner, Charles R Connell, Alan M Ganz, Lincoln J McBride, Paul G Saviano, John Shigeura, David H Tracy, Eugene F Young, Linda G Lee: System for real time detection of nucleic acid amplification products. The Perkin Elmer Corporation Applied Biosystems Division, Wilson Sonsini Goodrich & Rosati, July 27, 1999: US05928907 (180 worldwide citation)

A system is provided for carrying out real time fluorescence-based measurements of nucleic acid amplification products. In a preferred embodiment of the invention, an excitation beam is focused into a reaction mixture through a surface, the reaction mixture containing (i) a first fluorescent indicat ...


5
Linda G Lee, Sandra L Spurgeon, Barnett Rosenblum: Energy transfer dyes with enchanced fluorescence. The Perkin Elmer Corporation, Wilson Sonsini Goodrich & Rosati, September 1, 1998: US05800996 (179 worldwide citation)

Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an ener ...


6
Lawrence A Haff, Enrico Picozza, Will Bloch, Robert Ragusa, Joseph DiCesare, David Tracy, Paul Saviano, Timothy M Woudenberg, Richard W Noreiks: Nucleic acid amplification reaction apparatus and method. The Perkin Elmer Corporation, Perman & Green, March 7, 2000: US06033880 (175 worldwide citation)

Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through t ...


7
Scott Conrad Benson, Steven Michael Menchen, Peter David Theisen, Krishna Gajanan Upadhya, Joan Dale Hauser: Aromatic-substituted xanthene dyes. The Perkin Elmer Corporation, Paul D Grossman, Alex Andrus, Ann M Cavini Pease, December 28, 1999: US06008379 (173 worldwide citation)

A class of aromatic-substituted xanthene compounds useful as fluorescent dyes is disclosed, the compounds having the general structure where Y.sub.1 and Y.sub.2 taken separately are selected from the group consisting of hydroxyl, oxygen, imminium, linking group and amine, or Y.sub.1 taken together w ...


8
Offner Abe: Unit power imaging catoptric anastigmat. The Perkin Elmer Corporation, July 24, 1973: US3748015 (154 worldwide citation)

A catoptric system for forming in accurate micro detail an image of an object at unit magnification with high resolution is provided by convex and concave spherical mirrors arranged with their centers of curvature coinciding at a single point. The mirrors are arranged to produce at least three refle ...


9
Harvey R Sellner, Robert T Wada: Currency discriminator. The Perkin Elmer Corporation, Giarratana, E T Grimes, T P Murphy, September 8, 1981: US04288781 (151 worldwide citation)

A currency discriminator for determining the denomination of a bank note or the like is disclosed. It includes a source of light directed at the note to be identified. A 2 mm.times.80 mm stripe is illuminated and the reflected light from the illuminated area is measured by a detector and converted i ...


10
Linda Lee, Scott C Benson, Barnett B Rosenblum, Sandra L Spurgeon: 4, 7-Dichlororhodamine dyes. The Perkin Elmer Corporation, Paul D Grossman, December 8, 1998: US05847162 (150 worldwide citation)

A class of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein R.sub.1 -R.sub.6 are hydrogen, fluorine, chlorine, lower alkyl lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, lining group, or combinations ...



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