1
Edgar Haber: Composition and method for determining the size and location of myocardial infarcts. The Massachusetts General Hospital, July 19, 1977: US04036945 (192 worldwide citation)

Radioactive labelled antibody for cardiac myosin is injected intravenously after cardiac occlusion and is specifically absorbed in infarcted myocardium, as are radioactive labelled lower molecular weight fragments of the antibody such as (Fab').sub.2, (Fab'), and (Fv). The location and size of the m ...


2
Edgar Haber, Ban A Khaw: Radiolabeled diagnostic compositions and method for making the same. The Massachusetts General Hospital, Paul J Cook, December 20, 1983: US04421735 (63 worldwide citation)

Protein molecules are covalently bonded to a chelating agent which in turn binds a radioactive molecule. Prior to binding, the radioactive molecule is reduced with dithionite ion and then mixed with protein at a pH of 7.0 to about 8.0.


3
Jack R Wands, Vincent R Zurawski Jr: Process for producing antibodies to hepatitis virus and cell lines therefor. The Massachusetts General Hospital, Saidman Sterne & Kessler, January 1, 1985: US04491632 (55 worldwide citation)

Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce monoclonal antibo ...


4
Paul H Ehrlich, Gary R Matsueda, Michael N Margolies, Edgar Haber: Antibody fragment compositions and process. The Massachusetts General Hospital, October 19, 1982: US04355023 (54 worldwide citation)

Immunologically active rabbit IgG antibody fragment compositions are produced by isolating the anti-light variable chain of rabbit IgG and/or the anti-heavy variable chain of rabbit IgG and combining them with each other or with the complementary heavy or light chain of rabbit IgG.


5
Jack R Wands, Vincent R Zurawski Jr: Process for producing antibodies to hepatitis virus and cell lines therefor. The Massachusetts General Hospital, Paul J Cook, Marvin C Guthrie, June 2, 1981: US04271145 (50 worldwide citation)

Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce monoclonal antibo ...


6
David M Young: Process for healing wounds. The Massachusetts General Hospital, Paul J Cook, Marvin C Guthrie, September 1, 1981: US04287184 (38 worldwide citation)

Healing of a wound is accelerated by administering a new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions. The nerve growth factor is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland ...


7
Harry W Strauss, Ronald J Callahan, Jerry W Froelich: Apparatus for radiolabeling red blood cells. The Massachusetts General Hospital, Paul J Cook, September 18, 1984: US04471765 (34 worldwide citation)

A method and apparatus for radiolabeling red blood cells is provided which includes a syringe holder, a vial containing heparin, a vial containing technetium-99m and a catheter. The vials and catheter are connected to channels within the syringe holder and a valve positioned at the intersection of t ...


8
David M Young: Nerve growth factor antibody and process. The Massachusetts General Hospital, Thompson Birch Gauthier & Samuel, October 28, 1980: US04230691 (22 worldwide citation)

An antibody is prepared from a stable new form of nerve growth factor having a molecular weight of about 116,000. The pure nerve growth factor is obtained from an extract of mouse submandibular gland or mouse saliva which is subjected to ion-exchange chromatography to recover a component of the glan ...


9
Charles A Burnham, John F Bradshaw Jr, David E Kaufman, David A Chesler, Gordon L Brownell: Positron source position sensing detector and electronics. The Massachusetts General Hospital, Weingarten Schurgin Gagnebin & Hayes, July 23, 1985: US04531058 (21 worldwide citation)

A positron source, position sensing device, particularly with medical applications, in which positron induced gamma radiation is detected using a ring of stacked, individual scintillation crystals, a plurality of photodetectors, separated from the scintillation crystals by a light guide, and high re ...


10
Charles J Homcy, Edgar Haber: Assay for beta-adrenergic antagonists and antibody therefor. The Massachusetts General Hospital, Paul J Cook, Marvin C Guthrie, June 1, 1982: US04332787 (20 worldwide citation)

Body fluids are assayed for aryloxypropylamine beta-adrenergic antagonists and/or their active metabolites by agglutination reaction with antibody for the antagonist and/or active metabolite. The antibody is produced from an antigen comprising a conjugate of an immunogenic protein linked by a diazo ...