1
Robert P Lenk, Michael W Fountain, Andrew S Janoff, Marc J Ostro, Micrea C Popescu: Stable plurilamellar vesicles, their preparation and use. The Liposome Company, Pennie & Edmonds, June 11, 1985: US04522803 (204 worldwide citation)

A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.


2
Mircea C Popescu, Alan L Weiner, Sharon S Carpenter Green: Liposome-gel compositions. The Liposome Company, Pennie & Edmonds, November 24, 1987: US04708861 (160 worldwide citation)

Compositions and methods for maintaining reservoirs of bioactive agents by sequestering the reservoir in a gel matrix are described. In particular, liposomes containing an entrapped bioactive agent are sequestered in a gel matrix. The resulting liposome-gel compositions may be used in vivo or in vit ...


3
Pieter R Cullis, Michael J Hope, Marcel B Bally: Extrusion technique for producing unilamellar vesicles. The Liposome Company, Allen Bloom, Catherine Kurtz, Ronald G Ort, April 16, 1991: US05008050 (160 worldwide citation)

A method for reducing the lamellarity of a population of liposomes is provided which comprises repeatedly passing the liposomes under pressure through a filter which has a pore size equal to or less than about 100 nm. In certain embodiments, the method is used to convert a population of previously f ...


4
Michael W Fountain, Steven J Weiss, John J Kearns, Alan L Weiner, Mircea C Popescu: Lipid matrix carriers for use in drug delivery systems. The Liposome Company, Pennie & Edmonds, September 9, 1986: US04610868 (142 worldwide citation)

Lipid matrix carriers are described which provide for the sustained release of bioactive agents in vivo or in vitro. The properties of the lipid matrix carriers of the present invention include high entrapment efficiencies; release of entrapped compounds in their active form; biodegradability and av ...


5
Michael W Fountain, Steven J Weiss, Mircea C Popescu: Lipid vesicles prepared in a monophase. The Liposome Company, Pennie & Edmonds, May 13, 1986: US04588578 (132 worldwide citation)

A process for the preparation in a monophasic solvent system of a new type of lipid vesicles, called monophasic lipid vesicles (MPVs). MPVs can be made to encapsulate one or more bioactive agents. MPVs are stable during storage and can be used in vivo in the treatment of disease.


6
Marcel B Bally, Pieter R Cullis, Michael J Hope, Thomas D Madden, Lawrence D Mayer: Encapsulation of antineoplastic agents in liposomes. The Liposome Company, Allen Bloom, Catherine L Kurtz, December 31, 1991: US05077056 (122 worldwide citation)

Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials are provided. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplast ...


7
Michael J Hope, Pieter R Cullis: Induction of asymmetry in vesicles. The Liposome Company, Allen Bloom, Catherine L Kurtz, April 20, 1993: US05204112 (105 worldwide citation)

Methods are described for controlling the transbilayer distribution of ionizable lipids and proteins in vesicles. Control of the ion gradient of the exterior bathing medium in relation to that of the interior entrapped aqueous compartment of the vesicles induces migration of ionizable lipids or prot ...


8
Andrew S Janoff, Pieter R Cullis, Marcel B Bally, Michael W Fountain, Richard S Ginsberg, Michael J Hope, Thomas D Madden, Hugh P Schieren, Regina L Jablonski: Dehydrated liposomes. The Liposome Company, Allen Bloom, Catherine L Kurtz, November 14, 1989: US04880635 (98 worldwide citation)

Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. F ...


9
Andrew S Janoff, Mircea C Popescu, Alan L Weiner, Lois E Bolcsak, Paul S Tremblay: Steroidal liposomes. The Liposome Company, Allen Bloom, Thomas M Saunders, January 26, 1988: US04721612 (92 worldwide citation)

Methods and compositions are described for the preparation of lipid vesicles, the bilayers of which comprise a salt form of an organic acid derivative of a sterol such as the tris-salt form of a sterol hemisuccinate. The method is rapid, efficient, and does not require the use of organic solvents. T ...


10
Helen C Loughrey, Pieter R Cullis, Marcel B Bally, Lewis S Choi: Method for protein-liposome coupling. The Liposome Company, Kenneth B Rubin, March 21, 1995: US05399331 (86 worldwide citation)

This invention relates to a method for synthesizing a substantially pure reactive lipid including, for example, N-[4-(p-maleimidophenyl)-butyryl]phosphatidylethanolamine (MPB-PE) and related compositions. The compositions of the present invention are useful as coupling agents and may be incorporated ...